Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications

Godino, Andrea; Renard, Georgina M.

doi:10.1111/jne.12611

Cited by 14 publications

(9 citation statements)

References 149 publications

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“…9 Interestingly, acute AMPH administration decreases LS vasopressin (AVP) content in male rats but not in females. 10 AVP is a neuropeptide that has been related to the effects of drugs of abuse, 11 but its role in the addictive process is poorly understood. The AVP receptor type 1A (V 1A ) is abundant in the LS, 12,13 and LS is densely innervated by vasopressinergic afferents from the extended amygdala, 14 mainly from the bed nucleus of the stria terminalis.…”

Section: Introductionmentioning

confidence: 99%

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

et al. 2019

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The lateral septum (LS) is a limbic nucleus interconnected with several brain areas involved in the regulation of mood and reward. Vasopressin (AVP) is a neuropeptide that has been related to the effects of drugs of abuse, but its role in the addictive process is poorly understood. LS expresses a high density of AVP 1A receptors (V 1A). The aim of this work was to examine whether the modulation of LS AVP system affects the behavioral and neurochemical responses to amphetamine (AMPH) in male rats. Our results show that AMPH-induced conditioned place preference (CPP) produces a decrease in LS AVP content. Besides, we demonstrate that the microinjection of AVP in the LS impairs the expression of AMPH-induced CPP and that this effect is mediated by the activation of the V 1A receptor in the LS. AVP microinjection in the LS elicited a decrease in neuronal activity in the nucleus accumbens (NAc) in animals subjected to AMPH conditioning. Finally, AVP microinjection in the LS decreased dopamine (DA) release in the NAc. Overall, our data demonstrate that intra-LS AVP diminishes the expression of AMPH conditioning behavior while decreasing neuronal activity and DA release in the NAc. Presumably, the effects of AVP in the LS produce an inhibition of GABAergic projections to the VTA, increasing local inhibitory tone in this nucleus, which in turn reduces the activity of DA projections to NAc. Thus, these results contribute to the knowledge about the role of AVP in LS in regulating the reward circuit and addictive like behaviors.

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Section: Introductionmentioning

confidence: 99%

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

et al. 2019

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“…In adult female mandarin voles, PAE resulted in reductions in OT fibers within the PVN and SON as measured by OT immunohistochemistry (He et al, 2012). Studies investigating the effects of PAE on the AVP system have generally done so within the context of stress regulation and have shown long-lasting alterations to the AVP system (Godino and Renard, 2018). Additionally, previous work from our laboratory indicates that PAE alters sensitivity of central AVP pathways to testosterone in adult males (Lan et al, 2009, 2006).…”

Section: Introductionmentioning

confidence: 99%

Prenatal alcohol exposure disrupts male adolescent social behavior and oxytocin receptor binding in rodents

Holman

Ellis

Morgan

et al. 2018

Hormones and Behavior

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Social behavior deficits resulting from prenatal alcohol exposure (PAE) emerge early in life and become more pronounced across development. Maturational changes associated with adolescence, including pubertal onset, can have significant consequences for social behavior development, making adolescence a unique period of increased vulnerability to social behavior dysfunction. Unfortunately, little is known about the underlying neurobiology supporting PAE-related social behavior impairments, particularly in the context of adolescence, when the transition to a more complex social environment may exacerbate existing deficits in social behavior function. Here we perform a comprehensive evaluation of social behavior development in PAE animals during two different periods in adolescence using three separate but related tests of social behavior in increasingly complex social contexts: the social interaction test, the social recognition memory test (i.e. habituation-dishabituation test), and the social discrimination test. Additionally, we investigated the underlying neurobiology of the oxytocin (OT) and vasopressin (AVP) systems following PAE, given their well-documented role in mediating social behavior. Our results demonstrate that compared to controls, early adolescent PAE animals showed impairments on the social recognition memory test and increased OT receptor binding in limbic networks, while late adolescent PAE animals exhibited impairments on the social discrimination test and increased OTR binding in forebrain reward systems. Taken together, these data indicate that PAE impairs adolescent social behavior - especially with increasing complexity of the social context - and that impairments are associated with altered development of the OT but not the AVP system.

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“…In the periphery, AVP receptor stimulation could be responsible for symptoms usually reported in PRES such as hyponatremia, acute hypertension, and impaired renal function (5,61). The use of cocaine, amphetamine (62), and lysergic acid diethylamide (63) and co-administration of alcohol with disulfiram (5) are known situations to stimulate AVP neurons. Thus, these agents could be directly responsible for the pharmacological cascade described above.…”

Section: Avp Axis Hyperstimulationmentioning

confidence: 99%

“…In hepatic encephalopathy, in addition to dysregulation of cerebral blood flow and consequent cerebral vasodilation induced by hyperammonemia (32), ammonia reaching the astrocytes is detoxified in glutamine, and its overproduction promotes, through AVP stimulation, astrocytic swelling, resulting in brain edema (65). In contrast, acute alcohol intoxication (62) and licorice (66) inhibit AVP release, and lithium inhibits renal effects of AVP (5). In PRES associated with alcohol withdrawal (26)(27)(28), licorice (44), and lithium intoxication (33,34), the onset of neurological symptoms ranged from 2 to 9 days after intoxication; this chronology of events may suggest a rebound phenomenon on the AVP axis (5).…”

Section: Avp Axis Hyperstimulationmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome in Clinical Toxicology: A Systematic Review of Published Case Reports

et al. 2020

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Background: Posterior reversible encephalopathy syndrome (PRES) is a rare clinical and radiological entity characterized by a typical brain edema. Although several case reports have described PRES in a context of poisoning, to our knowledge, a comprehensive assessment has not been performed. The aim of this systematic review was to raise awareness on poisoning-specific PRES features and to encourage consistent and detailed reporting of substance abuse-and drug overdose-associated PRES. Methods: Medline/PubMed, Web of Science, and PsycINFO were screened through May 31, 2019, to systematically identify case reports and case series describing PRES associated with poisoning (i.e., alcohol, drugs, illicit drugs, natural toxins, chemical substances) in accidental context, intentional overdose, and substance abuse. The methodological quality of eligible case reports/series was assessed. Patients and exposure characteristics were recorded; relevant toxicological, radiological, and clinical data were extracted. Results: Forty-one case reports and one case series reporting 42 unique cases were included. The median time to PRES onset from the start of exposure was 3 days (IQR 2-10). Acute high blood pressure, visual disturbance, and seizure were reported in 70, 55, and 50% of patients, respectively. The initial clinical presentation was alertness disorders in 64% of patients. Nine patients (21%) required mechanical ventilation. One-third of patients had at least one risk factor for PRES such as chronic hypertension (17%) or acute/chronic kidney failure (24%). The main imaging pattern (67%) was the combination of classical parieto-occipital edema with another anatomical region (e.g., frontal, basal ganglia, posterior fossa involvement). Vasogenic edema was found in 86% of patients. Intracranial hemorrhage occurred in 14% of patients. Both brain infarction and reversible cerebral vasoconstriction syndrome were diagnosed in 5% of patients. Three patients (12%, 3/25) had non-reversible lesions on follow-up magnetic resonance Largeau et al. PRES in Clinical Toxicology imaging. The median time required to hospital discharge was 14 days (IQR 7-18). Mortality and neurological recurrence rate were null. Conclusions: Comorbidities such as chronic hypertension and kidney failure were less frequent than in patients with other PRES etiologies. Imaging analysis did not highlight a specific pattern for poisoning-induced PRES. Although less described, PRES in the context of poisoning, which shares most of the clinical and radiological characteristics of other etiologies, is not to be ignored.

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Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications

Cited by 14 publications

References 149 publications

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

Prenatal alcohol exposure disrupts male adolescent social behavior and oxytocin receptor binding in rodents

Posterior Reversible Encephalopathy Syndrome in Clinical Toxicology: A Systematic Review of Published Case Reports

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