Effects of Alcohol on Carbohydrate Metabolism in Man

Freinkel, Norbert; Arky, Ronald A.

doi:10.1097/00006842-196607000-00032

Cited by 27 publications

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Diphenylhydantoin and an Insulin-Secreting Islet Adenoma

Knopp

Sheinin²,

Freinkel³

1972

Arch Intern Med

View full text Add to dashboard Cite

The diagnosis of an insulin-secreting islet cell adenoma was obscured in a patient treated with diphenylhydantoin sodium. Comparison of insulin responses to glucagon, tolbutamide, and leucine before and after drug withdrawal indicated that the diphenylhydantoin was inhibiting "stimulated" insulin release from the tumor.Another clue to hyperinsulinism was the restraint of hepatic ketogenesis and urinary nitrogen excretion during fasting. Diphenylhydantoin, or an analogue, may deserve further trial as adjunctive therapy in the control of insulinoma-induced hypoglycemia.The hyperglycémie potential of diphenylhydantoin sodium was first recognized by Belton et al in 1965.1 Since then, hyperglycemic-hyperosmolar coma has been associated repeatedly with diphenylhydantoin intoxication.2'7 In one case, intoler¬ ance to orally given glucose was in¬ duced by conventional doses of di¬ phenylhydantoin.8 It is believed that diphenylhydantoin causes hyperglycemia by inhibiting insulin release from the pancreas.7-9·10·11 In this light, the effect of diphenylhydantoin ther¬ apy on insulin secretion from an islet cell tumor is potentially important and is the basis for this report. Patient SummaryHistory.-A 44-year-old auto mechanic had been suffering grand mal seizures from childhood onward. In 1950, he was first seen at Northwestern University Medical Clinics for seizures. These had oc¬ curred several times yearly, sometimes be¬ ginning in the left arm and face, but al¬ ways progressing to generalized, tonicclonic activity followed by brief periods of unconsciousness and two to three hours of postictal drowsiness. Seizures would com¬ monly occur during sleep or after alcohol intake, but also while awake and, on one occasion, while driving. A maternal uncle had seizures; there was no other family history of epilepsy or diabetes. Physical examination disclosed no neurological abnormality. Medications consisted of di-

show abstract

Diphenylhydantoin and an Insulin-Secreting Islet Adenoma

Knopp

Sheinin²,

Freinkel³

1972

Arch Intern Med

View full text Add to dashboard Cite

show abstract

Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequences in vivo and in vitro

et al. 1981

View full text Add to dashboard Cite

Acute ethanol administration results in increased hepatic NADH/NAD+ ratio and inhibition of galactose elimination, tricarboxylic acid cycle activity, and fatty acid oxidation. To determine how this redox change is affected by chronic alcohol consumption and to assess the resulting metabolic consequences, we studied baboons which were fed alcohol as 50% of their total calories. Redox changes were evaluated through measurement of galactose elimination in vivo and lactate/pyruvate ratios in liver slices in vitro. The metabolic consequences of these changes were assessed through measurement of CO2 production and fatty acid oxidation in liver slices and hepatic lipid accumulation. Chronic alcohol feeding resulted in attenuation of inhibition of galactose elimination, increase in the lactate/pyruvate ratio, and decrease in fatty acid oxidation which were caused by acute ethanol administration. These metabolic adaptations were associated with reduced accumulation of hepatic fat.

show abstract

Pathogenesis of Alcoholic Liver Disease: An Overview

Lieber

1977

Alcohol and the Liver

View full text Add to dashboard Cite

Effects of Alcohol on Carbohydrate Metabolism in Man

Cited by 27 publications

References 24 publications

Diphenylhydantoin and an Insulin-Secreting Islet Adenoma

Diphenylhydantoin and an Insulin-Secreting Islet Adenoma

Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequences in vivo and in vitro

Pathogenesis of Alcoholic Liver Disease: An Overview

Contact Info

Product

Resources

About