Effects of alcohol on disinhibition towards alcohol-related cues

Adams, Sally; Ataya, Alia F.; Attwood, Angela; Munafò, Marcus R.

doi:10.1016/j.drugalcdep.2012.06.025

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…In line with this interpretation, false alarm rates did not vary across the alcohol and placebo conditions. Similar to previous findings (Adams et al, 2013;Kreusch et al, 2013), subjects gave more go responses for alcohol cues both in Go and NoGo trials, suggesting that alcohol cues may be more associated with an approach or a go response. Moreover, hit rates for neutral cues were more sensitive to acute alcohol effects; subjects made more omissions for neutral cues after acute alcohol.…”

Section: Discussionsupporting

confidence: 88%

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Alcohol-Induced Changes in Conflict Monitoring and Error Detection as Predictors of Alcohol Use in Late Adolescence

Korucuoglu

Gladwin

Wiers

2014

Neuropsychopharmacol

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Adolescence is a vulnerable period for the development of substance use and related problems. Understanding how exposure to drugs influences the adolescent brain could reveal mechanisms underlying risk for addiction later in life. In the current study, 87 adolescents (16-20-year olds; the local legal drinking age was16, allowing the inclusion of younger subjects than usually possible) underwent EEG measurements during a Go/No-Go task with and without alcohol cues; after placebo and a low dose of alcohol (0.45 g/kg). Conflict monitoring and error detection processes were investigated with the N2 and the error-related negativity (ERN) ERP components. Participants were followed-up after 6 months to assess changes in alcohol use. The NoGo-N2 was larger for alcohol cues and acute alcohol decreased the amplitude of the NoGo-N2 for alcohol cues. ERN amplitude was blunted for alcohol cues. Acute alcohol decreased the amplitude of the ERN, specifically for control cues. Furthermore, the differences in ERN for alcohol cues between the placebo and alcohol conditions predicted alcohol use 6 months later: subjects who showed stronger blunting of the ERN after acute alcohol were more likely to return to more moderate drinking patterns. These results suggest that cues signalling reward opportunities might activate a go-response mode and larger N2 (detection of increased conflict) for these cues might be necessary for inhibition. The ERN results suggest a deficiency in the monitoring system for alcohol cues. Finally, a lack of alcohol-induced deterioration of error monitoring for cues with high salience might be a vulnerability factor for alcohol abuse in adolescents.

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Section: Discussionsupporting

confidence: 88%

“…This may be due to an increase in appetitive motivation towards drug cues and/or a decrease in regulatory cognitive control (Ridderinkhof et al, 2002;Duka and Townshend, 2004;Hernández and Vogel-Sprott, 2010;Adams et al, 2013). Acute alcohol effects may mimic long-term effects and could thus predict escalation (Wiers et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Alcohol-Induced Changes in Conflict Monitoring and Error Detection as Predictors of Alcohol Use in Late Adolescence

Korucuoglu

Gladwin

Wiers

2014

Neuropsychopharmacol

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“…Relations between SUPPS-P facets and various external criteria were generally similar to those found using the UPPS-P. Correlates between SUPPS-P facets and alcohol involvement (as assessed by the AUDIT) were similar in magnitude to one non-clinical study (Adams, Ataya, Attwood, & Munafo, 2012) but were smaller in magnitude compared to another study (Murphy & MacKillop, 2012). Sensation seeking correlated similarly with drug use compared to a work that utilized the full scale, but other facets from the abbreviated scale showed lower magnitude correlations (Zapolski, Cyders, & Smith, 2009).…”

Section: Discussionsupporting

confidence: 67%

Examination of a short English version of the UPPS-P Impulsive Behavior Scale

Cyders

Littlefield

Coffey

et al. 2014

Addictive Behaviors

567

416

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The current study examines a recently developed short version of the UPPS-P Impulsive Behavior Scale. Participants were 251 undergraduate students (59.3% male; mean age = 21.16 (SD = 4.18); 72% Caucasian). The short version generally replicated the internal consistency (0.74 – 0.88 across subscales) and inter-scale correlations of the full UPPS-P. Moreover, the estimated loss of shared variance was small (0% – 6.4% reductions across subscales) as compared to a 66% time-savings. Structural equation modeling replicated previously supported factor structures and relationships to external outcomes using the full UPPS-P. The short UPPS-P scale should be considered a valid and reliable alternative to the full UPPS-P.

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“…In support of chronic alcohol consumption effects on risky behaviour, persistent heavy alcohol use appears to be associated with changes in brain structures linked to behavioural control, such as frontal lobe functioning alternations and neurodegeneration (Crews & Boettiger, 2009). The latter (acute consumption) is largely assessed using alcohol administration procedures which often find that intoxicated individuals (opposed to control) demonstrate impaired behaviour inhibition (Adams, Ataya, Attwood, & Munafò, 2013;Weafer & Fillmore, 2012b). …”

Section: Disinhibitionmentioning

confidence: 99%