Effects of alcohol on lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation

Nishiwaki, Masato; Ishikawa, Takahiro; Ito, Tsuyoshi; Shige, Hideki; Tomiyasu, Koji; Nakajima, Kei; Kondo, Kazuo; Hashimoto, Hideyuki; Saitoh, Kazunori; Manabe, Mitsuhisa; Miyajima, Emiko; Nakamura, Haruo

doi:10.1016/0021-9150(94)90195-3

Cited by 103 publications

(70 citation statements)

References 46 publications

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“…The reduction of CETP and the increase of PLTP were confirmed by another study, which also observed an increase in the net PL transfer from apoB-containing lipoproteins to HDL in alcoholics (38). However, none of these enzymes seems to be changed in moderate alcohol consumers (39)(40)(41). In our study, the analysis of HDL 2a and HDL 3 composition shows an isolated dose-dependent increase of the PLs compared with apoA-I, whereas the ratio of FC to apoA-I remained unchanged, which argues for a role of PLTP in PL enrichment in these HDL subclasses.…”

Section: Discussionsupporting

confidence: 63%

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

Schäfer

Parlesak

Eckoldt

et al. 2007

Journal of Lipid Research

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The reduction of cardiovascular mortality associated with moderate alcohol consumption is chiefly thought to be mediated by an increase of high density lipoprotein cholesterol (HDL-CH). This study highlights additional qualitative changes of HDL that might augment this antiatherogenic effect. In 279 healthy men, alcohol and nutrient consumption were evaluated. Groups 1 (n 5 62), 2 (n 5 172), and 3 (n 5 45) comprised subjects with alcohol consumption of 0-5.0, 5.1-30.0, and 30.1-75 g/day, respectively. Lipid analysis was performed in nonfractionated and fractionated plasma, including subfractions HDL 2a , HDL 2b , and HDL 3 . No difference in LDL-cholesterol was observed. Compared with group 1, groups 2 and 3 exhibited significant increases of HDL-CH (group 1, 44 6 10 mg/dl; group 2, 51 6 11 mg/dl; group 3, 55 6 11 mg/dl; mean 6 SD, P , 0.0005), accompanied by enhanced lipidation of HDL (increase of the HDL 2 -CH/HDL 3 -CH ratio). Moreover, phospholipid enrichment of HDL occurred in alcohol consumers, whereas the ratios between other HDL components remained constant. Multivariate analysis revealed alcohol to have the foremost statistical influence on changes of the HDL fraction, followed by body mass index and physical activity level. The increased lipidation of HDL found in alcohol consumers might augment the antiatherogenic effect of HDL-CH increase. In addition, the phospholipid enrichment of HDL might reduce the inflammatory response of

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Section: Discussionsupporting

confidence: 63%

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

Schäfer

Parlesak

Eckoldt

et al. 2007

Journal of Lipid Research

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“…Alcohol-induced increase in activity of lipoprotein lipase which transfers of cholesterol and phospholipids from triglyceride-rich lipoproteins to HDL during the lipolysis may be a possible explanation for HDL-C increase due to alcohol consumption [11,12].…”

Section: Resultsmentioning

confidence: 99%

Effects of Alcohol Consumption on HDL Metabolism in Asian Populations

Yanai

2014

J Endocrinol Metab

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Low serum high-density lipoprotein-cholesterol (HDL-C) is an independent coronary risk factor, because HDL acts to mediate the uptake of peripheral cholesterol and return it to the liver. Therefore, raising HDL-C may be one of the goals in the management of atherogenic dyslipidemia for cardiovascular disease risk reduction. Although lifestyle modification such as diet and exercise may be important to increase HDL-C, effects of dietary factors on HDL-C remained largely unknown. Interracial differences on HDL metabolism may exist. Here we reviewed published articles about effect of alcohol consumption on HDL metabolism in Asian populations, regarding systematic review and meta-analysis and also clinical studies performed in Asian populations as important articles in this review.

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“…The means and their confidence intervals presented for TG correspond to the antilog of the log-transformed values. Because of the low numbers of individuals homozygous for the rare allele, they were pooled with heterozygotes and subsequently by guest, on April 29, 2019 www.jlr.org…”

Section: Statistical Analysesmentioning

confidence: 99%

The lipoprotein lipase S447X polymorphism and plasma lipids

Lee

Tan

Chia

et al. 2004

Journal of Lipid Research

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We studied 4,058 subjects from a representative sample of the Singapore population 1 ) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and 2 ) to explore any interactions with apolipoprotein E ( APOE ) genotype, exercise, obesity, cigarette smoking, and alcohol intake. Information on obesity, lifestyle factors (including smoking, alcohol consumption, and exercise frequency), glucose tolerance, and fasting lipids was obtained. Male and female carriers of the X447 allele had lower serum triglyceride concentrations and higher HDL cholesterol (HDL-C) concentrations. The association between the X447 allele and serum HDL-C concentration was modulated by APOE genotype in males and cigarette smoking and alcohol intake in females. The effect of the X447 allele was greatest in men who carried the E4 allele and women who smoked or consumed alcohol. The X447 allele at the LPL locus is common and associated with a less atherogenic lipid profile in Asian populations. Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest. -Lee, J., C.

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Effects of alcohol on lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation

Cited by 103 publications

References 46 publications

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers

Effects of Alcohol Consumption on HDL Metabolism in Asian Populations

The lipoprotein lipase S447X polymorphism and plasma lipids

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