Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock

Ebata, Toshiaki; Hayasaka, Hiroshi

doi:10.1007/bf02468720

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…However, a slight, insignificant increase in Cort level was observed after swimming in both groups, which may be considered as a factor of stress related to swimming. After Dex treatment, Adr level drops, which may be related to Dex’s inhibitory action on releasing this hormone [ 35 ]. No changes in Adr level were observed after exercise in both groups.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

Flis

Bialobrodzka²,

Rodziewicz-Flis

et al. 2022

IJMS

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This study investigates the effect of Dexamethasone (Dex) treatment on blood and skeletal muscle metabolites level and skeletal muscle activity of enzymes related to energy metabolism after long-duration swimming. To evaluate whether Dex treatment, swimming, and combining these factors act on analyzed data, rats were randomly divided into four groups: saline treatment non-exercise and exercise and Dex treatment non-exercised and exercised. Animals in both exercised groups underwent long-lasting swimming. The concentration of lipids metabolites, glucose, and lactate were measured in skeletal muscles and blood according to standard colorimetric and fluorimetric methods. Also, activities of enzymes related to aerobic and anaerobic metabolism were measured in skeletal muscles. The results indicated that Dex treatment induced body mass loss and increased lipid metabolites in the rats’ blood but did not alter these changes in skeletal muscles. Interestingly, prolonged swimming applied after 9 days of Dex treatment significantly intensified changes induced by Dex; however, there was no difference in skeletal muscle enzymatic activities. This study shows for the first time the cumulative effect of exercise and Dex on selected elements of lipid metabolism, which seems to be essential for the patient’s health due to the common use of glucocorticoids like Dex.

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Section: Discussionmentioning

confidence: 99%

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

Flis

Bialobrodzka²,

Rodziewicz-Flis

et al. 2022

IJMS

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“…The glucocorticoid dexamethasone (DXM) is a corticosteroid that can act as an anti-inflammatory, anti-toxic, anti-allergic and anti-rheumatic drug [20][21][22][23]. It is widely used in clinical practice and is easily absorbed through the digestive tract.…”

Section: Dexamethasonementioning

confidence: 99%

Emerging medical therapies in crush syndrome – progress report from basic sciences and potential future avenues

Wang

et al. 2020

Renal Failure

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Crush injury is a disease that is commonly found in victims of earthquakes, debris flows, mine disasters, explosions, terrorist attacks, local wars, and other accidents. The complications that arise due to the crush injury inflicted on victims give rise to crush syndrome (CS). If not treated in time, the mortality rate of CS is very high. The most important measure that can be taken to reduce mortality in such situations is to immediately start treatment. However, the traditional treatment methods such as fluid resuscitation, diuresis, and hemodialysis are not feasible enough to be carried out at the disaster scene. So there is a need for developing new treatments that are efficient and convenient. Because it is difficult to diagnose in the disaster area and reach the treatment equipment and treat on time. It has become a new research needs to be directed into identifying new medical treatment targets and methods using the etiology and pathophysiological mechanisms of CS. In recent years, a large number of new anti-oxidant and anti-inflammatory drug therapies have been shown to be highly efficacious in CS rat/mouse models. Some of them are expected to become specific drugs for the emergency treatment of a large number of patients who may develop CS in the aftermath of earthquakes, wars, and other disasters in the future. Hence, we have reviewed the latest research on the medical therapy of CS as a source for anyone wishing to pursue research in this direction.

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“…Reduces the levels of plasma histamine, plasma serotonin, blood bradykinin, and plasma catecholamine concentration ( 105 )…”

Section: Immunomodulation In Sepsismentioning

confidence: 99%

“…In small animals, sepsis is associated with downregulation of the MR in endothelial cells ( 92 , 104 ), which is restored by supplementation by exogenous MR ( 104 ). In endotoxin shock, aldosterone reduces plasma levels of histamine, serotonin, bradykinin, and catecholamine ( 105 ). MR agonists reduce mortality in endotoxin-challenged small animals ( 107 – 109 ).…”

Section: Immunomodulation In Sepsismentioning

confidence: 99%

Immune Effects of Corticosteroids in Sepsis

et al. 2018

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Sepsis, a life-threatening organ dysfunction, results from a dysregulated host response to invading pathogens that may be characterized by overwhelming systemic inflammation or some sort of immune paralysis. Sepsis remains a major cause of morbidity and mortality. Treatment is nonspecific and relies on source control and organ support. Septic shock, the most severe form of sepsis is associated with the highest rate of mortality. Two large multicentre trials, undertaken 15 years apart, found that the combination of hydrocortisone and fludrocortisone significantly reduces mortality in septic shock. The corticosteroids family is composed of several molecules that are usually characterized according to their glucocorticoid and mineralocorticoid power, relative to hydrocortisone. While the immune effects of glucocorticoids whether mediated or not by the intracellular glucocorticoid receptor have been investigated for several decades, it is only very recently that potential immune effects of mineralocorticoids via non-renal mineralocorticoid receptors have gained popularity. We reviewed the respective role of glucocorticoids and mineralocorticoids in counteracting sepsis-associated dysregulated immune systems.

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Effects of aldosterone and dexamethasone on blood chemical mediators in endotoxin shock

Cited by 8 publications

References 11 publications

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

Emerging medical therapies in crush syndrome – progress report from basic sciences and potential future avenues

Immune Effects of Corticosteroids in Sepsis

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