Effects of alendronate and interferon-γ on bone cancer cells <i>in vitro</i>

Barone, Andrew W.; Fernandes, Gabriela; Dziak, Rosemary

doi:10.1080/23312025.2018.1427306

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Bisphosphonates have been utilized as therapeutic agents for the treatment of osteoporosis, Paget's disease, bone pain related to metastatic disease, hypercalcemia of malignancy, in diagnostic nuclear medicine, and targeted radiotherapy [134]. Therefore, the need for anti-osteoporotic agents that can be used for a prolonged duration with significant safety and efficacy is very important.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Bisphosphonate-Based Conjugates and Derivatives as Potential Therapeutic Agents in Osteoporosis, Bone Cancer and Metastatic Bone Cancer

Mbese

Aderibigbe

2021

IJMS

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Metastatic bone cancer occurs in every type of cancer but is prevalent in lung, breast, and prostate cancers. These metastases can cause extensive morbidity, including a range of skeletal-related events, often painful and linked with substantial hospital resource usage. The treatment used is a combination of chemotherapy and surgery. However, anticancer drugs are still limited due to severe side effects, drug resistance, poor blood supply, and non-specific drug uptake, necessitating high toxic doses. Bisphosphonates are the main class of drugs utilized to inhibit metastatic bone cancer. It is also used for the treatment of osteoporosis and other bone diseases. However, bisphosphonate also suffers from serious side effects. Thus, there is a serious need to develop bisphosphonate conjugates with promising therapeutic outcomes for treating metastatic bone cancer and osteoporosis. This review article focuses on the biological outcomes of designed bisphosphonate-based conjugates for the treatment of metastatic bone cancer and osteoporosis.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%