Effects of alkaline buffers on cytoplasmic pH in lymphocytes

Impact of various buffers and weak bases on lysosomal and intracellular pH: Implications for infectivity of SARS‐CoV‐2

“…Although extracellular pH can be corrected with administration of sodium bicarbonate, the effect of sodium bicarbonate on lysosomal pH is unclear. Carbicarb has been used experimentally to correct both extracellular and intracellular pH, however this buffer is not yet approved for clinical use 9 . THAM corrects extracellular pH, and in some studies also affects intracellular pH, however, similar to sodium bicarbonate, its effect on lysosomal pH is unclear 10 .…”

“…Carbicarb has been used experimentally to correct both extracellular and intracellular pH, however this buffer is not yet approved for clinical use. 9 THAM corrects extracellular pH, and in some studies also affects intracellular pH, however, similar to sodium bicarbonate, its effect on lysosomal pH is unclear. 10 Determining whether each of these buffers can alkalinize lysosomes is necessary to determine their potential utility in treating acid‐base disorders occurring in the context of various viral infections.…”