Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c)

Chaves, Juliana Ramos; Souza, Carolina Rosal Teixeira de; Modesto, Antônio André Conde; Moreira, Fabiano Cordeiro; Teixeira, Eliel Barbosa; Sarraf, Jonathan Souza; Allen, Thaís Suellen Ramos; Araújo, Taíssa Maíra Thomaz; Khayat, André Salim

doi:10.21203/rs.3.rs-19940/v1

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…In 2020, a recent study made by Chavez et al highlighted the effects of crenotherapy with alkaline water (pH=8.0-10.0) administered for five months for gastritis symptom relief. The results showed that besides the beneficial effect of crenotherapy with alkaline water on gastritis symptoms, an improvement in the RNA expression was present, the alkaline water intake significantly increasing the expression of various genes related to the digestion process (34).…”

Section: Evidence-based Literature Data Focused On the Benefit Of Crenotherapy For Gi (Gastrointestinal) Tract Pathologiesmentioning

confidence: 99%

Benefits of crenotherapy in digestive tract pathology (Review)

Dumitrescu

Iliescu²,

Mazilu³

et al. 2021

Exp Ther Med

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Balneotherapy, a branch of physical and rehabilitation medicine using the natural factors of balneal resorts for therapeutical purposes to modulate the symptoms of numerous diseases, represents a non-pharmaceutical therapeutic alternative, easily accepted by patients and used both preventively and curatively. Crenotherapy, a branch of balneotherapy, is the method in which mineral waters are used as a therapeutic internal cure by ingestion. This procedure is performed in spa resorts (where these natural resources exist), and the ingestion of mineral water takes place at the source (spring), in the quantities recommended by the medical rehabilitation physician, according to specific regimens for the condition to be treated. Depending on their physical and chemical composition, the therapeutic mineral waters fall into several categories, having clear indications for certain pathologies. Hypotonic, isotonic, or slightly hypertonic mineral waters are recommended in diseases of the digestive tract and hepatobiliary conditions. Over time, studies have been conducted to determine the effect of these types of treatments, highlighting the complex influence of crenotherapy on the gastrointestinal tract, with favorable results, therefore the use of mineral water intake in various pathologies being recommended. The current review focuses on the existing literature data and refers to the main progress made in understanding the benefit, indications, and crenotherapy procedures in the management of gastrointestinal disorders. Contents1. Introduction 2. Pathogenic background for crenotherapy usage 3. Evidence-based literature data focused on the benefit of crenotherapy for GI (gastrointestinal) tract pathologies 4. Conclusions

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Section: Evidence-based Literature Data Focused On the Benefit Of Crenotherapy For Gi (Gastrointestinal) Tract Pathologiesmentioning

confidence: 99%

Benefits of crenotherapy in digestive tract pathology (Review)

Dumitrescu

Iliescu²,

Mazilu³

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

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Differential Expression of Tissular miRNA-155 in Pediatric Gastritis

Oana

Bănescu

Lelia

et al. 2022

JCM

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Background: MicroRNA molecules, among them the intensely studied miRNA-155 (miR-155), are regarded as potential biomarkers of chronic gastric inflammation and premalignant lesion progression. However, literature data are scarce in terms of pediatric studies and in the evaluation of the predictive role of miRNA in early gastric inflammation. This study aims to assess the differential expression of miR-155 in relation to pediatric gastritis. Methods: The present research was conducted on 192 patients with chronic dyspeptic symptoms who underwent upper digestive endoscopy. Bioptic samples were harvested for histopathological analysis and tissue miR-155 depiction. MiR-155 expression analysis was carried out through quantitative real-time polymerase chain reaction (qRT-PCR). The study population was divided into two groups: controls (93 patients) and study group (99 patients) with inflammatory modifications. Results: MiR-155 expression was augmented in patients with gastritis but did not differ significantly from controls (p = 0.16). An increase in miR-155 expression was noted in relation to chronic gastritis, H. pylori infection, or increase in gastritis severity, but these variations were not important (p = 0.30, p = 0.44, and p = 0.45, respectively). Conclusions: According to our study, pediatric gastritis increases, but does not greatly influence, miR-155 expression. Dynamic evaluation of miR-155 might enlighten its prognostic role in pediatric gastritis.

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Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c)

Cited by 2 publications

References 35 publications

Benefits of crenotherapy in digestive tract pathology (Review)

Benefits of crenotherapy in digestive tract pathology (Review)

Differential Expression of Tissular miRNA-155 in Pediatric Gastritis

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