2004
DOI: 10.1016/j.aquatox.2003.12.007
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Effects of alkylphenols on CYP1A and CYP3A expression in first spawning Atlantic cod (Gadus morhua)

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Cited by 85 publications
(34 citation statements)
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“…In the freshwater mussel Dreissena polymorpha, significant inhibition of EROD activity was observed after laboratory exposure to DDT (Binelli et al 2006). Similar results are provided by more numerous studies on fish, where exposure to nonylphenol (Vaccaro et al 2005), alkylphenols (Hasselberg et al 2004), organotin compounds (Fent et al 1998) and heavy metals (Oliveira et al 2004) caused reduced EROD activity. In the present study, the lowest EROD activity was observed in crabs from Marghera, in which the lowest AChE activity was also found.…”
Section: Discussionsupporting
confidence: 82%
“…In the freshwater mussel Dreissena polymorpha, significant inhibition of EROD activity was observed after laboratory exposure to DDT (Binelli et al 2006). Similar results are provided by more numerous studies on fish, where exposure to nonylphenol (Vaccaro et al 2005), alkylphenols (Hasselberg et al 2004), organotin compounds (Fent et al 1998) and heavy metals (Oliveira et al 2004) caused reduced EROD activity. In the present study, the lowest EROD activity was observed in crabs from Marghera, in which the lowest AChE activity was also found.…”
Section: Discussionsupporting
confidence: 82%
“…It must also be considered that CYP1A catalytic activity varies between different xenobiotics and studies: variables such as species, sex, reproductive stage, compound, route of exposure, time of exposure, mixed exposure and/or dose may influence the observed effects. [59] A research study developed with Atlantic eel (Anguilla anguilla) showed a significant decrease in hepatic EROD activity after in vivo exposure to low doses (0.5 mg/L) of TNT (2,4,6-trinitrotoluene), but curiously no further decrease was observed when higher doses of this xenobiotic were assayed. [60] A similar decrease in EROD activity has been already reported in TNT-exposed rainbow trout (Onchorynchus mykiss), allowing us to hypothesize a potential role of TNT as a competitive inhibitor on EROD enzyme activity.…”
Section: Correlationsmentioning
confidence: 99%
“…Similar to mammals, some drugs and endogenous compounds can induce CYP3A gene expression in reptiles, amphibians, and fish. Chemically-induced upregulation of CYP3A expression has been demonstrated in microsomes from alligator liver by phenobarbital and 3-methylcholanthrene [192], in microsomes from a toad epithelial cell line by dexamethasone and corticosterone [193], in Atlantic cod by alkylphenols [194], in rainbow trout and killifish by ketoconazole [195], in adult zebrafish liver by pregnenolone 16α-carbonitrile (but not clotrimazole or nifedipine) [185], and in larval zebrafish foregut by rifampin and dexamethasone [196]. The molecular mechanism of CYP3A induction in the species mentioned above has not been determined.…”
Section: Nr1i Subfamily Members In Non-mammalian Speciesmentioning
confidence: 99%