Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

Kırmaz, Cengiz; Kirgiz, Ozlem Ozenturk; Bayrak, Papatya; Yılmaz, Özge; Vatansever, Seda; Özbilgin, Kemal; Onur, Ece; Çelik, Onur; Söğüt, Ayhan; Ay, Güngör; Yüksel, Hasan

doi:10.1684/ecn.2011.0277

Cited by 24 publications

(21 citation statements)

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“…It is thus likely that the changes in serum cytokines and chemokines are immunological paraphenomena of AIT that do not directly correlate with clinical outcome. Local rather than serum levels of cytokines may be more indicative of immunological and clinical effects of AIT, but few studies of local cytokines have been performed . For example, a cross‐sectional study demonstrated lower concentrations of Th2 cytokines (IL‐4, 5, 9 and 13) and chemokines (eotaxin) in local nasal fluid at 2–8 h after nasal allergen provocation following successful AIT compared to untreated controls .…”

Section: Resultsmentioning

confidence: 99%

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

Shamji

Kappen

Akdiş

et al. 2017

Allergy

305

367

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Background: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex interaction between patient, allergy triggers, symptomatology and vaccines used for AIT, some patients do not respond optimally to the treatment. Furthermore, there are no validated or generally accepted candidate biomarkers that are predictive of the clinical response to AIT. Clinical management of patients receiving AIT and efficacy in randomised controlled trials for drug development could be enhanced by predictive biomarkers. Method: The EAACI taskforce reviewed all candidate biomarkers used in clinical trials of AR patients with/without asthma in a literature review. Biomarkers were grouped into seven domains: (i) IgE (total IgE, specific IgE and sIgE/Total IgE ratio), (ii) IgG-subclasses (sIgG1, sIgG4 including SIgE/IgG4 ratio), (iii) Serum inhibitory activity for IgE (IgE-FAB and IgE-BF), (iv) Basophil activation, (v) Cytokines and Chemokines, (vi) Cellular markers (T regulatory cells, B regulatory cells and dendritic cells) and (vii) In vivo biomarkers (including provocation tests?). Results: All biomarkers were reviewed in the light of their potential advantages as well as their respective drawbacks. Unmet needs and specific recommendations on all seven domains were addressed.

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Section: Resultsmentioning

confidence: 99%

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

Shamji

Kappen

Akdiş

et al. 2017

Allergy

305

367

View full text Add to dashboard Cite

show abstract

“…Th1 cells result from an IL-12 and IFN-γ driven polarization of naïve CD4+ T cells (Th0) towards a Th1 phenotype. Lower Th1 numbers and thus, lower Th1-derived IFN-γ levels were found in nasal lavage fluids of AR patients compared to controls [ 12 ]. A higher IL-4 and lower IFN-γ production in cultured blood Th cells from pollen-sensitized seasonal AR patients is found compared to controls implying a Th2 skewing in allergic disease [ 13 ].…”

Section: Blood Cells In Armentioning

confidence: 99%

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Jordakieva

Jensen‐Jarolim²

2018

World Allergy Organization Journal

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Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal symptoms and other allergic conditions, such as conjunctivitis and asthma, however, support a more systemic disease impact. In addition to acute elevation of soluble inflammatory mediators in periphery blood, a growing number of studies have reported changes in circulating blood cells after specific nasal allergen challenge or environmental allergen exposure. These findings imply an involvement of specific blood leukocyte subsets, thrombocytes and recently, erythrocytes. This review summarizes the circulating blood cell dynamics associated with allergen exposure in AR subjects reported so far. Additionally, the impact of therapy, particularly allergen-specific immunotherapy (AIT), the only currently available causal treatment reducing AR-related symptoms, is further considered in this context.

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“…Enhanced Th2 cytokine responses and lower levels of IFN-γ from Th1 cells have been reported in NAL fluid from patients with AR [ 37 – 41 ]. However, our study showed that the levels of nasal Th-related cytokines (Th1, Th2, and Th17) did not differ between patients with AR and NAR regardless of age group.…”

Section: Discussionmentioning

confidence: 99%

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

Lee

Shim

et al. 2016

PLoS ONE

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BackgroundAllergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR.ObjectiveTo compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups.MethodsFifty-one patients with chronic rhinitis were enrolled and grouped into children (N = 27, mean age 7.2 years) and adults (N = 24, mean age 29.9 years). Diagnosis of AR was based on symptoms, skin prick tests and serum specific IgEs. Nasal lavage (NAL) fluids were collected from all subjects and used to measure the levels of total IgE, specific IgEs to house dust mites (Dp and Df), and cytokines (TNF-α, IL-4, IL-10, IL-17A and IFN-γ). Flow cytometry was used to measure inflammatory cell types in NAL fluids.ResultsAR had significantly increased local levels of total IgE and specific IgEs to Dp and Df compared with NAR in both age groups (P < 0.05). Nasal eosinophils % (P = 0.01) was significantly increased only in children with AR. Local-systemic correlations of total IgE (r = 0.662, P = 0.000) and eosinophil % (r = 0.461, P = 0.015) between the peripheral blood and NAL fluids were found only in children. Moreover, children had correlations between total IgE and eosinophil % in the peripheral blood (r = 0.629, P = 0.001) and in NAL fluids (r = 0.373, P = 0.061).ConclusionElevated local IgE is a common feature of AR in children and adults. Local measures in NAR showed naïve state of immune response which disagree with the hypothesis of local allergic rhinitis. Children showed intense local inflammation and close local-systemic interactions compared to adults supporting pediatric AR as a distinct feature.

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Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

Cited by 24 publications

References 0 publications

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

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