Effects of Allium sativum Bulb Extract,Diminazene Aceturate and Their Combination onParasitaemia, and Biochemical Indices in RatsExperimentally Infected with TrypanosomaBrucei Brucei

Abstract

Thirty five clinically healthy albino rats of both sexes weighing between 100 -120grams were used to study the effects of Allium sativum bulb extract in combination with diminazene aceturate on parsitemia and biochemical indices in trypanosome brucei brucei infection. The rats were divided in to seven groups (A-G) of five rats each. All the infected rats developed Parasitemia five days post infection. Weakness, increase respiratory rate, rough hair coat Biochemical changes at interval and possible deaths were the major parameters which were carefully observed. All the treatment commenced at the onset of parasitemia by day five post infection. Sub therapeutic dose of Allium sativum at 20mg/kg/bw in combination with 1.7mg/kg/bw of diminazene aceturate (Group C),diminazene aceturate at single standard dose of 3.5mg/kg/bw (Group B) caused a significant reduction (P<0.05) in parasitemia. The liver function enzymes ALT AST level in rats infected and not treated showed significant increase liver function enzymes (Group A) while those treated with standard and sub therapeutic dose (Group BCD) respectively. Had their liver function enzymes towards normal, compare with control (Group G).Its trypanocidal activity was assessed through daily examination of blood parasite, sub therapeutic doses of Allium sativum bulb extracts and its combination appear to be more effective in reducing severity of trypanosome brucei brucei infection and provide alternative in reducing the toxicity of existing trypanocide.

Antioxidant potential and antibacterial activities of Allium cepa (onion) and Allium sativum (garlic) against the multidrug resistance bacteria

“…Garlic contains minerals like germanium, calcium, copper, iron, potassium, magnesium, selenium, zinc, vitamins A, B 1, C, fiber, and water (Gebreselema and Mebrahtu 2013). Research has proved that garlic has medicinal effects on a wide range of pathologic conditions of ringworm, Candida, and vaginitis due to its fungicidal, tonic, antiseptic, and parasiticidal activities, which are of high benefit in the management of the illhealth condition (Peni et al 2012).…”