Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis

Shirgholami, Zahra; Borji, Hassan; Mohebalian, Hadi; Heidarpour, Mohammad

doi:10.1016/j.exppara.2020.108042

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Conversely, patients with cysts active or transitional state displayed an exclusive expression of Th2 cytokines, the authors referred their observation to dependence of immune response on clinical manifestations and the therapeutic intervention’s efficacy (Riganò et al 2004). Shirgholami et al (2021) also reported a significant increase in levels of IFN-γ concentrations when compared to the control; however, their ABZ group showed the lowest concentration of IFN- γ (Shirgholami et al 2021). We attribute the difference reported in ABZ-treated mice to the duration of infection, administered dose of the drug, and drug regimen.…”

Section: Discussionmentioning

confidence: 98%

An in vivo appraisal of Punica granatum peel extract’s ultrastructural effect on cystic echinococcosis in mice

Nassef,

Shendi,

Saad

et al. 2024

J. Helminthol.

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In the past decade, interest has significantly increased regarding the medicinal and nutritional benefits of pomegranate (Punica granatum) peel. This study examined the effects of using pomegranate peel extract (PGE) alone and in combination with albendazole (ABZ) on ultrastructural and immunological changes in cystic echinococcosis in laboratory-infected mice. Results revealed that the smallest hydatid cyst size and weight (0.48 ± 0.47mm, 0.17 ± 0.18 gm) with the highest drug efficacy (56.2%) was detected in the PGE + ABZ group, which also exhibited marked histopathological improvement. Ultrastructural changes recorded by transmission electron microscopy including fragmentation of the nucleus, glycogen depletion, and multiple lysosomes in vacuolated cytoplasm were more often observed in PGE + ABZ group. IFN-γ levels were significantly increased in the group treated with ABZ, with a notable reduction following PGE treatment, whether administered alone or in combination with ABZ. Thus, PGE enhanced the therapeutic efficiency of ABZ, with improvement in histopathological and ultrastructural changes.

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Section: Discussionmentioning

confidence: 98%

An in vivo appraisal of Punica granatum peel extract’s ultrastructural effect on cystic echinococcosis in mice

Nassef,

Shendi,

Saad

et al. 2024

J. Helminthol.

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“…Similarly, in our work, treatments with A. asarense and A. jesdianum bulbs extract suppressed IFN-γ and IL-17 production, respectively, as inflammatory cytokines. Shirgholami et al [32] reported substantial increases in the IFN-γ levels in serum of infected BALB/c mice with cystic echinococcosis after administrating 20 mg/ kg and 80 mg/kg methanolic extract of A. sativum. Several factors may influence the production of cytokines in the treated lymphocytes with extracts of Allium species.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Impacts of Bulbs Extracts From Five Allium Species on IFN-γ, IL-4, and IL-17 Cytokines

et al. 2022

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Background: Nowadays, the impacts of medicinal plants on immune-related diseases are one of the main pharmacological approaches. Thus, here, the modulatory potential of some Allium species on T helper cell cytokines were investigated. Materials and Methods: The different concentrations of aqueous extract of the aged bulbs of five Allium species were prepared. Lymphocytes were then isolated and cultured in the presence of the bulb extracts. The amounts of IFN-γ, IL-4 and IL-17 were assessed using ELISA. Results: The results demonstrated that A. sativum bulbs extract increased IFN-γ production at all concentrations, especially at 0.0001 and 0.01 mg/mL. After treatment with all doses of A. asarense bulbs extract, IFN-γ production by lymphocytes was dropped, and this effect was remarkable at the lowest concentrations (0.0001, 0.001 and 0.005 mg/mL). The bulbs extract of A. asarense enhanced IL-4 production by the treated cells, whereas the bulbs extracts of A. sativum, A. jesdianum, and A. lenkoranicum had inhibitory effects on the production of IL-4. Treatment with the bulbs extracts of A. sativum and A. asarense caused increases in the secretion of IL-17 by the lymphocytes to some extent; however, the cytokine production decreased somewhat after incubation with A. jesdianum bulbs extracts. IFN-γ/ IL-4 ratio was raised after treatment of lymphocytes with A. stipitatum and A. sativum bulbs extracts, while incubation with A. asarense bulbs extracts decreased it. Conclusion: Since the bulbs extracts of the studied Allium species demonstrated immunomodulatory features, with further research, they would be considered as useful candidate for clinical purposes.

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“…The results of this study were different from those by Swargiary et al (2021) who reported Andrographis paniculata, Alstonia scholaris, Ananas comosus, and Azadirachta indica to be the dominant anthelmintic plants. Despite having a low RFC value of 0.013 during the investigation, Flemingia vestita (Das et al 2009;Toner et al 2008), Zingiber offficinale (Ghafar et al 2021;Kiambom et al 2021;Toulah et al 2019), Azadirachta indica (Ibekwe 2019;Salma et al 2021;Yamson et al 2019), and Allium sativum (Azra et al 2019;Luce 2019;Shirgholami et al 2021) plants' tubers have been widely explored as a source of anthelmintic chemicals against helminths and their important proteins (enzymes). Genistein, the active component derived from Flemingia vestita tubers, has been extensively studied for its efficacy against several forms of helminths (Moharm et al 2020…”

Section: Species Relative Frequency Of Citation (Rfc)mentioning

confidence: 99%

Tuberous plants with active compounds against helminths in livestock: A systematic review

Mpofu

Mugumbate²,

Gomo³

et al. 2022

Ethnobot. Res. App.

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Background: The rise in drug resistance to helminthiases is posing a serious challenge to conventional techniques of controlling parasitic illnesses in livestock. Using less conventional approaches such as plant extracts can improve the situation. This research aims to explore the emerging role of tuberous plants in developing anthelmintics.Methods: From October 2020 to July 2022, a comprehensive literature search was conducted using the search engines Google Scholar, NISCAIR Online Periodicals Repository, NCBI, Taylor and Francis Online, Wiley Online Libraries, Science Direct, ResearchGate, and Springer Link. The evaluation included only tuberous plants with anthelmintic properties. Qualitative-quantitative analysis techniques were used to analyse the data collected.Results: Forty-eight ethnobotanical investigations recorded plants with tuber portions that were utilized to combat helminths. There were 43 plants identified, divided into 24 families. Seven plants were found to be the most culturally important in the management of helminths. The common phytochemical classes were phytosterols, tannins, alkaloids, saponins, essential oils, flavonoids, and terpenoids. Twenty-six of these tuberous plants have been tested for their anthelmintic effect against trematodes, cestodes, nematodes, protozoa, coccidian, and eoacanthacephala. Thirty-two plants have been reported to exhibit some toxicity effects. Twelve tuberous plants have been indicated to be endangered.Conclusions: Dioscorea deltoidea, Dioscorea bulbifera, Dioscorea alata, Gloriosa superba, Curcuma longa, Dioscorea pentaphylla, and Cyperus rotundus were the most culturally important plants for controlling helminths.These plants are mostly found in India and Nepal. The review gave more insights into the therapeutic safety of the popular folklore drugs and provided grounds for an assessment of possible measures to be introduced before conducting clinical studies. The article provides public and Government recognition of endangered plants species and spurs conservation efforts toward saving both plants and folk medicinal knowledge. There is a need to investigate other tuberous plants to identify unique compounds that are active against helminths to develop more robust anthelmintic drugs and reduce anthelmintic resistance levels.

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Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis

Cited by 10 publications

References 23 publications

An in vivo appraisal of Punica granatum peel extract’s ultrastructural effect on cystic echinococcosis in mice

An in vivo appraisal of Punica granatum peel extract’s ultrastructural effect on cystic echinococcosis in mice

Immunomodulatory Impacts of Bulbs Extracts From Five Allium Species on IFN-γ, IL-4, and IL-17 Cytokines

Tuberous plants with active compounds against helminths in livestock: A systematic review

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