Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro

Ahluwalia, Bani; Magnusson, Maria K.; Isaksson, Stefan; Larsson, Fredrik; Öhman, Lena

doi:10.1016/j.jep.2016.01.003

Cited by 23 publications

(22 citation statements)

References 27 publications

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“…), which play an important role in genesis/maturation process of inflammatory cells; furthermore, a more recent study has directly reported the suppression effect of Aloe vera on T‐cell proliferation as well as cytokine secretion in PBMC cultures such as IL‐2, INF‐γ (Ahluwalia et al . ). Thus, it is hard to preclude the possibility that AWFP may induce the reduction in WBC and lymphocytes in peripheral blood.…”

Section: Discussionmentioning

confidence: 97%

Treatment‐related changes after short‐term exposure of SD rats to Aloe vera whole‐leaf freeze‐dried powder

Chen

Wang

2017

Int J Experimental Path

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Aloe vera is a widely used natural herb from which many sorts of commercial products have been derived using different preparation technologies. Aloe whole-leaf powder is one of the most popular subtypes. The long-term impact of aloe products has already been reported; however, there have been few studies about short-term exposure, and especially about the relative impact of Aloe vera whole-leaf freeze-dried powder (AWFP). To provide more toxicological data and to document the early changes induced by AWFP, in this study 120 SD rats were divided into four groups (control and 400/1200/2000 mg/kg treatment groups) and were administered AWFP once daily by oral gavage for 28 consecutive days, followed by a two week recovery phase. The results showed that AWFP could induce soft/loose changes in faeces. Significantly decreased white blood cell (WBC) counts, associated with reduced lymphocyte counts were also noted. The relative organ weight, including both organ-to-body weight ratio and organ-to-brain weight ratio of kidneys, was significantly increased in 2000 mg/kg compared with that in controls. Histopathologically, pigmentation in the kidneys and increased mucosal thickness in colon were also noted in a dose response groups. Other changes observed in the study were not considered to be treatment related, and 400 mg/kg was considered as the no-observed-adverse-effect level. The study provided clear evidence of treatment-related changes with a short-term exposure to AWFP. This is also the first report of the early colon morphologic changes associated with stool changes noted previously in-life phase, providing additional toxicity data which will contribute to our understanding about the short-term usage of AWFP as a remedy.

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Section: Discussionmentioning

confidence: 97%

Treatment‐related changes after short‐term exposure of SD rats to Aloe vera whole‐leaf freeze‐dried powder

Chen

Wang

2017

Int J Experimental Path

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“…One widely investigated species for its health‐related properties is Aloe vera , also known as Aloe barbadensis miller. Aloe vera has immunomodulatory properties in both in vitro and in vivo 10,11 . Due to containing glucomannans, acemannan, and mannose, Aloe vera may also have a prebiotic potential with increases in bifidobacteria, as well as short‐chain fatty acids, having been demonstrated during in vitro microbiota fermentation 12 .…”

Section: Food Supplementsmentioning

confidence: 99%

Food supplements and diet as treatment options in irritable bowel syndrome

Dimidi

Whelan

2020

Neurogastroenterology Motil

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Irritable bowel syndrome (IBS) is a chronic functional bowel disorder affecting 5.7% of the general population. Most patients relate their symptoms of IBS to foods they consume with diet being the most frequently reported factor impacting their life. However, although some foods may trigger symptoms, others may provide symptom relief. Indeed, several foods and diets have been investigated for their effectiveness in relieving IBS symptoms. In this issue of Neurogastroenterology and Motility, a double‐blind randomized placebo‐controlled trial in 160 patients with IBS demonstrated Aloe vera not to be effective in improving IBS symptoms. The aim of this review is to discuss the evidence on the effect of food supplements and diets in the management of IBS. Specifically, this review examines the evidence for aloe vera, peppermint oil, probiotics, fiber and prebiotics, healthy eating, the low FODMAP diet, and the gluten‐free diet.

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“…9,10 Recent scientific studies have revealed that Aloe vera contains 11 bioactive substances, which include the aloesin, 8-C-glucosyl-7-O-methyl-(S)-aloesol, and neoaloesin A. These three compounds have been extensively studied and are known to have for effective antibiotic and antitumor properties.…”

Section: 8mentioning

confidence: 99%

Anti-inflammatory and Anti-bacterial Effects of Aloe vera MAP against Multidrug-resistant Bacteria

Choi

Shin

2017

Nat Prod Sci

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− Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa are highly dangerous nosocomial pathogens, cause the symptoms of skin infections, pressure sores, sepsis, blood stream and wound infections. Unfortunately, these pathogens are immune to the most common antibiotics, such as, carbapenem, aminoglycoside and fluoroquinolone. Therefore, it is imperative that new and effective antibiotics be developed. In the present study, the antimicrobial effects of Aloe vera MAP (modified Aloe polysaccharide) on Staphylococcus aureus and Bacillus subtilis, Escherichia coli and Enterobacter aerogenes, and clinical Pseudomonas aeruginosa and clinical Acinetobacter baumannii were comprehensibly investigated. Prior to the growth inhibition effect measurement and antibiotic disc diffusion assay on gram-positive and gram-negative bacteria and selected multidrugresistant Pseudomonas aeruginosa and Acinetobacter baumannii, antimicrobial resistance screening was performed for the multidrug-resistant bacteria obtained from clinical isolates. The results for showed the Aloe vera MAP had a concentration-dependent effect on all of examined bacteria, particularly on Pseudomonas aeruginosa. Anti-inflammatory and anti-oxidant experiments were also performed dose dependently effects to confirm the beneficial physiological effects of Aloe vera MAP.

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Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro

Cited by 23 publications

References 27 publications

Treatment‐related changes after short‐term exposure of SD rats to Aloe vera whole‐leaf freeze‐dried powder

Treatment‐related changes after short‐term exposure of SD rats to Aloe vera whole‐leaf freeze‐dried powder

Food supplements and diet as treatment options in irritable bowel syndrome

Anti-inflammatory and Anti-bacterial Effects of Aloe vera MAP against Multidrug-resistant Bacteria

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