Effects of Aloe vera leaf gel extract on rat peritonitis model

Altıncık, Ayça; Sonmez, F. C.; Yenisey, Çiğdem; Duman, Soner; Can, Ayşe; Akev, Nuriye; Kırdar, Sevin; Sezak, Murat

doi:10.4103/0253-7613.132184

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…This anti-inflammatory effect could also be demonstrated in Wistar rats with induced peritoneal Staphylococcus aureus infection: Aloe gel extract alone increased the liberation of IL-1 β and, as expected, infected animals exhibited increased IL-1 β -levels. However, when the infected rats were treated with Aloe gel extract, the liberation of IL-1 β decreased to normal values again [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

López

Femenia

Núñez-Jinez

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Food industries typically use Aloe vera as concentrated (100× to 200×) and dried powders in their final products. These powders are obtained by extrusion of Aloe inner leaf gel (ILG) or Aloe whole leaf (WLP); the juice is filtered through diatomaceous earth and activated carbon before spray drying at temperatures below 70 °C. In another process, Aloe inner leaf gel was dried at ~80 °C and mashed to a powder rich in high molecular weight fibres and soluble polysaccharides (ILF). In contrast to ILG and WLP, the ILF sample was cytotoxic for the human intestinal cell line Caco-2 (CC50 = 1 g/l), even at concentrations below the recommended dose for human consumption. At lower concentrations (250 mg/l) with LPS challenged macrophage-like THP-1 cells decreased by 40% the release of the anti-inflammatory cytokine IL-10, whereas the release of the proinflammatory cytokine IL-1β increased by 35% (compared to untreated but challenged macrophage-like THP-1 cells). Unexpectedly, under the same conditions, the less cytotoxic ILG and WLP, both samples with a lower fibre content, significantly increased (up to 2.4 times) the release of IL-10, while the concentration of IL-1β remained unaltered and of TNFα decreased by 35%. Even more interesting is that a treatment of the ILF sample with activated carbon reduced its cytotoxicity and increased the IL-10 release (3.1 times). Based on these results, we suggest applying an activated carbon treatment on Aloe-starting products, which have high fibre content and have received high temperature treatment, in order to reduce their cytotoxicity and improve their immunomodulatory properties.

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Section: Discussionmentioning

confidence: 99%

In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

López

Femenia

Núñez-Jinez

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Povidiultane-iodine (PVPI) was also compared to lavage with 0.9% saline solution, which was positive 3 . Among plants, the extract of Aloe vera and Euphorbia tirucalli latex were objects of study in peritoneal lavage in an experimental model 18,19 . However, no studies were found with the fruit water of Cocus nucifera L., although its medicinal properties have already been evaluated 9,11,12,20 .…”

Section: Resultsmentioning

confidence: 99%

Peritoneal lavage with coconut water in rats with abdominal sepsis and its effects in peritoneum

et al. 2017

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Purpose: This study aims to analyze the effects of peritoneal lavage with coconut water on the peritoneal reaction in abdominal sepsis model in rats. Methods: We used 12 male Wistar rats weighing between 310±15 g. The animals were randomly distributed into 2 groups, with 6 animals each. Abdominal sepsis was induced by cecum ligation and puncture (CLP) in both groups. Group 1 was subjected to peritoneal lavage three times with 5 ml of saline each time; Group 2 submitted to peritoneal lavage with 5ml of coconut water also three times. Peritoneal lavage occurred 24 hours after CLP. Twenty four hours after, liquid from peritoneal cavity was harvested for counting of bacterial colony forming units (CFU/mL) of both groups. Euthanasia was done with overdose of anesthesia. For histopathological analysis, fragments of the peritoneum were removed, and a score was applied to the degree of inflammation. RESULTS: Group 2 had a lower histopathological score (p<0.005) and the fluid obtained in the first peritoneal lavage showed a lower amount of CFU compared to group 1 (p <0.005). CONCLUSION: The peritoneal lavage with coconut water positively influenced the inflammatory response in fragments of the peritoneum and the amount of CFU of bacteria in the peritoneal fluid in an experimental model.

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“…Altincik et al reported no toxic effects from the application of aloe vera gel to peritoneal surfaces and in a rat peritonitis model also demonstrated an anti-oxidant and anti-inflammatory effect of aloe vera [22].…”

Section: Discussionmentioning

confidence: 99%

“…Aloe vera possesses many pharmacological properties, including anti-inflammatory, immune-stimulant, wound healing, and antitumor, which could be involved in the mediation of ROS levels [21]. It has been claimed that aloe vera protects against pro-oxidant-induced membrane and cellular damage [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model

Bostancı¹,

Bakacak²,

Yıldırım³

et al. 2016

Clin. Exp. Obstet. Gynecol.

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Purpose of investigation:To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats. Materials and Methods: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control, Group 2: aloe vera endometriosis formation, and Group 3: aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats. Results: All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm 3 and after treatment the volumes dropped to 28.9 ± 14.9 mm 3 (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9±1.4 mm 3 and in Group 1, 118.9 ± 20.0 mm 3 (p = 0.001). Likewise, similar changes were observed in the histopatological scores. Conclusion: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions.

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Effects of Aloe vera leaf gel extract on rat peritonitis model

Cited by 11 publications

References 24 publications

In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

Peritoneal lavage with coconut water in rats with abdominal sepsis and its effects in peritoneum

Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model

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