Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

Abstract

AbstractsAluminium (Al) is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. Human exposure to Al has been increasing over the last decades. Al exposure and neurological impairments demonstrate mixed findings. The cerebral cortex is a sheet of neural tissue that is outer-most to the cerebrum of the mammalian brain and it plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness.The objectives of this study was to investigate the possible effects that aluminium Chloride could have on the histology of cerebral cortex. Total of twenty adult wistar rats were used for this experiment. The wistar rats were divided into five groups; group I was the control, group II received 475mg/Kg, group III received 950mg/kg, group IV received 1,425mg/kg and group V received 1,900mg/kg via oral intubation for a duration of Eight weeks. The wistar rats were humanly sacrificed and the brain was removed and immediately fixed in bouin fluid. The histological observations of the aluminium treated groups revealed extensive neuronal vacuolation and necrosis (neuro-degeneration) of the cerebral cortex of wistar rats.Based on our observations, we therefore conclude that Aluminium chloride exposure has neurodegenerative effects on the histology of cerebral cortex of adult wistar rats especially at higher dose. Therefore, caution should be taken in its usage.

Effects of combined exposure to aluminum chloride and γ-radiation on histological and ultrastructure of intestinal Paneth cells

“…Epidemiological studies have indicated a link between aluminum in drinking water and AD. A variety learning and memory deficits (Buraimoh, Ojo, Hambolu, & Adebisi, 2011;Yokel, 2000). Aluminum chloride was implicated to have negative effects on anxiety-related behavior of rats as it increased the rate of anxiety, neurodegenerative effects of cerebral cortex of adult rats especially at higher dose, and detrimental effects on the integrity of the testes of rats (Buraimoh et al, 2011(Buraimoh et al, , 2012Narahyana et al, 2014).…”

“…A variety learning and memory deficits (Buraimoh, Ojo, Hambolu, & Adebisi, 2011;Yokel, 2000). Aluminum chloride was implicated to have negative effects on anxiety-related behavior of rats as it increased the rate of anxiety, neurodegenerative effects of cerebral cortex of adult rats especially at higher dose, and detrimental effects on the integrity of the testes of rats (Buraimoh et al, 2011(Buraimoh et al, , 2012Narahyana et al, 2014). Human exposure to aluminum occurs primarily through ingestion of food and water, utilization of personal care products and cookware, and consumption of medications and administered vaccines (Saiyed &Yokel, 2005;Seubert, Monaci, Pizza, O'hagan, & Wack, 2008).…”

Effects of Ocimum basilicum extract on hematological and serum profile of male albino mice after AlCl3 induced toxicity

“…Aluminium (Al) is one of such metals frequently distributed through earth crust [3]. It is an integral component of many medicines, food additives and also added to drinking water for purification purposes [4]. Several sources of aluminium in daily life include spices, yellow cheese, aluminum ware, corn, salt, cosmetics, herbs, tea, antacid drugs and tooth paste [5].…”

Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

“…alters behaviour), have negative effects on anxiety-related behaviour of wistar rats as it increased the rate of anxiety in aluminium treated rats, had neurodegenerative effects on the histology of cerebral cortex of adult wistar rats especially at higher dose, was also said to have detrimental effects on the integrity of the testes of wistar rats , and also decrease the level of sperm count, but did not result into infertility. [16][17][18][19][20].This study was aimed at evaluating the possible effects that aluminium chloride could have on the histology of the liver of adult wistar rats.…”