Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury

Abstract

This study suggests that amantadine facilitates recovery of consciousness in pediatric acquired brain injury and provides important information necessary to design future more definitive studies.

Clinical and electroencephalographic on–off effect of amantadine in chronic non-traumatic minimally conscious state

“…Positive effect of amantadine in promoting clinical recovery in patients with disorder of consciousness (DOC) has been extensively evaluated in patients with prolonged posttraumatic vegetative state or minimally conscious state (MCS) [1][2][3][4][5], whereas few studies investigated amantadine effect in non-traumatic DOC [6,7], and only one reported on a chronic post-anoxic MCS patient [8].…”

Emergence to the Conscious State During Inpatient Rehabilitation After Traumatic Brain Injury in Children and Young Adults

“…The CNCS has previously been used in children with DOC after brain injury. 13,14 First CNCS score (typically obtained within the first few days of the admission) was used for the purpose of this study. The CNCS was not administered to 1 patient in this cohort; data are thus available for 13 patients.…”

Deleterious Cognitive and Motoric Effects of Haloperidol in an Adolescent With Cerebral Palsy: A Case Report

“…In a prospective, multicenter, placebo‐controlled study, amantadine was noted to speed the pace of functional recovery in adults with disordered consciousness after TBI [20]. In smaller studies, amantadine has been associated with increased wakefulness and improved neurobehavioral symptoms in children with head injuries [21‐23].…”