Effects of Ambient Exposure to Nitrogen Dioxide on Outpatient Visits for Psoriasis in Rapidly Urbanizing Areas

Wang, Yu; Li, Changchang; Ruan, Zengliang; Ye, Rouxuan; Yang, Bin; Ho, Hung Chak

doi:10.4209/aaqr.220166

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Select studies have linked CO with autoimmunity in general ( 23 ) and psoriasis in specific ( 15 ). Although average CO levels in the US have been declining during the era of rising rates of psoriasis ( 24 ), increased population growth in urban areas could still present a means for increased overall exposure to CO ( 11 , 25 ). Isopropyl alcohol and allylamine were weakly associated with psoriasis, but neither have reported links to psoriasis in the literature.…”

Section: Discussionmentioning

confidence: 99%

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

2022

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The cutaneous microbiome is increasingly recognized as a contributor to skin diseases like atopic dermatitis (AD) and psoriasis. Although traditionally AD and psoriasis have been viewed as having opposing immunologic findings, recent evidence suggests an overlap in ceramide-family lipid production in the protection against symptoms. We recently identified that specific environmental pollutants may drive dysbiosis through direct suppression of ceramide-family lipids produced by health-associated skin bacteria in atopic dermatitis (AD). We further demonstrated that one such bacteria, Roseomonas mucosa, generated significant clinical improvement in AD lasting beyond active treatment via lipid-mediated modulation of tumor necrosis factor (TNF) signaling. To assess the potential preclinical benefit of R. mucosa in psoriasis we assessed for direct effects on surface TNF signaling in cell cultures and identified direct effects on the TNF axis. We also identified preclinical efficacy of R. mucosa treatment in the imiquimod mouse model of psoriasis. Finally, we expanded our previous environmental assessment for psoriasis to include more traditional markers of air quality and found a strong association between disease rates and ambient carbon monoxide (CO), nitrogen dioxide (NO2), and particulate matter (PM). At the current stage this work is speculative but does support consideration of further preclinical models and/or clinical assessments to evaluate any potential for therapeutic benefit through microbial manipulation and/or environmental mitigation.

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Section: Discussionmentioning

confidence: 99%

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

2022

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“…Therein, NO accounts for the majority of NOx (Anthonysamy et al, 2018;Wu et al, 2022). It pollutes the air and directly affects humans, animals, and plants (Harikrishnan et al, 2005;Hu et al, 2019;Wang et al, 2022). Therefore, the discovery and development of NO treatment technologies are of great interest to scientists and engineers (Chou et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Photoredox-Catalyzed Decomposition of Nitric Oxide over Au-Enhanced Surface Plasmon Resonance ZnSn(OH)6 Microcubes

Pham

Nguyen²,

You³

et al. 2023

Aerosol Air Qual. Res.

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Air pollution is one of the most concerning issues today because of its adverse effects on living organisms and the environment. Therein, nitric oxide (NO) is the leading cause of the greenhouse effect, acid rain, and respiratory diseases. Therefore, discovering a low-cost, environmentally friendly, highly efficient photocatalysis technique to remove NO is necessary and urgent. In this work, the ZnSn(OH)6 microcubes (cZHS) catalyst was decorated with golden nanoparticles (Au:cZHS) to enhance the photoredox-catalyzed degradation of NO under solar light by surface plasmon resonance (SPR). This work demonstrated the contribution of SPR to the photoredox performance of the ZHS. Herein, the photoredox efficiency of the cZHS increased dramatically under the effecting of SPR from the golden nanoparticles, the photoredox efficiency of the Au:cZHS reached 75%, about four times higher than that of cZHS. In addition, the generation of other nitrogen species, nitrogen dioxide (NO2) conversion, and the reusability of the materials are calculated and discussed carefully by theory and experiment. On the other hand, the contribution and lifespan of radicals are also investigated clearly with trapping experiments and time-dependent electron spin resonance (ESR). This study provided the reader with a clear understanding of the SPR effect on the photocatalytic performance of cZHS, which may be necessary for future related studies.

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Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A proof of concept for NO2

Pallarés Porcar,

Sánchez-Íñigo,

Nuñez-Corcuera

et al. 2024

Chemosphere

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Effects of Ambient Exposure to Nitrogen Dioxide on Outpatient Visits for Psoriasis in Rapidly Urbanizing Areas

Cited by 4 publications

References 43 publications

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

Photoredox-Catalyzed Decomposition of Nitric Oxide over Au-Enhanced Surface Plasmon Resonance ZnSn(OH)6 Microcubes

Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A proof of concept for NO2

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