Effects of ambient lighting and the albino gene on the developing visual evoked potential of the mouse

The photically evoked afterdischarge: Current concepts and potential applications

“…The albino rat also has reliable slower peak latencies for those components of the evoked potential appearing in the first 100 msec following flash illumination (Creel et aI, 1970;Creel, Shearer, & Wilson, 1974). These latency differences have also been reported in the mouse (Henry, Rhoades, & Haythorn, 1977). There is evidence that the speed of energy conversion or charge transfer is faster with melanin pigment present (McGuiness, Corry, & Proctor, 1974).…”

Relation of albinism and drugs to the visual evoked potential of the mouse.

“…The VEP amplitude was smaller for the albino mouse. This is in contrast to an earlier study in this laboratory (Henry, Rhoades, & Haythorn, 1977) in which no significant genetic influence was found. However, this earlier study had greater variability because of both the smaller sample size and the lack of head restraint.…”

“…This contrasts with the abnormal VEP waveform reported for the albino rat (Creel et al, 1970) and for humans (Creel, Witkop, & King, 1974), which presumably results from the anomalous central visual pathways in these species (Guillery, Okoro, & Witkop, 1975;Lund, 1965). The VEP of the mouse may be unsuited for such an analysis because of the high degree of volume conduction in the small brain of this mammal (Henry et al, 1977).…”