Effects of Amifostine against Blunt Chest Trauma-Induced Cardiac Injury in Rats

Acıpayam, Ahmet

doi:10.14744/tjtes.2023.84308

Cited by 3 publications

(3 citation statements)

References 53 publications

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“…5,6 Experimental studies have shown that there are numerous ECG changes following decompression that are due to both the direct effect of the trauma on the myocardium and the prolonged muscle injury. [7][8][9] These changes include increased heart rate, ST segment elevation, ST segment depression, prolonged PR interval, T wave changes, arrhythmias, abnormal Q wave, QT prolongation, wide QRS wave. [7][8][9] In people trapped under rubble in earthquakes, adverse effects on the heart may occur as a result of hypovolemia, increased sympathetic activity, many electrolytes released into the blood after muscle injury, free radicals, and triggering of cytokines and various hormonal pathways as a result of immune system activation.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] These changes include increased heart rate, ST segment elevation, ST segment depression, prolonged PR interval, T wave changes, arrhythmias, abnormal Q wave, QT prolongation, wide QRS wave. [7][8][9] In people trapped under rubble in earthquakes, adverse effects on the heart may occur as a result of hypovolemia, increased sympathetic activity, many electrolytes released into the blood after muscle injury, free radicals, and triggering of cytokines and various hormonal pathways as a result of immune system activation. The negative effects of the earthquake on the heart and the increase in cardiovascular events persist not only at the time of the earthquake, but also in the months that follow.…”

Section: Discussionmentioning

confidence: 99%

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Electrocardiographic changes of patients who were under the rubble and were admitted to the hospital during Kahramanmaraş Earthquake

Akkaya,

Çakmak

2024

Journal of Health Sciences and Medicine

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Aims: In this study, we aimed to determine the electrocardiographic findings in earthquake victims who were admitted to our hospital after the Kahramanmaraş earthquake. Methods: We included all patients who applied to Diyarbakır Gazi Yaşargil Training and Research Hospital as earthquake victims in the study. The total number of injured patients removed from the rubble after the earthquake and admitted to our hospital was 321. A total of 139 patients were admitted to our hospital for examination and treatment. Fourty of them have a electrocardiograhphy. Clinical characteristics of the patients were compared according to the presence of crush syndrome. Patients who received further treatment in the intensive care unit (ICU) were compared with patients who did not require intensive care in terms of clinical characteristics. Electrocardiograpghy (ECG) findings were presented in all groups. Results: Crush syndrome developed in 45% of patients, while 25% developed acute renal failure. As expected, compartment syndrome was more common in patients with crush syndrome (66.7% vs 18.2%, p=0.002). The proportion of patients requiring dialysis treatment was 12.5% (n=5). The proportion of patients who received further treatment in the intensive care unit was 35% (n=14). In terms of ECG characteristics, heart rate was higher in ICU-treated patients (105/min vs 86/min, p

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electrocardiographic changes of patients who were under the rubble and were admitted to the hospital during Kahramanmaraş Earthquake

Akkaya,

Çakmak

2024

Journal of Health Sciences and Medicine

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“…Основными патогенетическими факторами посттравматического периода ушиба сердца являются циркуляторная гипоксия и нарушение течения энергозависимых процессов [1,2] в совокупности с механическим повреждением, приводящие к накоплению в кардиомиоцитах поврежденных органелл, несвернутых белков, лактата, ионов Ca 2+ , а также к нехватке субстрата для поддержания необходимого уровня гомеостаза и запуска репаративных процессов [3][4][5]. На моделях ишемического повреждения миокарда эти факторы описаны как триггеры, способные привести к увеличению активности феномена аутофагии -одного из вариантов запрограммированной клеточной гибели, суть которого заключается в деградации поврежденных органелл с целью дальнейшего использования их клеткой для восстановления метаболизма и формирования новых функционально полноценных структур [6].…”

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Influence of Stress Resistance on Myocardial Expression of the Pro-Autophagic Protein Beclin-1 After Cardiac Contusion in Experimental Setting

Klyuchnikova,

Korpacheva,

Mozgovoy

et al. 2023

Obŝaâ reanimatologiâ

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Objective. Evaluation of myocardial expression of the pro-autophagic protein Beclin-1 after cardiac contusion in experimental animals with diﬀerent stress resistance.Materials and methods. The study included 68 white mongrel male rats weighing 250–300 g. After ranking for extreme variants of stress resistance, moderately stress-resistant rats (N=36) were excluded from the study. The remaining animals were split into the control (N=16) and study (N=16) groups, each group composed of 8 high stress resistant and 8 low stress resistant rats. In the study group, 24 hours after inﬂicted cardiac contusion, 5×5 mm myocardial tissue specimens were sampled from the intraventricular septum, anterior walls of the left and right ventricles, histological sections were made, and a reaction with primary polyclonal Anti-Beclin-1 antibodies was performed. Beclin-1 expression was evaluated under the microscope.Results. Immunohistochemical evaluation revealed a statistically signiﬁcant increase in Beclin-1 protein expression (P=0.0002) in the cytoplasm of cardiomyocytes in the study group vs the control group, regardless of animals’ baseline stress resistance. However, expression of Beclin-1 protein in the myocardium of highly stress-resistant rats (Me=4.3; LQ=4.0; HQ=4.3) was signiﬁcantly higher versus low-resistant animals (Me=3.6; LQ=3.3; HQ=3.6) (P=0.0009).Conclusion. Increased expression of Beclin-1 protein in the post-traumatic period of experimental cardiac contusion indicates autophagic ﬂux activation. Intensity of autophagy varied depending on the animal’s stress resistance.

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Myocardial contractile function in the post-traumatic period of cardiac contusion in rats with different stress resistance: A preclinical experimental randomized trial

Zolotov,

Klyuchnikova,

Korpacheva

et al. 2024

Kuban. nauсh. med. vestnik

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Background. Pathogenesis of cardiac contusion involves primary traumatic and secondary hypoxic mechanisms of myocardial contractile function depression as well as body reactions aimed at adapting to altered environment. A significant part of these reactions is realized in the context of stress. The intensity of the stress component in myocardial dysfunction is largely determined by the individual stress reactivity of the body. Objectives. To assess the contractile function and functional reserves of the myocardium of rats with a high and low level of stress resistance in the post-traumatic period of cardiac contusion. Methods. A preclinical experimental randomized trial involved 134 white mature nonlinear male rats weighing about 270 g. The animals were divided by sequentially performed Open Field and Porsolt Forced Swim tests into 2 groups: group 1 — animals with low stress resistance, group 2 — animals with high stress resistance. Within each group, the animals were randomized into control and experimental subgroups. In the experimental subgroups, 6, 12 and 24 hours after simulating cardiac contusion, the force and rate indicators of myocardial contractility were evaluated using the Fallen isolated heart model. The summary measures of the study included assessing the contractile force and rate of isolated hearts of rats with low and high stress resistance, particularly under conditions of high-frequency rhythm load (ranging from 4.0 to 8.3 Hz) during the post-traumatic period of cardiac contusion. Data analysis was performed using software packages MS Office 2013 (Microsoft Corporation, USA) and Statistica, v. 10 (StatSoft, USA). The differences were considered to be statistically significant at p < 0.05. Results. 6, 12 and 24 hours after simulating a cardiac contusion, contractile force and rate of isolated hearts decreased in group 1 and group 2. In low stress-resistant animals, immediately following the stabilization period and during high-frequency rhythm test, the contractility force and rate in isolated hearts were statistically significantly lower (p = 0.0008) compared to those recorded in highly stress-resistant individuals. During the stimulation of a high-frequency rhythm, isolated hearts in the experimental group revealed diastolic dysfunction at all time points. In highly stress-resistant animals, diastolic dysfunction occurred at a heart rate of 300 min-1 and above, whereas in low stress-resistant animals, it manifested at a heart rate of 240 min-1 and above. At the same heart rate, diastolic dysfunction in low stress-resistant animals was statistically significantly greater (p = 0.0008) compared to that of highly resistant animals. Conclusion. The post-traumatic period following experimental myocardial contusion is characterized by a reduction in the force and rate of myocardial contractility, as well as a decrease in functional reserves of the myocardium, regardless of stress resistance. High stress resistance is associated with better preservation of cardiac contractile function and contractility reserves, whereas low stress resistance correlates with a more pronounced degree of myocardial dysfunction and a significant reduction in functional reserves of the contused heart. Differences in the severity of contractile dysfunction under conditions of high and low body resistance to stress can be attributed to varying degrees of secondary myocardial damage in the contused area, resulting from the misbalance between stress-activating and stress-limiting mechanisms involved in the development of secondary damage.

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Effects of Amifostine against Blunt Chest Trauma-Induced Cardiac Injury in Rats

Cited by 3 publications

References 53 publications

Electrocardiographic changes of patients who were under the rubble and were admitted to the hospital during Kahramanmaraş Earthquake

Electrocardiographic changes of patients who were under the rubble and were admitted to the hospital during Kahramanmaraş Earthquake

Influence of Stress Resistance on Myocardial Expression of the Pro-Autophagic Protein Beclin-1 After Cardiac Contusion in Experimental Setting

Myocardial contractile function in the post-traumatic period of cardiac contusion in rats with different stress resistance: A preclinical experimental randomized trial

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