Effects of Amlodipine on Exercise Performance and Cardiovascular and Skeletal Muscle Function in Physically Active Hypertensive Patients

Gillies, Hunter; Derman, E W; Noakes, Timothy D.

doi:10.2165/00044011-199612030-00003

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…Similarly, Gillies and coworkers demonstrated no significant impact of amlodipine on plasma lactate levels during leg cycling exercise in hypertensive patients 26 . Interestingly, in the same study, amlodipine was found to reduce resting BP without lowering BP during isometric exercise which is similar to the findings of our present study 26 …”

Section: Discussionsupporting

confidence: 92%

“… 26 Interestingly, in the same study, amlodipine was found to reduce resting BP without lowering BP during isometric exercise which is similar to the findings of our present study. 26 …”

Section: Discussionsupporting

confidence: 91%

“…26 Interestingly, in the same study, amlodipine was found to reduce resting BP without lowering BP during isometric exercise which is similar to the findings of our present study. 26 Amlodipine is an antagonist of the voltage-dependent L-type calcium channel (LTCC). At least four isoforms of LTCC have been identi- Our study demonstrated no significant effects of eplerenone in modulating sympathetic neural and pressor response to both isometric and dynamic exercise in hypertensive patients which is in contrast with the sympatho-inhibitory effect of this drug class demonstrated in our previous rodent studies.…”

Section: Discussionsupporting

confidence: 91%

“…However, this is unlikely as previous studies did not show an augmented increase in lactate production in isolated guinea pig hearts subjected to coronary ischemia in the presence of amlodipine 25 . Similarly, Gillies and coworkers demonstrated no significant impact of amlodipine on plasma lactate levels during leg cycling exercise in hypertensive patients 26 . Interestingly, in the same study, amlodipine was found to reduce resting BP without lowering BP during isometric exercise which is similar to the findings of our present study 26 …”

Section: Discussionsupporting

confidence: 89%

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Differential effects of eplerenone versus amlodipine on muscle metaboreflex function in hypertensive humans

Peri-Okonny

Velasco

Lodhi

et al. 2021

J of Clinical Hypertension

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Numerous studies have demonstrated that sympathetic nervous system overactivation during exercise in hypertensive rodents and humans is due, in part, to an exaggerated reflex response known as the exercise pressor reflex. Our prior studies have implicated a key role of mineralocorticoid receptor activation in mediating an augmented exercise pressor reflex in spontaneously hypertensive rats, which is mitigated by blockade with eplerenone. However, the effect of eplerenone on exercise pressor reflex has not been assessed in human hypertension. Accordingly, the authors performed a randomized crossover study to compare the effects of eplerenone to another antihypertensive drug from a different class amlodipine on sympathetic nerve activity (SNA) in 14 patients with uncomplicated hypertension. The authors found that amlodipine unexpectedly augmented the increase in SNA during the second minute of isometric handgrip, which persisted into the post‐exercise circulatory arrest period (∆ SNA, from rest of 15 ± 2 vs. 9 ± 2 vs. 10 ± 2 bursts/min, amlodipine vs. baseline vs. eplerenone, respectively, p < .01), suggesting an exaggerated muscle metaboreflex function. Eplerenone did not alter sympathetic responses to exercise or post‐exercise circulatory arrest in the same hypertensive individuals. In conclusions, our studies provide the first direct evidence for a potentially unfavorable potentiation of muscle metaboreflex by amlodipine during isometric handgrip exercise in hypertensive patients whereas eplerenone has no significant effect. Our study may have clinical implications in terms of selection of antihypertensive agents that have the least detrimental effects on sympathetic neural responses to isometric exercise.

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Section: Discussionsupporting

confidence: 92%

“… 26 Interestingly, in the same study, amlodipine was found to reduce resting BP without lowering BP during isometric exercise which is similar to the findings of our present study. 26 …”

Section: Discussionsupporting

confidence: 91%