2020
DOI: 10.1016/j.aquatox.2020.105621
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Effects of ammonia exposure on antioxidant function, immune response and NF-κB pathway in Chinese Strip-necked Turtle (Mauremys sinensis)

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Cited by 21 publications
(7 citation statements)
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“…In our study, with an increase in the concentration of BuP, the mRNA expression of HSP70 showed an upward trend, indicating that the turtles try to repair the damage caused by oxidative stress. The same result was observed in M. sinensis exposed in ambient ammonia [38]. Meanwhile, HSP90 accounts for 1-2% of the total tissue protein in a normal physiological state [39] and is a highly conserved molecular chaperone that can maintain the spatial conformation of proteins in cells, protect cells, and tolerate stress sources under environmental stress conditions [40].…”
Section: Discussionsupporting
confidence: 67%
“…In our study, with an increase in the concentration of BuP, the mRNA expression of HSP70 showed an upward trend, indicating that the turtles try to repair the damage caused by oxidative stress. The same result was observed in M. sinensis exposed in ambient ammonia [38]. Meanwhile, HSP90 accounts for 1-2% of the total tissue protein in a normal physiological state [39] and is a highly conserved molecular chaperone that can maintain the spatial conformation of proteins in cells, protect cells, and tolerate stress sources under environmental stress conditions [40].…”
Section: Discussionsupporting
confidence: 67%
“…Further in depth studies to dissect the precise role of STAT3 in mediating viral early infections could provide more valuable insights into viral pathogenesis. In addition, the activation of IL6-STAT3 signaling and HSP90 expression can be impacted not only by temperature uctuation, but also other environmental factors/stimuli during the faming process of aquatic animals, such as ammonia nitrogen, dissolved oxygen, salinity, pH, and stocking density (Liang et al, 2020;Long et al, 2019). However, our understanding concerning how the environmental stress responses in aquaculture industry alters the interaction between pathogens and host immune system, as well as the further development of infectious diseases is quite incomplete.…”
Section: Discussionmentioning
confidence: 99%
“…Further in-depth studies to dissect the precise role of STAT3 in mediating viral early infections could provide more valuable insights into viral pathogenesis. In addition, the activation of IL6-STAT3 signaling and HSP90 expression can be impacted not only by temperature fluctuation, but also by other environmental factors/stimuli during the farming process of aquatic animals, such as ammonia nitrogen, dissolved oxygen, salinity, pH, and stocking density [ 56 , 57 ]. Thus, our study suggests that induced expression of HSP90 by environmental stimuli conditions may increase the susceptibility to viral infection, which raises intriguing questions about the relationship between HSP90 expression, virus infection, and host health in aquaculture industry.…”
Section: Discussionmentioning
confidence: 99%