Effects of an adjunctive, chronotype-based light therapy in hospitalized patients with severe burnout symptoms - a pilot study

Canazei, Markus; Bassa, Daniela; Jiménez, Pablo Rodríguez; Papousek, Ilona; Fink, Andréas; Weiss, Elisabeth M.

doi:10.1080/07420528.2019.1604539

Cited by 9 publications

(3 citation statements)

References 57 publications

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“…In total, data from 14 035 participants was included in this review. The reporting transparency of included studies was poor; only three studies reported the use of EQUATOR network guidelines 21 , 50 , 60 and one study used the Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) reporting guidelines for non-randomized clinical trials 73 . No conflicts of interest or funding discrepancies were identified.…”

Section: Resultsmentioning

confidence: 99%

“…As the protocols assessed across the studies involved several different interventions, a definitive cause-and-effect relationship cannot be established. Seven (12.5%) 21 , 23 , 24 , 34 , 36 , 50 , 71 studies investigated bright light exposure, and were mainly conducted on geriatric or psychiatric patients. Reported improvements following bright light exposure were in sleep duration and sleep quality.…”

Section: Resultsmentioning

confidence: 99%

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Non-pharmacological interventions to improve sleep quality and quantity for hospitalized adult patients—co-produced study with surgical patient partners: systematic review

Acharya,

Blackwell,

Simoes

et al. 2024

BJS Open

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Background Hospitalized patients experience sleep disruption with consequential physiological and psychological effects. Surgical patients are particularly at risk due to surgical stress and postoperative pain. This systematic review aimed to identify non-pharmacological interventions for improving sleep and exploring their effects on sleep-related and clinical outcomes. Methods A systematic literature search was performed in accordance with PRISMA guidelines and was preregistered on the Open Science Framework (doi: 10.17605/OSF.IO/EA6BN) and last updated in November 2023. Studies that evaluated non-pharmacological interventions for hospitalized, adult patients were included. Thematic content analysis was performed to identify hypothesized mechanisms of action and modes of administration, in collaboration with a patient partner. Risk of bias assessment was performed using the Cochrane Risk Of Bias (ROB) or Risk Of Bias In Non-Randomized Studies – of Interventions (ROBINS-I) tools. Results A total of 59 eligible studies and data from 14 035 patients were included; 28 (47.5%) were randomized trials and 26 included surgical patients (10 trials). Thirteen unique non-pharmacological interventions were identified, 17 sleep measures and 7 linked health-related outcomes. Thematic analysis revealed two major themes for improving sleep in hospital inpatients: enhancing the sleep environment and utilizing relaxation and mindfulness techniques. Two methods of administration, self-administered and carer-administered, were identified. Environmental interventions, such as physical aids, and relaxation interventions, including aromatherapy, showed benefits to sleep measures. There was a lack of standardized sleep measurement and an overall moderate to high risk of bias across all studies. Conclusions This systematic review has identified several sleep interventions that are likely to benefit adult surgical patients, but there remains a lack of high-quality evidence to support their routine implementation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Non-pharmacological interventions to improve sleep quality and quantity for hospitalized adult patients—co-produced study with surgical patient partners: systematic review

Acharya,

Blackwell,

Simoes

et al. 2024

BJS Open

View full text Add to dashboard Cite

show abstract

“… 11 It is known that the circadian system is highly susceptible to the timing of a light stimulus 25 and recent evidence suggests that light therapy based on chronotype improves sleep. 26 Thus, this trial aimed to optimise the timing of light intervention based on the individual patient's chronotype.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of biologically-directed daylight therapy on sleep and circadian rhythm in Parkinson's disease: a randomised, double-blind, parallel-group, active-controlled, phase 2 clinical trial

Feigl,

Lewis,

Burr

et al. 2024

eClinicalMedicine

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Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis

Crinion,

Wyse,

Donohoe

et al. 2024

American J of Med Genetics Pt B

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Chronotype is a proxy sleep measure that has been associated with neuropsychiatric disorders. By investigating how chronotype influences risk for neuropsychiatric disorders and vice versa, we may identify modifiable risk factors for each phenotype. Here we used Mendelian randomization (MR), to explore causal effects by (1) studying the causal relationships between neuropsychiatric disorders and chronotype and (2) characterizing the genetic components of these phenotypes. Firstly, we investigated if a causal role exists between five neuropsychiatric disorders and chronotype using the largest genome‐wide association studies (GWAS) available. Secondly, we integrated data from expression quantitative trait loci (eQTLs) to investigate the role of gene expression alterations on these phenotypes. Evening chronotype was causal for increased risk of schizophrenia and autism spectrum disorder and schizophrenia was causal for a tendency toward evening chronotype. We identified 12 eQTLs where gene expression changes in brain or blood were causal for one of the phenotypes, including two eQTLs for SNX19 in hippocampus and hypothalamus that were causal for schizophrenia. These findings provide important evidence for the complex, bidirectional relationship that exists between a sleep‐based phenotype and neuropsychiatric disorders, and use gene expression data to identify causal roles for genes at associated loci.

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Effects of an adjunctive, chronotype-based light therapy in hospitalized patients with severe burnout symptoms - a pilot study

Cited by 9 publications

References 57 publications

Non-pharmacological interventions to improve sleep quality and quantity for hospitalized adult patients—co-produced study with surgical patient partners: systematic review

Non-pharmacological interventions to improve sleep quality and quantity for hospitalized adult patients—co-produced study with surgical patient partners: systematic review

Efficacy of biologically-directed daylight therapy on sleep and circadian rhythm in Parkinson's disease: a randomised, double-blind, parallel-group, active-controlled, phase 2 clinical trial

Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis

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