“…Despite the comparably large evidence base, the clinical meaning of the significant, yet relatively small changes is unclear [14]. Current evidence on psychopathology is also mainly in support of assertive models [3,6,15,18,25,42], yet conflicting results exist [1,48,46]. Finally, the last outcome parameter relevant in the present study, pharmacological adherence, was found to be a clinically important aspect, yet it is typically neglected in studies [14].…”