This study aimed to assess the influence of nicotine dependence with satisfaction of basic psychological needs, social support, attitude on smoking among middle school students. From Sep, 2015 to Nov, 2015, participants included 150 middle school students from D city and K province in Korea. Data for basic psychological needs, social support, attitude on smoking and nicotine dependence were collected through a self-reported questionnaire and were analyzed with independent t-test and analysis of variance, Pearson's correlation analysis, and multiple linear regression analysis. This study shows negative correlations between nicotine dependence and satisfaction of basic psychological needs (r=-.221, P=.008), competency(r=-.194, P=.021), relatedness(r=-.219, P=.009). The variables predicting nicotine dependence were satisfaction of basic psychological needs(β=.221, p=.008). These variables accounted for 42% of the variance of nicotine dependence in smoking middle school students. Our results indicated that it is necessary to increase basic psychological needs to decrease nicotine dependence. Therefore we should develop programs in order to increase satisfaction of basic psychological needs.