Effects of an intravaginal GnRH analogue administration on rabbit reproductive parameters and welfare

Munari, Chiara; Ponzio, Patrizia; Alkhawagah, A.R.; Schiavone, Achille; Mugnai, Cecilia

doi:10.1016/j.theriogenology.2018.10.024

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…Así, la aplicación de la hormona GnRH vía vaginal en conjunción con el semen es una importante mejora en el manejo reproductivo de las conejas pues disminuye el estrés de las mismas, habiendo sido calificada por expertos europeos como un "interesante aporte para el bienestar de las conejas" (de Jong et al, 2011). La respuesta fisiológica y productiva de diferentes análogos de GnRH y sus dosis óptimas para la vía vaginal siguen investigándose (Munari et al, 2019). No obstante, este manejo, además de moderar el estrés, reduce la mano de obra, mejora las condiciones de trabajo del ganadero, aminora el riesgo sanitario y disminuye el coste al no necesitar jeringuillas ni agujas (Martín, 2016), de modo que se está utilizando en muchas de las granjas comerciales que aplican inseminación artificial.…”

Section: Otros Aspectos De Bienestar Con Influencia Sobre Los Resultaunclassified

Bienestar y resultados zootécnicos en conejas de aptitud carne. Revisión bibliográfica

López¹,

Fras²,

Amorós³

2020

ITEA

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El manejo de reproductoras en grupo o semigrupo, con objeto de mejorar su bienestar, proporciona solo un ligero enriquecimiento del comportamiento locomotor y social, y algunos resultados zootécnicos próximos pero estadísticamente inferiores a los obtenidos en jaula individual, sin conseguir así compensar los resultados negativos del método: mayor mortalidad de gazapos lactantes, estrés, agresividad, heridas y mortalidad de las madres, unido a la complejidad, tiempo y trabajo requeridos por este manejo. Enriquecer la jaula individual mediante plataforma no deteriora los resultados zootécnicos, permite incrementar la movilidad y el repertorio comportamental de las conejas (saltar, erguirse), aumentando además la superficie disponible, pero empeora la higiene y aumentan los problemas sanitarios (pododermatitis, fracturas). Reposapatas y elementos para roer, así como refinar el enriquecimiento en las jaulas estándar, parece una vía útil para mejorar el bienestar mientras se profundiza en la gestión de la respuesta agresiva, así como en la idoneidad y en el modelo de grupo en las reproductoras de carne.

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Section: Otros Aspectos De Bienestar Con Influencia Sobre Los Resultaunclassified

Bienestar y resultados zootécnicos en conejas de aptitud carne. Revisión bibliográfica

López¹,

Fras²,

Amorós³

2020

ITEA

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“…In this study, we aimed to evaluate the efficiency of the Ovsynch estrous synchronization protocol as one of the most crucial estrous synchronization protocols in goats when GnRH and PGF 2α are delivered using a nano-based drug delivery system. Several studies have reported the advantages of engineered nanodrugs, including hormones, and their efficient biological activities due to the changes in physicochemical properties of materials in nanoforms [ 18 , 19 ]. Engineered nanohormones have a longer half-life time and sustained release, greater cellular uptake, and more efficient passage across epithelial or endothelial barriers [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Nanodelivery System for Ovsynch Protocol Improves Ovarian Response, Ovarian Blood Flow Doppler Velocities, and Hormonal Profile of Goats

Hashem

El‐Sherbiny

Fathi

et al. 2022

Animals

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Fifteen cyclic, multiparous goats were equally stratified and received the common Ovsynch protocol (GPG: intramuscular, IM, injection of 50 mg gonadorelin, followed by an IM injection of 125 µg cloprostenol 7 days later, and a further IM injection of 50 mg gonadorelin 2 days later) or the Ovsynch protocol using nanofabricated hormones with the same dosages (NGPG) or half dosages (HNGPG) of each hormone. The ovarian structures and ovarian and luteal artery hemodynamic indices after each injection of the Ovsynch protocol using B-mode, color, and spectral Doppler scanning were monitored. Levels of blood serum progesterone (P4), estradiol (E2), and nitric oxide (NO) were determined. After the first gonadotrophin-releasing hormone (GnRH) injection, the number of large follicles decreased (p = 0.02) in NGPG and HNGPG, compared with GPG. HNGPG resulted in larger corpus luteum (CL) diameters (p = 0.001), and improved ovarian and luteal blood flow, compared with GPG and NGPG. Both NGPG and HNGPG significantly increased E2 and NO levels compared with GPG. HNGPG increased (p < 0.001) P4 levels compared with GPG, whereas NGPG resulted in an intermediate value. After prostaglandin F2α (PGF2α) injection, HNGPG had the largest diameter of CLs (p = 0.001) and significantly improved ovarian blood flow compared with GPG and NGPG. Both NGPG and HNGPG increased (p = 0.007) NO levels, compared with GPG. E2 level was increased (p = 0.028) in HNGPG, compared with GPG, whereas NGPG resulted in an intermediate value. During the follicular phase, HNGPG increased (p = 0.043) the number of medium follicles, shortened (p = 0.04) the interval to ovulation, and increased (p < 0.001) ovarian artery blood flow and levels (p < 0.001) of blood serum P4, E2, and NO, compared with GPG and NGPG. During the luteal phase, the numbers of CLs were similar among different experimental groups, whereas the diameter of CLs, luteal blood flow, and levels of blood serum P4 and NO increased (p < 0.001) in HNGPG, compared with GPG and NGPG. Conclusively, the nanodelivery system for the Ovsynch protocol could be recommended as a new strategy for improving estrous synchronization outcomes of goats while enabling lower hormone dose administration.

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“…По-перше, відбувається деградація аналога ГнРГ при впливі ензимів, присутніх в плазмі сперми (Gogol, 2016). По-друге, аналогам ГнРГ властиве погане проникнення через слизову оболонку піхви, що обмежує його біодоступність і, призводить до необхідності збільшення концентрації за додавання в екстендер (Casares-Crespo et al, 2016;Munari et al, 2019).…”

Section: доба вагітностіunclassified

Comparative effectiveness of different methods of using the analogue of gonadotropin-releasing hormone for ovulation stimulation in rabbit does

Koshevoy,

Zhukova,

Naumenko

et al. 2024

SMLNUVMB

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Modern reproductive technologies require artificial insemination (AI) protocols that are safe for the health of animals and do not violate their welfare. Stress factors arising in the reproduction process of industrial rabbit breeding negatively affect the sexual function and reproductive performance of rabbits and their offspring. In recent years, researchers have focused on alternative methods of ovulation stimulation, including intravaginal introduction of hormonal means of its induction. Therefore, the aim of our study was a comparative evaluation of the effectiveness of the intramuscular method of administration of the gonadotropin-releasing control (GnRH) analogue and its addition to the sperm dose for AI on Hyplus rabbit (n = 30), which were randomly divided into three groups. For this, buserelin acetate was administered intramuscularly at a dose of 1 μg per rabbit immediately after artificial insemination (control group). Experimental animals were inseminated with sperm doses with the addition of a GnRH analogue in the amount of 25 μg (experimental group 1) and 15 μg (experimental group 2). The influence of the method of administration of GnRH analogue on reproductive function was evaluated by indicators of the effectiveness of AI, fertility, and the dynamics of the progesterone level during pregnancy. A decrease in fecundity was observed in females; for example, in experimental group 1, the effectiveness of AI in terms of the number of rabbits was 64.3 %; in animals of experimental group 2 – 41.2 %, and the number of inseminations in this group of rabbits was 41.7% higher compared to control data. The fertility of rabbits of all groups was high, reaching the maximum value in the control group (10.42 ± 0.52 heads/female). Fertility according to live newborns in experimental group 1 was the highest among all groups of rabbits and was 9.67 ± 0.49 heads/female, which showed an increasing trend compared to the control. Also, in the animals of experimental group 1, an increase in the level of progesterone in blood serum was observed (on the 7th day of pregnancy by 13.2 %, on the 14th day by 14.3 %, on the 21st day by 16.4 %). In contrast, in experimental group 2, a significant decrease in the progesterone level was noted. Thus, 25 μg of GnRH analogue added to the extender is optimal. It is worth noting that there were no advantages of intravaginal administration over intramuscular administration in terms of reproductive performance. However, the number of live births and progesterone levels were improved.

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Effects of an intravaginal GnRH analogue administration on rabbit reproductive parameters and welfare

Cited by 11 publications

References 25 publications

Bienestar y resultados zootécnicos en conejas de aptitud carne. Revisión bibliográfica

Bienestar y resultados zootécnicos en conejas de aptitud carne. Revisión bibliográfica

Nanodelivery System for Ovsynch Protocol Improves Ovarian Response, Ovarian Blood Flow Doppler Velocities, and Hormonal Profile of Goats

Comparative effectiveness of different methods of using the analogue of gonadotropin-releasing hormone for ovulation stimulation in rabbit does

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