Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction

Glucose for the Heart

“…After the effects of glucose and insulin on the ECGs of acutely ischemic dog hearts had been determined, a clinical role for GIK as a therapeutic agent was proposed in the 1960s. 138 The rationale was that such a "polarizing treatment" reverses loss of intracellular K ϩ during acute ischemia. Although the exact mechanisms for the effects of glucose and insulin in the ischemic myocardium are not known, it seems reasonable to assume that they enhance membrane stability.…”

Препараты Метаболического Действия В Комплексной Терапии Цереброкардиального Синдрома При Ишемическом Инсульте

“…В 1962 г. применили смесь глюкозы, инсулина и хлорида калия при остром инфаркте миокар-да. Авторы отметили регресс ишемических эпизодов на ЭКГ и уменьше-ние количества ЖЭС [256].…”

Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop

“…SodiPallares et al were amongst the first to describe the benefits of glucose/insulin/potassium (GIK) therapy in the context of acute myocardial infarction in 1962, [10] and has been an area of interest revisited many times over the following decades. One key aspect of insulin therapy however is the need for it to be administered early.…”