Effects of an isatin derivative on tumor cell migration and angiogenesis

Chang, Yunsong; Yuan, Yuan; Zhang, Qian; Rong, Yao; Yang, Yang; Ming, Chi; Liu, Zhen; Zhang, Yongmin; Yu, Peng; Teng, Yuou

doi:10.1039/c9ra08448g

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…To detect the inhibitory action of both the complexes on cell migration of HepG2 cells, the scratch assay was carried out. [59][60][61] When treated with IC 50 of Pd(II) and Pt(II) complexes, cell migration of HepG2 was reduced in 12 h and 24 h. 62 The result also revealed that the number of cells was significantly reduced in the denuded area, suggesting that both the complexes could minimize the site-specific cell migration as well as trigger cell death (Fig. 5).…”

Section: In Vitro Cell Migration Studymentioning

confidence: 94%

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

et al. 2022

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Section: In Vitro Cell Migration Studymentioning

confidence: 94%

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

et al. 2022

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“…Tube forming treatment of tumor is a strategy aimed at tumor vascular system. Angiogenesis in adult individuals occurs under pathological conditions, such as during inflammation and the immune response, tumorigenesis, metastasis, and injury repair [ 22 ]. As shown in the Figure 4 E, HUVEC cells were inoculated on matrix gel at a density of 2 × 10 5 cells/mL.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives

Ding

Zhao

et al. 2020

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A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures of these derivatives were confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition of proliferation activities of these derivatives against human leukemia cells (K562), human hepatocellular carcinoma cells (HepG2) and human colon carcinoma cells (HT-29) were evaluated in vitro using the MTT assay. Among the series, compound 4l exhibited strong antiproliferatory activities against K562, HepG2 and HT-29 cells with IC50 values of 1.75, 3.20, and 4.17 μM, respectively. The morphological, growth inhibitory and apoptosic effects of compound 4l in K562 cells, wound healing effect in HepG2 cells, and tube formating effect in matrix gel of HUVEC cells were evaluated consequently. All results indicated that compound 4l could be used as a potential antitumor agent in further investigations.

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“…This has given rise to very powerful and effective drugs such as the experimental drug Orantinib [ 43 , 44 ], the commercialized Sunitinib [ 45 ] or Nintedanib [ 46 ]. The transformations also were jointly carried out in positions 1 and 5, which have given rise to compounds with potent anti-neoplasic activity [ 47 , 48 , 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins

et al. 2023

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The application of high throughput synthesis methodologies in the generation of active pharmaceutical ingredients (APIs) currently requires the use of automated and easily scalable systems, easy dispensing of supported reagents in solution phase organic synthesis (SPOS), and elimination of purification and extraction steps. The recyclability and recoverability of supported reagents and/or catalysts in a rapid and individualized manner is a challenge in the pharmaceutical industry. This objective can be achieved through a suitable compartmentalization of these pulverulent reagents in suitable devices for it. This work deals with the use of customized polypropylene permeable-capsule devices manufactured by 3D printing, using the fused deposition modeling (FDM) technique, adaptable to any type of flask or reactor. The capsules fabricated in this work were easily loaded “in one step” with polymeric reagents for use as scavengers of isocyanides in the work-up process of Ugi multicomponent reactions or as compartmentalized and reusable catalysts in copper-catalyzed cycloadditions (CuAAC) or Heck palladium catalyzed cross-coupling reactions (PCCCRs). The reaction products are different series of diversely substituted isatins, which were tested in cancerous cervical HeLa and murine 3T3 Balb fibroblast cells, obtaining potent antiproliferative activity. This work demonstrates the applicability of 3D printing in chemical processes to obtain anticancer APIs.

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Effects of an isatin derivative on tumor cell migration and angiogenesis

Abstract: Compound 5-61, a 5-(2-carboxyethenyl)isatin derivative was previously shown to have potent anticancer activity. Its effect on angiogenesis was further explored in this study.

Cited by 10 publications

References 29 publications

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives

3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins

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