Effects of an Orabase Formulation with Ethanolic Extract of Malva sylvestris L. in Oral Wound Healing in Rats

Abstract

Malva sylvestris L. is widely used in medicine for treatment of inflammatory processes. The plant has anti-inflammatory properties due to substances such as mucilage, flavonoids, and tannins. A mouthwash with leaves from the plant can be used for the treatment of wounds in the oral mucosa. The aim of this study was to assess the wound healing effect of Malva sylvestris L. on a palate mucosa wound in rats. After intraperitoneal anesthesia, a 4-mm-diameter excisional wound was made in the center of the palatal mucosa of 136 rats, using a punch-out biopsy tool. Eight animals were used as baseline wound. The remaining rats were divided into four groups: CO, control; OB, orabase vehicle; CX, 2% chlorhexidine; and MA, 20% Malva in orabase. At 24 h postoperatively, the animals were immobilized without anesthetic to apply 25 mg of each substance twice a day, totaling 50 mg daily. The wound areas were measured photographically and the reepithelialization rates were determined histologically (%) after 0, 3, 7, 15, and 21 days. The data were analyzed by ANOVA and Tukey post hoc test. Similar healing pattern was observed among the groups (P>.05; ANOVA). According to the methodology, Malva sylvestris L. extract had no effect on wound healing in the palatal mucosa of rats.

Malva species: Insights on its chemical composition towards pharmacological applications

“…Besides, several studies documented wound healing effects to M. sylvestris . For example, Pirbalouti et al and Kovalik et al evaluated the wound healing activity of M. sylvestris extracts in rats and found a significant reduction in wound size in M. sylvestris extract‐treated mice (Kovalik et al, ; Pirbalouti et al, ; Pirbalouti et al, ; Pirbalouti & Koohpyeh, ). The mechanism through which M. sylvestris exert its wound healing potential is not clearly established.…”

Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)

“…On the other hand, mucilaginous compounds of Althaea officinalis, 47 Malva sylvestris, 48 and Trigonella foenum-graecum, 49 in addition to anti-inflammatory activity, can be involved in the relief of symptoms through laxative effects.…”

Malva: Food, Medicine and Chemistry

“…35 Modern research findings confirm the traditional knowledge. 161,183,[248][249][250][251][252][253][254][255][256][257][258] But carefully reviewing this data reveals an interesting and not always consistent results. For example, it is reported that chloroform and n-hexane extracts of M. parviflora are irritant.…”

“…Blade-induced injury in palatal mucosa of rats showed on healing effect of 70% ethanol/water extract of stems and leaves. 254 70% Ethanol/water extract of flower was prepared as cream with 5 and 10%. It was tested for treatment of burn (hot plate) injuries.…”