Effects of an organophosphorous compound on cardiac rhythm and haemodynamics in anaesthetized and conscious beagle dogs

Robineau, Pascale; Guittin, Pierre

doi:10.1016/0378-4274(87)90173-1

Cited by 18 publications

(6 citation statements)

References 7 publications

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“…Our results are in agreement with the work of Robineau and Guittin (1987) where they observed a significant decrease in heart rate, atrial and left intraventricular pressures, contractility index, lengthening of QT interval, ventricular tachycardia and atrioventricular blocks probably Figure 1 Effect of VX (20 µg/kg, i.v.) on blood pressure (BP), heart rate (HR), tracheobronchial response (TBR) and muscle twitch in rats.…”

Section: Tablesupporting

confidence: 82%

“…However, recent studies have demonstrated that the toxicological action on cardiac control mechanisms is equally important in producing lethality (Takahashi et al 1991). Several reports indicate that in most species the predominant effect of a systemic intoxication with OP is a fall in blood pressure and bradycardia (Robineau and Guittin 1987, Worek et al 1995aand 1995b. VX administration by i.v.…”

Section: Resultsmentioning

confidence: 99%

“…Nerve agents are organophosphorus (OP) compounds that exert acute toxic manifestations principally by inhibiting the enzyme acetylcholinesterase (AChE) resulting in a variety of physiological alterations and ultimately death from respiratory failure (Brimblecombe 1977). However, pharmacological studies indicate that nerve agents have plethora of actions other than inhibition of AChE (Worek and Szinicz 1995, Corbier and Robineau 1989, Robineau and Guittin 1987.Several studies have revealed that acute intravenous (i.v.) administration of an OP agent increased blood pressure in cat, dog and rat (Brezenoff and Giuliano 1982, Lang andRush 1973), while subcutaneous (s.c.) administration produced marked hypotension (Preston and Heath 1972).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cardiorespiratory and Neuromuscular Effects of O-Ethyl S-[2- (Diisopropylamino) Ethyl] Methylphosphonothioate (VX) in Rats

Dube

Mazumder

Kumar

et al. 1997

Bulletin of Environmental Contamination and Toxicology

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The exposure to chemical warfare agents is not restricted to the battlefield but as humans may be poisoned with nerve gases either from a chemical warfare stockpile or even in a public place. The recent use of nerve gas Sarin in a subway of Japan by a fanatic group has triggered global consternation about the extremists and homemade weapons of mass destruction. Nerve agents are organophosphorus (OP) compounds that exert acute toxic manifestations principally by inhibiting the enzyme acetylcholinesterase (AChE) resulting in a variety of physiological alterations and ultimately death from respiratory failure (Brimblecombe 1977). However, pharmacological studies indicate that nerve agents have plethora of actions other than inhibition of AChE (Worek and Szinicz 1995, Corbier and Robineau 1989, Robineau and Guittin 1987.Several studies have revealed that acute intravenous (i.v.) administration of an OP agent increased blood pressure in cat, dog and rat (Brezenoff and Giuliano 1982, Lang andRush 1973), while subcutaneous (s.c.) administration produced marked hypotension (Preston and Heath 1972). In a recent communication from this laboratory, it has been reported that i.v. administration of DFP/sarin produced a dose-dependent hypertension involving cholinergic-catecholaminergic interaction in rats. Subcutaneous administration of DFP/ sarin was found to produce a dose-responsive hypotension mediated through muscarinic receptors (Dube et al 1993). However, the mechanism of cardiovascular toxicity induced by nerve agents still remains obscure. Therefore, the effects on blood pressure, heart rate, tracheobronchial response, neuromuscular transmission, and modulatory role of various pharmacological agents were studied after systemic administration of VX (O-ethyl S-[2-(diisopropylamino) ethyl ] methyl phosphonothioate) to delineate the distinction in mechanism of action from other OP compounds.

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Section: Tablesupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cardiorespiratory and Neuromuscular Effects of O-Ethyl S-[2- (Diisopropylamino) Ethyl] Methylphosphonothioate (VX) in Rats

Dube

Mazumder

Kumar

et al. 1997

Bulletin of Environmental Contamination and Toxicology

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“…VX exposure produces positive inotropic effects. Arrhythmia was noted in rats and dogs (Robineau and Guittin, 1987). In guinea pigs treated with VX, delayed after-depolarization was found (Corbier and Robineau, 1989).…”

Section: Vxmentioning

confidence: 95%