Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury

Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus

“…Oxidative damage that occurred in the cerebellum due to ethanol exposure in rats and to an increase in tissue MDA retrograded right after testosterone administration. In addition, this hormone was the principal substance that prevented the neurofilament loss that occurred because of chronic ethanol intake in the same tissue (Celec et al, 2003). Another experimental study found, that testosterone was capable of increasing the GSH-Px activity in the hippocampus (Schmidt et al, 2002).…”

“…Additionally, testosterone has been found to demonstrate a preventive activity against oxidative stress that was induced by ethanol (Celec et al, 2003). Experimental studies have demonstrated damage in the brain tissue as a result of oxidative stress, and an immediate decrease in antioxidant enzyme levels has also been detected.…”

Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats

“…Blood samples were collected via the venous catheter in the three groups of animals and plasma levels of testosterone quantified by radioimmunoassay using standard commercially available kits [17,18].…”

Mechanisms of ethanol-induced degeneration in the developing, mature, and aging cerebellum

“…A 4-week exposure to daily ethanol feedings increased the production of malondialdehyde, a marker of lipid peroxidation, in rat cerebellum (183). On the contrary, Rouach et al (184) found no change in the indices of lipid peroxidation in rat cerebellum after a 4-week exposure to ethanol in drinking water, although the average intake of ethanol was comparable or even higher than in the protocol of Celec et al (183). One important factor contributing to the contrasting results may be the daily phases of ethanol withdrawal in the intragastric feeding regime vs. the continuous, even exposure to ethanol in drinking water.…”

“…In chronic ethanol exposure and/or during ethanol withdrawal, the oxidative stress-induced modification of lipids, proteins and other important macromolecules may result in irreversible damage to glial and neuronal cells (182). A 4-week exposure to daily ethanol feedings increased the production of malondialdehyde, a marker of lipid peroxidation, in rat cerebellum (183). On the contrary, Rouach et al (184) found no change in the indices of lipid peroxidation in rat cerebellum after a 4-week exposure to ethanol in drinking water, although the average intake of ethanol was comparable or even higher than in the protocol of Celec et al (183).…”