Effects of Anabolic Steroids Upon Circulating Thyroid Hormones

Rosenberg, I. N.; Ahn, Chi‐Hyung; Mitchell, Marvin L.

doi:10.1210/jcem-22-6-612

Cited by 30 publications

(2 citation statements)

References 6 publications

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“…In primary disorders of T, binding, there occur deviations from adult T, turnover rates comparable to those seen in childhood and senescence (13)(14)(15). However, under these circumstances, values for the per cent of free T4 and the resin uptake of T3 are distinctly abnormal (16,18,(21)(22)(23) and clearly different from those obtained in childhood and senescence in the present studies.…”

Section: Resultscontrasting

confidence: 65%

Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.

Braverman¹,

Dawber²,

Ingbar³

1966

J. Clin. Invest.

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In man, from childhood through senescence, there occur alterations in several metabolic functions that are regulated in part by the thyroid hormones. Thus, aging is associated with a decrease in basal oxygen consumption per unit surface area and an increase in total serum cholesterol and beta-lipoprotein cholesterol (1-5). Several indexes of thyroid function per se indicate greater thyroid activity in children and adolescents than in young adults and, conversely, less thyroid activity in the elderly. The extensive literature on this subject has been considered in recent publications (6, 7). It has been suggested, therefore, that there exist in childhood and senescence states of physiologic hyper-and hypothyroidism, respectively (4, 6, 8). It is not clear, however, whether this is truly the case. In this regard it may be significant that, in contrast to the situation in clinically recognizable thyroid disease, the serum protein-bound iodine (PBI) varies little, if at all, throughout the life-span of man (6,9,10).Recent studies related to these questions have indicated that the fractional rate of turnover of thyroxine (T4) in peripheral tissues decreases significantly from childhood through senescence (6,8,(10)(11)(12). Since variations in the binding of thyroid hormones to extracellular proteins greatly influence the kinetics of hormonal metabolism (13-15), the present studies were undertaken to determine whether the changes in the metabolism of T4 that accompany aging can be ascribed to MethodsSera were obtained from 99 subjects ranging between 2 and 87 years of age. Except in the prepubertal group, all were males. All donors were in good health. In the older subjects, as would be expected, chronic degenerative disorders were present to a variable degree, but none were ill and all were engaged in their routine daily activities. None were hospital in-or outpatients.' No donor of blood was taking any medication known to influence the binding of thyroid hormone in serum. Sera were obtained from freshly drawn blood and were divided into several aliquots, which were quickly frozen and thawed only once before their use in a specific test.Since it was not possible to carry out any single analysis on all specimens at one time, specimens were divided into decade groups according to the age of their donor. In most instances, an equal number of specimens from each age group was analyzed concurrently. This minimized the possibility that any small differences among measurements in the several age groups could have been due to day-to-day variations in the analytic techniques. Measurements of the per cent of free T4 in serum, the distribution of "endogenous" T4 among the binding proteins, and the serum PBI, as well as tests of the in vitro resin uptake of 'MI-labeled triiodothyronine (T3) were, with few exceptions, performed in the same sera. For measurement of the T4-binding capacities of the thyroxinebinding globulin (TBG) and thyroxine-binding prealbumin (TBPA), however, sufficient quantities of these specimens were somet...

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Section: Resultscontrasting

confidence: 65%

Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.

Braverman¹,

Dawber²,

Ingbar³

1966

J. Clin. Invest.

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“…Anabolic steroids are often used for the treatment of osteoporosis and general weakness from malnutrition in the elderly. Administration of testosterone decreases the amount of circulating thyroxine‐binding globulin, and so also does the administration of anabolic analogues of testosterone (11). Since these drugs interfere with the in vitro tests of thyroid function, it was decided to determine the duration of such interference in patients receiving anabolic steroids.…”

Section: Resultsmentioning

confidence: 99%

FACTORS INFLUENCING IN VITRO TESTS OF THYROID FUNCTION IN THE ELDERLY

Rosin¹,

Farran²

1968

J American Geriatrics Society

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Determinations of erythrocyte or resin }l31-triiodothyronine (T 3 ) uptake and the serum protein-bound iodine (PRI) concentration were made in 39 elderly patients on a geriatric ward and (for controls) on 20 relatively healthy residents of an old people's home.Difficulties in iuterpretation of these two tests of thyroid functiou may arise from a quantitative or qualitative alteration in thyroxine binding to protein. Some circumstances in which these test findings were altered in old people in the absence of clinical evidence of thyroid abnormality included accidental hypothermia, infections aud the ingestion of certain drugs commonly used iu geriatric practice, e.g., anabolic steroids. Results of the resin T 3 uptake test were also more variable in elderly hospital patients than in normal old or young people. The changes in thyroxine binding by protein during administration of anabolic steroids were not due to competitive binding but to a reversible reduction in the amount of thyroxine-binding protein.When determinations of thyroid function by in vitro tests are questionable, the free-thyroxine index (the product of the T 3 uptake aud the PRI level) gives a true assessment of thyroid status.Many old people who are euthyroid have a hypothyroid appearance. Consequently it is all the more important to recognise mild or moderate degrees of true hypothyroidism. The most convenient tests of thyroid function in the elderly are those based on the thyroidal uptake of radioactive iodine, the serum level of radioactive protein-bound iodine (PBp3!) or in vitro blood tests.The basal metabolic rate (BMR) is often difficult to perform in aged subjects, and serum cholesterol concentration and the electrocardiogram (ECG) are also subject to changes by other diseases.Of the in vitro blood tests, the chemically determined serum proteinbound iodine (PBI) level is the most reliable (1), particularly for hypothyroidism, but it is time-consuming and often requires the facilities of a specially equipped laboratory. The p31 triiodothyronine (T 3) erythrocyte uptake test is simple and fairly reliable in detecting changes from the euthyroid state. The original erythrocyte uptake test (2) requires carefully standardised

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Thyroid Function Tests

Fisher¹

1964

Am J Dis Child

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Effects of Anabolic Steroids Upon Circulating Thyroid Hormones

Cited by 30 publications

References 6 publications

Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.

Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.

FACTORS INFLUENCING IN VITRO TESTS OF THYROID FUNCTION IN THE ELDERLY

Thyroid Function Tests

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