Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay, Faruk; Şişman, Ali Rιza; Aksu, Aylin Çeçen

doi:10.5551/jat.25809

Cited by 7 publications

(6 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that the plasma PON1 activity is elevated in athletic adolescents who engage in regular physical activity, and in football players three days after a tournament [7,15]. In addition, five months of anaerobic training induced an elevation in the circulating PON1 activity [83]. Moreover, the PON1 activity was found to have increased following a single maximal exercise; and this effect was much more pronounced in active than in sedentary subjects [63,64].…”

Section: Paraoxonase 1 Myeloperoxidase and Physical Activitymentioning

confidence: 83%

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Malara

Kęska

Lutosławska

2016

Biomedical Human Kinetics

View full text Add to dashboard Cite

SummaryThe purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes -paraoxonase 1 and myeloperoxidase -on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol) bring about atherosclerosis and an increased risk of cardiovascular disease (CVD) which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C) and increasing the HDL-cholesterol (HDL-C). However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes -paraoxonase 1 (PON1) and myeloperoxidase (MPO) -which markedly affect the properties of HDL-C and contribute to its anti -or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

show abstract

Section: Paraoxonase 1 Myeloperoxidase and Physical Activitymentioning

confidence: 83%

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Malara

Kęska

Lutosławska

2016

Biomedical Human Kinetics

View full text Add to dashboard Cite

show abstract

“…Tomas et al reported an opposite effect of exercise training on PONA according to PON1-192 polymorphism 39 ) . A recent report with Turkish national judoists showed that an anaerobic judo training increased significantly PONA, AREA, and HDL-C, and that interaction of PON1-192 polymorphism was seen in not AREA but PONA 33 ) . In addition to genetic factors, regulation of PON1 activity is affected by environmental factors such as anxiety 40 ) , oxidative stress 41 ) , and inflammation 42 ) .…”

Section: Discussionmentioning

confidence: 96%

“…Table 5 shows limited studies that investigated the effects of exercise training on quantity of HDL and HDL function (CEC and/or PON1) 13 , 24 – 33 ) . These inconsistent results may be partially due to differences in studied population, HDL-C levels at baseline, exercise status, and concomitant therapy such as diet and medication.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome

Furuyama

Koba

Yokota

et al. 2018

J Atheroscler Thromb

View full text Add to dashboard Cite

Aims: We evaluated whether exercised-based cardiac rehabilitation (CR) can ameliorate the HDL function, i.e., cholesterol efflux capacity (CEC) and paraoxonase-1 activity in patients with acute coronary syndrome (ACS).Methods: This study is a retrospective analysis of stored serum from patients with ACS following successful percutaneous coronary intervention. The CEC, measured by a cell-based ex vivo assay using apolipoprotein B-depleted serum and 3H-cholesterol labeled macrophages and arylesterase activity (AREA) at the onset or early phase of ACS, and the follow-up periods were compared between 69 patients who completed the five-month outpatient CR program (CR group) and 15 patients who did not participate and/or dropped out from CR program (non-CR group).Results: Apolipoprotein A-I (apoA-I) and CEC significantly increased by 4.0% and 9.4%, respectively, in the CR group, whereas HDL-cholesterol and AREA were not changed during the follow-up periods in both groups. Among CR patients, the CEC significantly increased, irrespective of the different statin treatment, while HDL-cholesterol and apoA-I significantly increased in patients treated with rosuvastatin or pitavastatin. Although CEC and AREA were significantly correlated each other, there is a discordance between CEC and AREA for their correlations with other biomarkers. Both CEC and AREA were significantly correlated with apoA-I rather than HDL-cholesterol. Changes in CEC and those in AREA were significantly correlated with those in apoA-I (rho = 0.328, p = 0.002, and rho = 0.428, p < 0.0001, respectively) greater than those in HDL-cholesterol (rho = 0.312, p = 0.0042, and rho = 0.343, p = 0.003, respectively).Conclusions: CR can improve HDL function, and it is beneficial for secondary prevention.

show abstract

“…There is now substantial body of evidence suggesting that anaerobic (8) and aerobic exercise trainings at short and long duration (4, 7) are significant factors against atherosclerosis through increasing antioxidant factors. Furthermore, PON1 is a calcium-dependent esterase (4), bound to the surface of HDL (5), and acts as an antioxidant enzyme (2,6).…”

Section: Discussionmentioning

confidence: 99%

“…In this context, it has been shown that long-term aerobic (4) and anaerobic (8) exercise trainings increase PON1 activity and HDL levels in sedentary (4) and active females (8), respectively. In addition, an increased PON1 activity and HDL levels has been revealed following short-term exercise training in football players (7).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

et al. 2017

View full text Add to dashboard Cite

Background: Paraoxonase-1 (PON1) is an anti-atherosclerotic enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein (LDL) against oxidation. There are contradictory studies about the effects of exercise training on PON1 activity. Objectives: The purpose of the present study was to elucidate the effects of sprint and endurance exercise training on serum PON1 activity and lipid profile in rats. Methods: Twenty-four Albino Wistar rats were divided to sedentary control (SC), endurance training (ET), and sprint training (ST) groups. The animals were subjected to endurance (at a speed of 27 m/minute) and sprint (at a speed of 40 to 54 m/minute) training on a treadmill for 6 weeks, 6 days per week. Using commercial kits, PON1 activity and lipid profile levels were measured by spectrophotometry and enzymatic methods, respectively. The data were analyzed by one-way analysis of variance followed by Tukey's post-hoc test at P < 0.05 level. Results: Both ET and ST regimens increased PON1 activity in the serum, and the alteration was greater following ST than ET (F1, 23 = 17.87, P = 0.001). In contrast, neither ST nor ET changed significantly the serum levels of triglyceride (F1, 23 = 0.288, P = 0.753), total cholesterol (F1, 23 = 0.385, P = 0.685), LDL (F1, 23 = 1.07, P = 0.361), and HDL (F1, 23 = 1.36, P = 0.277). In addition, serum PON1 activity was positively correlated with serum HDL levels in rats (R = 0.44, P = 0.032). Conclusions: Despite the lack of change in serum lipid profile, sprint training can lead to greater protection against lipid peroxidation than endurance training through increases in serum PON1 activity.

show abstract

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Cited by 7 publications

References 56 publications

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

Contact Info

Product

Resources

About