Effects of androgen deprivation on chronic bacterial prostatitis in a rat model

Seo, Seong Il; Lee, Seung‐Ju; Kim, Joon Chul; Choi, Y M; Hwang, Tae‐Kon; Cho, Yong Hyun

doi:10.1046/j.1442-2042.2003.00666.x

Cited by 32 publications

(27 citation statements)

References 22 publications

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“…Seo et al 77 conducted studies of chronic bacterial prostatitis using the Nickel's model. Approximately, 62% of 12-to 16-week-old male Wistar rats develop chronic bacterial prostatitis by 4 weeks after instillation of 2 Â 10 7 colony-forming units of E. coli Z-17 into the urethra.…”

Section: Rat Models Of Prostatitis (Categories I and Ii)mentioning

confidence: 99%

“…In general, authors demonstrated that among other models of androgen deprivation, finasteride was 1.5-to twofold more effective modality to improve course of chronic bacterial prostatitis in the animal model without reducing the systemic testosterone levels. 77 More recent studies have evaluated the antibacterial effects of intraprostatic zinc injection 78 and synergistic effects of catechin treatment (extract of green tea) combined with the antibiotic ciprofloxacin in the experimental rat model of chronic bacterial prostatitis. 79 Accumulated evidence suggests that rodent models of experimentally induced prostate inflammation (categories I and II) share many striking similarities to the development and persistence of human chronic bacterial prostatitis, possible comparable to the natural history of the disease.…”

Section: Rat Models Of Prostatitis (Categories I and Ii)mentioning

confidence: 99%

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Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

Resnick

MacLennan

et al. 2007

Prostate Cancer Prostatic Dis

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Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly-and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental rodent models of prostatitis and evaluates their advantages and limitations.

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Section: Rat Models Of Prostatitis (Categories I and Ii)mentioning

confidence: 99%

Section: Rat Models Of Prostatitis (Categories I and Ii)mentioning

confidence: 99%

Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

Resnick

MacLennan

et al. 2007

Prostate Cancer Prostatic Dis

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“…The urethra was catheterized with a sterile 22-gauge angiocatheter sheath and the bladder was emptied; 0.4 ml of bacterial solution (1 × 10 9 colony forming units; all of the groups except the control group) or sterile saline solution (control group) was instilled into the base of prostate via urethra [13,14]. The angiocatheter was removed and the urethra was occluded with collodium.…”

Section: Methodsmentioning

confidence: 99%

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute <b><i>Pseudomonas</i></b> Prostatitis Rat Model

Rifaioğlu¹,

Nacar²,

Yuksel³

et al. 2013

Urol Int

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Introduction: The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa. Material and Methods: A total of 42 male Wistar albino rats were divided into 7 groups as follows: control, ABP (24, 48, and 72 h), and TQ-ABP (24, 48, and 72 h). The prostate tissue samples were assayed for prostate tissue malondialdehyde (MDA) and nitric oxide(NO) levels, and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities. Sections were examined for characteristic histological changes, and a histological scoring system was used. Results: When the ABP groups given TQ (24, 48, and 72 h) were compared to the ABP groups not given TQ, the levels of MDA and NO and the GPX activity were found to be significantly lower in the groups given TQ. Concerning SOD values, the TQ-ABP-72 group was lower in comparison with the ABP-72 and control groups, but statistically higher than the TQ-ABP-48 group (p < 0.05). Concerning CAT activity, only the TQ-ABP-72 and ABP-72 groups had a significant difference with the control group. TQ improved prostate histology significantly only in the TQ-ABP-24 group compared to the ABP-24 group (p < 0.001). Conclusion: Our study demonstrated for the first time that ABP induced by P. aeruginosa had an oxidative effect on prostate tissue and could regress following TQ administrationas shown withthe biochemical and histological findings.

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“…According to each category, the level of prostatitis was described by recording samples as follows: without proof 0 score, ＜10% 1 score, 10-25% 2 score, 26-50% 3 score, 51-75% 4 score, and 76-100% 5 score (Table 1). 9 …”

Section: Histological Studymentioning

confidence: 99%

Anti-Inflammatory Effect of Phlorotannin on Chronic Nonbacterial Prostatitis in a Rat Model

Jung

Cho

Han

2014

Korean J Urogenit Tract Infect Inflamm

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Purpose: Chronic nonbacterial prostatitis and chronic pelvic pain syndrome account for 90-95% of all prostatitis. Little is known about its pathophysiology, thus, various treatments are used. Ecklonia cava, a seaweed, is a member of the brown algae family; many recent reports have demonstrated that its extract containing phlorotannin has anti-oxidative and anti-inflammatory properties. Using the hormone-induced prostatitis rat model, we investigated the anti-inflammatory effects of E. cava extracts via its anti-oxidative process on chronic nonbacterial prostatitis. Materials and Methods: Forty, 10-week-old male white Wistar rats were utilized, and divided equally into the following five groups: 1) control, 2) E. cava-fed, 3) hormone-induced prostatitis (HIP), 4) E. cava-treated HIP, and 5) nonsteroidal anti-inflammatory drug (NSAID)-treated HIP. Results:The results showed statistically-significant improvement in the tissue response to the hormone-induced inflammation among the E. cava-treated and NSAID-treated groups (p＜0.05). Lower malonedialdehyde levels were observed in the group with E. cava-treated HIP than with HIP alone, which was statistically significant. We believe that this supports the anti-oxidative properties of E. cava. Conclusions: This study demonstrates that phlorotannin has anti-inflammatory properties via its anti-oxidative process, which we expect to play an important role in prevention and as an adjuvant therapy for chronic nonbacterial prostatitis.

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Effects of androgen deprivation on chronic bacterial prostatitis in a rat model

Cited by 32 publications

References 22 publications

Experimental rodent models of prostatitis: limitations and potential

Experimental rodent models of prostatitis: limitations and potential

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute <b><i>Pseudomonas</i></b> Prostatitis Rat Model

Anti-Inflammatory Effect of Phlorotannin on Chronic Nonbacterial Prostatitis in a Rat Model

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