Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding

Peuranpää, Pirkko; Heliövaara-Peippo, Satu; Fraser, Ian S.; Paavonen, Jorma; Hurskainen, Ritva

doi:10.1111/aogs.12394

Cited by 79 publications

(80 citation statements)

References 22 publications

(22 reference statements)

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“…Managing menstrual problems is core work for gynaecologists but we frequently fail to diagnose, manage and treat iron deficiency and iron‐deficiency anaemia, resulting in a slow return to an improved quality of life. This was highlighted in a 2014 randomised controlled study that considered the impact of HMB managed by the fitting of a levonorgestrel intrauterine system or hysterectomy in anaemic and non‐anaemic women . Twelve months after treatment haemoglobin levels remained significantly lower in women who were initially anaemic and, although ferritin levels increased in both groups, it took five years for levels to return to normal in those who were initially anaemic.…”

Section: Resultsmentioning

confidence: 99%

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Iron deficiency and iron‐deficiency anaemia in women's health

Percy¹,

Mansour

2017

The Obstetric & Gynaecologis

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Key content Iron deficiency is the most common micronutrient deficiency worldwide. More than 20% of women are iron deficient in their reproductive years. There are a number of oral iron preparations available but iron content in them varies and they can result in gastrointestinal adverse effects. The formulation and dose of iron should be chosen to best suit the woman and her level of iron deficiency. As gynaecologists, we focus on reducing menstrual blood loss in women with heavy menstrual bleeding, but frequently fail to diagnose, manage and treat iron deficiency/iron‐deficiency anaemia, resulting in a slow return to improved quality of life. Learning objectives To be able to summarise the mechanisms underlying iron metabolisms and the importance of iron in cellular functioning. To help clinicians recognise the importance of iron deficiency and its management. Ethical issues Severe preoperative iron‐deficiency anaemia may place a patient at increased risk of blood transfusion during surgery and adverse postoperative sequelae. Recognising and treating this with intravenous iron can prevent such an intervention, but at the cost of providing treatment in a safe, appropriately staffed environment to manage rare adverse events such as anaphylaxis.

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Section: Resultsmentioning

confidence: 99%

“…HMB is thought to account for 20–30% of cases of iron‐deficiency anaemia worldwide . Sixty three percent of women with HMB were iron deficient or had iron‐deficiency anaemia in one study, while in another study, 27% of women with HMB were anaemic and a further 60% were severely iron deficient …”

Section: Aetiologymentioning

confidence: 93%

Iron deficiency and iron‐deficiency anaemia in women's health

Percy¹,

Mansour

2017

The Obstetric & Gynaecologis

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“…In women with ferropenies it was necessary 5 years to achieve normal ferritin levels. Such results allowed the authors to recommend the supplementation with iron in such situations and monitoring at 4 months to assure the quality of life [26].…”

Section: Who Recommend Iron Supplementationmentioning

confidence: 94%

Ferritin: Could be a Health Indicator

M¹,

L²

2018

J Fam Med Dis Prev

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• AbstractHealth indicators show a health-related characteristic that allows the study, evaluation and conclusion of a health process. Therefore, it allows us to influence public health policies to obtain an improvement in the health status of the population.Iron deficiency is one of the most prevalent forms of malnutrition, without quality of life and can present in anaemia, with reduce of hemoglobin (it causes 50% of anaemia around the world) and in ferropenia, iron deficiency, without anaemia. The iron deficiency has a very heavy rates of mortality associated of it.The iron element is a d-block transition element with an oxidation changeable ranging between -2 and 6+ which makes iron to be in different biological ways: ferrous (Fe 2+ ), ferric (Fe 3+ ), or ferryl (Fe. This capacity allows iron to bind to manifold ligands/proteins of the human organism, which are essential for all living cells; to participate in many metabolic and energetic pathways, like a production of energy in mitochondria, binding and transport of oxygen, regulation of cell growth and differentiation, synthesis and packaging of neurotransmitters and degradation of catecholamines [2], synthesis of the deoxyribonucleic acid or DNA [3] and others.As free iron is toxic to cells, it is stored complexed to protein as ferritin. Thus, the serum ferritin level correlates with a total body iron, could discard ferropenia (iron deficiency without anaemia) and establish he quality of life.Women, especially in their fertile stage, tend to have lower values because of menstrual losses, even during normal menses. In this small text we will try to reflect on how ferritin can be a parameter of evaluation of quality of life and normality of body functions.

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“…Iron deficiency and iron-deficiency anemia typically occur as a consequence of a severe underlying condition, such as inflammatory bowel disease (IBD), gastrointestinal (GI) bleeding, chronic heart failure (CHF), chronic kidney disease (CKD), or cancer [2][3][4][5][6][7][8][9]. Heavy menstrual bleeding and pregnancy may also result in iron deficiency [10,11]. Effective treatment of iron deficiency/iron-deficiency anemia is important to relieve symptoms, including extreme fatigue and tiredness, as well as to alleviate the adverse impact on quality of life [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Heavy menstrual bleeding and pregnancy may also result in iron deficiency [10,11]. Effective treatment of iron deficiency/iron-deficiency anemia is important to relieve symptoms, including extreme fatigue and tiredness, as well as to alleviate the adverse impact on quality of life [11][12][13][14][15][16]. Furthermore, anemia is a risk amplifier for mortality and morbidity in patients with heart disease [17] and those with CKD [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency

et al. 2020

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Iron deficiency and iron-deficiency anemia are associated with increased morbidity and mortality in a wide range of conditions. In many patient populations, this can be treated effectively with oral iron supplementation; but in patients who are unable to take or who do not respond to oral iron therapy, intravenous iron administration is recommended. Furthermore, in certain conditions, such as end-stage kidney disease, chronic heart failure, and inflammatory bowel disease, intravenous iron administration has become first-line treatment. One of the first available intravenous iron preparations is iron sucrose (Venofer ® ), a nanomedicine that has been used clinically since 1949. Treatment with iron sucrose is particularly beneficial owing to its ability to rapidly increase hemoglobin, ferritin, and transferrin saturation levels, with an acceptable safety profile. Recently, important new data relating to the use of iron sucrose, including the findings from the landmark PIVOTAL trial in patients with end-stage kidney disease, have been reported. Several years ago, a number of iron sucrose similars became available, although there have been concerns about the clinical appropriateness of substituting the original iron sucrose with an iron sucrose similar because of differences in efficacy and safety. This is a result of the complex and unique physicochemical properties of nanomedicines such as iron sucrose, which make copying the molecule difficult and problematic. In this review, we summarize the evidence accumulated during 70 years of clinical experience with iron sucrose in terms of efficacy, safety, and cost-effectiveness.

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Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding

Abstract: Improved HRQoL after treatment of HMB is associated with correction of anemia. Clinicians should actively screen for anemia in women with HMB and emphasize early iron substitution as an integral part of treatment.

Cited by 79 publications

References 22 publications

Iron deficiency and iron‐deficiency anaemia in women's health

Iron deficiency and iron‐deficiency anaemia in women's health

Ferritin: Could be a Health Indicator

Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency

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