Effects of Anesthesia, Surgery and Inflammation Upon Host Defense Mechanisms

Abstract

Complement protein levels and C7 hemolytic activity were measured in four individuals following anesthesia and surgery, and in a group of 20 patients with inflammatory diseases. Seven of the eight complement components studied characteristically were elevated, most dramatically C1s and C3PA. Elevation of C1s often was greater than elevation of C1q, displaying an independent variation of C1s and C1q in both postoperative and inflammatory disease patient groups. The major increases of C components were seen subsequent to the peak C-reactive protein response, as was the occurrence of the ‘reactor state’, a propensity to formation of C56 which surprisingly was associated with increased levels of C7. Levels of properdin frequently were reduced postoperatively. It is concluded that multiple complement components, with the notable exception of properdin, respond as acute phase reactants which are elevated and changed in proportion postoperatively and during inflammatory disease.

Complement Components and Complement Activation in Acute Poststreptococcal Glomerulonephritis

“…orosu mucoid and AAT [1, 13,14,44], In the present investigation, the concentrations of Clq. Cls, C2, C4, and B were largely nor mal or high during the early phase of AGN together with a more pronounced increase of orosomucoid and AAT.…”

Successful Management of Obstructive Jaundice due to Gallstones with Eculizumab in a Patient with Paroxysmal Nocturnal Hemoglobinuria

“…Our case required EST, ERBD, and open cholecystectomy to treat her gallbladder disease; hence, she was at risk of developing hemolytic crisis as a result of bacterial infection, severe obstructive jaundice, and surgery. An increase in the level of complement proteins, which worsens hemolysis, has been reported to occur following anesthesia, surgery, and various inflammatory conditions (10). The anesthetic management could be harmful for PNH patients, and cardiac arrest due to a hemolytic episode during the induction of anesthesia has been reported (11).…”

Acute phase reactants and complement components as indicators of recurrence in human cervical cancer

“…It is noteworthy that the serum levels of the CC, seem to follow the same pattern as those of APR. Indeed, it has been described in some other diseases that several individual CC respond as APR [18][19][20].…”