2016
DOI: 10.1016/j.nucmedbio.2015.09.009
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Effects of anesthetics on vesicular monoamine transporter type 2 binding to 18 F-FP-(+)-DTBZ: a biodistribution study in rat brain

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Cited by 12 publications
(4 citation statements)
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“…Different type of anesthetization brought different response to brain uptake. Brain uptake of 18 F-FDG decreased in condition of isoflurane and ketamine/xylazine anesthetization, no change of striatal 18 F-PF-(+)-DTBZ uptake was observed in isoflurane but ketamine increased 18 F-PF-(+)-DTBZ striatal uptake (Toyama et al, 2004; Chen et al, 2016). All of these results indicated anesthetization is one of the confounding factor to brain uptake.…”
Section: Discussionmentioning
confidence: 96%
“…Different type of anesthetization brought different response to brain uptake. Brain uptake of 18 F-FDG decreased in condition of isoflurane and ketamine/xylazine anesthetization, no change of striatal 18 F-PF-(+)-DTBZ uptake was observed in isoflurane but ketamine increased 18 F-PF-(+)-DTBZ striatal uptake (Toyama et al, 2004; Chen et al, 2016). All of these results indicated anesthetization is one of the confounding factor to brain uptake.…”
Section: Discussionmentioning
confidence: 96%
“…Consequently, the reduction of DA uptake, which re ects the level of dopaminergic cell death, may occur at a lower rate than the loss of DA content and TH expression levels [42]. Additionally, the effects of anesthesia which were noticed attentively by researchers, may have in uenced the observed results [43,44]. Moreover, the partial volume effect and a bias parameter in vivo related to the intrinsic properties of the scanning device should be also taken into consideration, when interpreting the imaging data.…”
Section: Discussionmentioning
confidence: 99%
“…A major complication for translation in preclinical studies is the use of anesthetics. Anesthetics have effects not only in vasodilation or perfusion [239] but also on receptor binding in the brain [240][241][242]. Animal brain receptor experiments are often performed under anesthesia due to the difficulty or impossibility of training an animal to remain immobile during the scan.…”
Section: Quantitative Receptor Imaging In Clinical Translationmentioning
confidence: 99%