Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

Soares, Pedro Marcos Gomes; Lima, Ricardo; Pires, Alana de Freitas; Souza, Emmanuel Prata de; Assreuy, Ana Maria Sampaio; Criddle, David N.

doi:10.1016/j.lfs.2007.08.027

Cited by 59 publications

(45 citation statements)

References 19 publications

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“…The other major compounds are estragole (Zargari, 1989), eugenol (Monod and Dortan, 1950), methylchavicol, anisaldehyde (Wagner et al, 1984), terpene hydrocarbons (Kartnig et al, 1975), polyenes and polyacetylenes (Schulte et al, 1970). Among these compounds, it was reported that anethole at lower concentrations activates voltage-dependent Ca 2+ channels (Soares et al, 2007). There is considerable evidence available concerning the potential role of voltage dependent calcium channels in epileptogenesis (Jones, 2002).…”

Section: Discussionmentioning

confidence: 99%

The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization

Janahmadi

Farajnia

Vatanparast

et al. 2008

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization

Janahmadi

Farajnia

Vatanparast

et al. 2008

Journal of Ethnopharmacology

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“…Its pharmacological activities are reported to be anxiolytic (9), to induce contraction of skeletal muscle (10), and to relax ileal and other vascular smooth muscles (11,12). In addition to these activities, estragole has been shown to have an anti-inflammatory activity (13), which is pharmacologically potent (3-30 mg/kg per os ) and is effective at oral doses smaller than those considered toxic (LD 50 values of 1200 and 1800 mg/kg for rats and 1250 mg/kg for mice) (14).…”

Section: Introductionmentioning

confidence: 99%

Estragole blocks neuronal excitability by direct inhibition of Na+ channels

Silva‐Alves

Ferreira-da-Silva

Peixoto‐Neves

et al. 2013

Braz J Med Biol Res

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Estragole is a volatile terpenoid, which occurs naturally as a constituent of the essential oils of many plants. It has several pharmacological and biological activities. The objective of the present study was to investigate the mechanism of action of estragole on neuronal excitability. Intact and dissociated dorsal root ganglion neurons of rats were used to record action potential and Na+ currents with intracellular and patch-clamp techniques, respectively. Estragole blocked the generation of action potentials in cells with or without inflexions on their descendant (repolarization) phase (Ninf and N0 neurons, respectively) in a concentration-dependent manner. The resting potentials and input resistances of Ninf and N0 cells were not altered by estragole (2, 4, and 6 mM). Estragole also inhibited total Na+ current and tetrodotoxin-resistant Na+ current in a concentration-dependent manner (IC50 of 3.2 and 3.6 mM, respectively). Kinetic analysis of Na+ current in the presence of 4 mM estragole showed a statistically significant reduction of fast and slow inactivation time constants, indicating an acceleration of the inactivation process. These data demonstrate that estragole blocks neuronal excitability by direct inhibition of Na+ channel conductance activation. This action of estragole is likely to be relevant to the understanding of the mechanisms of several pharmacological effects of this substance.

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“…Fennel induced the relaxation of guinea pig tracheal chains via hyperpolarization, thus inhibiting calcium influx [19]. In addition, high doses of trans-anethole were reported to modify calcium channels on isolated rat aortas [20], further suggesting that the protective effect of fennel on TNF-α and ERK expression was due, at least in part, to calcium modulation.…”

Section: Discussionmentioning

confidence: 99%

Foeniculum vulgareMill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation

Lee

Kang

Kim

et al. 2015

Korean J Physiol Pharmacol

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Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflammatory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7~10). In five groups, the mice were intraperitoneally injected with 1% Tween 80-saline (vehicle), fennel (125, 250, 500µl/kg), or dexamethasone (1 mg/kg), followed 1 h later by intratracheal instillation of LPS (1.5 mg/kg). In two groups, the mice were intraperitoneally injected with vehicle or fennel (250µl/kg), followed 1 h later by intratracheal instillation of sterile saline. Mice were sacrificed 4 h later, and bronchoalveolar lavage fluid (BALF) and lung tissues were obtained. Fennel significantly and dose-dependently reduced LDH activity and immune cell numbers in LPS treated mice. In addition fennel effectively suppressed the LPS-induced increases in the production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, with 500µl/kg fennel showing maximal reduction. Fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (NO). Assessments of the involvement of the MAPK signaling pathway showed that fennel significantly decreased the LPS-induced phosphorylation of ERK. Fennel effectively blocked the inflammatory processes induced by LPS, by regulating pro-inflammatory cytokine production, transcription factors, and NO.

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Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels

Cited by 59 publications

References 19 publications

The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization

The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization

Estragole blocks neuronal excitability by direct inhibition of Na+ channels

Foeniculum vulgareMill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation

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