Effects of Angelica dahurica on obesity and fatty liver in mice

Lü, Xi; Yuan, Zhiyi; Yan, Xiaojin; Fan, Lei; Jiang, Jingfei; Yu, Xuan; Yang, Xiuwei; Xing, Dongming; Du, Lijun

doi:10.1016/s1875-5364(16)30076-0

Cited by 16 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 70% ethanol extract of A. dahurica root (800 mg/kg b. w., 4 weeks) significantly reduced the levels of TC and triglyceride (TG) in the livers of hyperlipidemia mice, as well as enhanced the activity of total hepatic lipolysis by upregulating the expression of PPARγ and lipid metabolism related genes-lipase member C (LIPC). Similarly, the levels of TC and TG were decreased by A. dahurica extract (400 μg/ml, 24 h) and IMP (20 μg/ml, 24 h) in 50% fetal bovine serum (FBS)-fed HepG2 cells (Lu et al, 2016). This study suggested the effect of A. dahurica root on the regulation of lipid metabolism and might be developed as a pharmaceutical product against fatty liver and hyperlipemia.…”

Section: Regulation Of Lipid Metabolismmentioning

confidence: 72%

“…Some of these bioactivities are consistent with the traditional uses of A. dahurica root, such as analgesic activity and effects on skin diseases. In addition, A. dahurica also exerts specific effects, related to anti-diabetic (Han et al, 2018), lowering blood lipids (Lu et al, 2016), improving immunity (Wang et al, 2021), anti-ulcer (Hu et al, 2021) and cosmetic effects (Cho et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Angelica dahurica (A. dahurica) root is a famous edible medicinal herb that has been used in China for thousands of years. To date, more than 300 chemical constituents have been discovered from A. dahurica. Among these ingredients, coumarins and volatile oils are the major active compounds. Moreover, a few other compounds have also been isolated from the root of A. dahurica, such as alkaloids, phenols, sterols, benzofurans, polyacetylenes and polysaccharides. Modern pharmacological studies demonstrated that the root of A. dahurica and its active components displayed various bioactivities such as anti-inflammation, anti-tumor, anti-oxidation, analgesic activity, antiviral and anti-microbial effects, effects on the cardiovascular system, neuroprotective function, hepatoprotective activity, effects on skin diseases and so on. Based on these studies, this review focused on the research publications of A. dahurica and aimed to summarize the advances in the traditional uses, phytochemistry and pharmacology which will provide reference for the further studies and applications of A. dahurica.

show abstract

Section: Regulation Of Lipid Metabolismmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Quantitative PCR (qPCR) was carried out as previously described [ 53 ]. All the primers used in these analyses were synthetized in Sangon Biotechnology Ltd. (Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

et al. 2023

Self Cite

View full text Add to dashboard Cite

p-coumaric acid (p-CA), a common plant phenolic acid with multiple bioactivities, has a lipid-lowering effect. As a dietary polyphenol, its low toxicity, with the advantages of prophylactic and long-term administration, makes it a potential drug for prophylaxis and the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanism by which it regulates lipid metabolism is still unclear. In this study, we studied the effect of p-CA on the down-regulation of accumulated lipids in vivo and in vitro. p-CA increased a number of lipase expressions, including hormone-sensitive lipase (HSL), monoacylglycerol lipase (MGL) and hepatic triglyceride lipase (HTGL), as well as the expression of genes related to fatty acid oxidation, including long-chain fatty acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyltransferase-1 (CPT1), by activating peroxisome proliferator-activated receptor α, and γ (PPARα and γ). Furthermore, p-CA promoted adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and enhanced the expression of the mammalian suppressor of Sec4 (MSS4), a critical protein that can inhibit lipid droplet growth. Thus, p-CA can decrease lipid accumulation and inhibit lipid droplet fusion, which are correlated with the enhancement of liver lipases and genes related to fatty acid oxidation as an activator of PPARs. Therefore, p-CA is capable of regulating lipid metabolism and is a potential therapeutic drug or health care product for hyperlipidemia and fatty liver.

show abstract

“…Angelica dahurica radix is a traditional medicinal ingredient that has been used in Korea and China for over a thousand years [15,16]. According to current pharmacological studies, A. dahurica's root has various biological activities, including anti-inflammatory [17], antioxidant [18], anticancer [19], antiviral [20] and hepatoprotective effects [21]. Moreover, numerous chemical compounds have been identified in A. dahurica, with coumarins and volatile oils reported as major active constituents [16].…”

Section: Introductionmentioning

confidence: 99%

Water Extract of Angelica dahurica Inhibits Osteoclast Differentiation and Bone Loss

Gu,

Yang,

Kim

et al. 2023

IJMS

View full text Add to dashboard Cite

Angelica dahurica radix has a long history of traditional use in China and Korea for treating headaches, cold-damp pain and skin diseases. Despite various pharmacological studies on A. dahurica, its impact on bones remains unclear. Hence, this study investigated the inhibitory effect of A. dahurica’s radix water extract (WEAD) on osteoclast differentiation. In vitro experiments showed that WEAD effectively suppresses osteoclast differentiation. Treatment of an osteoclast precursor with WEAD significantly suppressed the expression of nuclear factor of activated T-cells 1 (NFATc1), essential transcription factor for osteoclastogenesis, while increasing the expression of negative regulators, interferon regulatory factor 8 (Irf8) and v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MafB). Consistent with the in vitro findings, the oral administration of WEAD (100 and 300 mg/kg/day) to mice subjected to surgical ovariectomy for a duration of six weeks alleviated bone loss, while also mitigating weight gain and liver fat accumulation. In addition, we also identified phytochemicals present in WEAD, known to regulate osteoclastogenesis and/or bone loss. These results suggest the potential use of WEAD for treating various bone disorders caused by excessive bone resorption.

show abstract

Effects of Angelica dahurica on obesity and fatty liver in mice

Cited by 16 publications

References 48 publications

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

Water Extract of Angelica dahurica Inhibits Osteoclast Differentiation and Bone Loss

Contact Info

Product

Resources

About