Effects of Angiotensin Converting Enzyme Inhibitor and Calcium Antagonist on Endothelial Function in patients with Essential Hypertension.

On, Young-Keun; Kim, Cheol-Ho; Oh, Byung Hee; Lee, Hae Young; Park, Young-Bae

doi:10.1291/hypres.25.365

Cited by 54 publications

(28 citation statements)

References 30 publications

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“…The increase in superoxide anion generation could explain the decreased availability of basal NO observed in SHRSP (30). In contrast, treatment with an ACE inhibitor or a calcium antagonist resulted in demonstrable improvement of endothelial dysfunction by a mechanism that is probably related to antioxidant activity (32). Our findings in the endothelium as assessed by eNOS expression were similar for the two drugs, suggesting that both drugs might preserve NO to the same extent by increasing eNOS to attenuate vascular remodeling.…”

Section: Discussionmentioning

confidence: 53%

Calcium Antagonist Reduces Oxidative Stress by Upregulating Cu/Zn Superoxide Dismutase in Stroke-Prone Spontaneously Hypertensive Rats

et al. 2004

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Recent studies have suggested that the calcium antagonists have an antiatherogenic antioxidant property.The effects of the calcium antagonists on reactive oxygen species (ROS)-related enzymes, however, remain unknown. We hypothesized that the calcium antagonists inhibit oxidative stress in the hearts of strokeprone spontaneously hypertensive rats (SHRSP) through the ROS-scavenging enzymes known as superoxide dismutases (SODs). Male 12-week-old Wister-Kyoto rats (WKY) and SHRSP were used for the study.

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Section: Discussionmentioning

confidence: 53%

Calcium Antagonist Reduces Oxidative Stress by Upregulating Cu/Zn Superoxide Dismutase in Stroke-Prone Spontaneously Hypertensive Rats

et al. 2004

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“…Alternatively, IMT reflects structural changes in the wall of the internal carotid artery, although PWV reflects both structural changes in the artery wall and its functional flexibility. Recent studies reported that the functional improvement of arterial endothelium occurred initially after 2 months of treatment with amlodipine 30 and after 6 weeks of treatment with valsartan. 31 The decrease in PWV after 12 months of treatment with amlodipine and valsartan observed in the present study may reflect the improved endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients

et al. 2006

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The present study was performed to compare the longterm effects of 24-h ambulatory blood pressure (BP) control with amlodipine versus valsartan on vascular damage in untreated hypertensive patients. Amlodipine and valsartan have benefits on cardiovascular mortality and morbidity in hypertensive patients. Although ambulatory BP is associated with severity of target-organ damage in hypertensive patients, beneficial effects of ambulatory BP control with amlodipine versus valsartan on vascular damage have not been compared. Pulse wave velocity (PWV), intima-media thickness (IMT) of the carotid arteries, urinary albumin excretion (UAE) and 24-h ambulatory BP were determined in 100 untreated hypertensive patients before and 12 months after the start of antihypertensive therapy with amlodipine or valsartan. Amlodipine and valsartan decreased ambulatory BP similarly, but the variability of 24-h and daytime ambulatory systolic BP was significantly reduced by amlodipine but not by valsartan. The reduced variability of ambulatory systolic BP caused by amlodipine significantly contributed to the improvement of PWV, although both drugs decreased PWV similarly. Carotid IMT was unaffected by treatment with either drug. Valsartan significantly decreased UAE independently of its depressor effect, but amlodipine had no effect on UAE. These results suggest that the 24-h control of ambulatory BP with amlodipine had functionally improved the stiffened arteries of hypertensive patients by the end of 12 months of treatment, in part through reducing BP variability, whereas ambulatory BP control with valsartan decreased the arterial stiffness to the same degree as amlodipine without affecting BP variability maybe through some pleiotropic effects.

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“…[17][18][19] Antioxidants have been shown to restore endothelial function in patients with coronary artery disease. 20,21 It is known that statins and ACE inhibitors improve endothelial function; 22,23 therefore, they may influence the thioredoxin levels at admission and during hospital stay and follow-up. In the present study, there were no differences in medication between the success and failure groups.…”

Section: Discussionmentioning

confidence: 99%

Increased plasma thioredoxin in patients with acute myocardial infarction

Soejima

Suefuji

Miyamoto

et al. 2003

Clinical Cardiology

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SummaryBackground and hypothesis: Thioredoxin is an important biomarker for oxidative stress. We investigated whether thioredoxin levels were elevated in patients with acute myocardial infarction (AMI) and were associated with the results of coronary reperfusion.Methods: The present study determined plasma thioredoxin levels in 51 patients with AMI, 30 patients with stable exertional angina (SEA), and 30 patients with chest pain syndrome (CPS). Plasma sampling was performed on admission, at 12 h, 1 week, 2 weeks, and 4 weeks in patients with AMI, and after admission in patients with SEA and CPS.Results: Plasma thioredoxin levels on admission were higher in patients with AMI than in those with SEA and CPS. Plasma thioredoxin levels in patients with AMI were decreased in 12 h without further change thereafter. However, thioredoxin levels in patients with AMI remained higher than in those with SEA. In multivariate analysis, higher levels of thioredoxin on admission were a risk factor for failure in emergent reperfusion therapy in patients with AMI independent of other factors.

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Effects of Angiotensin Converting Enzyme Inhibitor and Calcium Antagonist on Endothelial Function in patients with Essential Hypertension.

Cited by 54 publications

References 30 publications

Calcium Antagonist Reduces Oxidative Stress by Upregulating Cu/Zn Superoxide Dismutase in Stroke-Prone Spontaneously Hypertensive Rats

Calcium Antagonist Reduces Oxidative Stress by Upregulating Cu/Zn Superoxide Dismutase in Stroke-Prone Spontaneously Hypertensive Rats

Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients

Increased plasma thioredoxin in patients with acute myocardial infarction

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