Effects of angiotensin I of the american bullfrog Rana catesbeiana on amphibian tissues

Coviello, Alfredo; Soria, Marcelo O.; Proto, Maria; Bruno, María Peral de; Berman, Dora M.; Khosla, M. C.; Bumpus, F. M.

doi:10.1016/0300-9629(93)90017-x

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…The vasodilator effect was observed in a dose-dependent manner, where the lowest pressure was observed at 1 μg/mL, similar to the vasodilation induced by BK (10 μM) (Figure A). It has been reported that ANG I causes vasoconstriction in biological systems in perfusion − and is blocked by ACE inhibitors; ,− then ANG I and ANG II (1 μM) were tested as vasoconstriction controls, and CPT (50 μM) was used as vasodilation control and blocker of ACE (Figure B). In Figure C canary seed peptides (1 μg/mL) were used instead of CPT.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Antidiabetic and Antihypertensive Properties of Canary Seed (Phalaris canariensis L.) Peptides

Estrada-Salas

Montero-Morán

Martinez-Cuevas

et al. 2014

J. Agric. Food Chem.

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Canary grass is used as traditional food for diabetes and hypertension treatment. The aim of this work is to characterize the biological activity of encrypted peptides released after gastrointestinal digestion of canary seed proteins. Canary peptides showed 43.5% inhibition of dipeptidyl peptidase IV (DPPIV) and 73.5% inhibition of angiotensin-converting enzyme (ACE) activity. An isolated perfused rat heart system was used to evaluate the canary seed vasoactive effect. Nitric oxide (NO), a major vasodilator agent, was evaluated in the venous effluent from isolated perfused rat heart. Canary seed peptides (1 μg/mL) were able to induce the production of NO (12.24 μM) in amounts similar to those induced by captopril (CPT) and bradykinin (BK). These results show that encrypted peptides in canary seed have inhibitory activity against DPPIV and ACE, enzymes that are targets for diabetes and hypertension treatments.

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