Effects of Angiotensin II Receptor Antagonists on Insulin Resistance Syndrome and Leptin in Sucrose-Fed Spontaneously Hypertensive Rats.

Umeda, Mamoru; Kanda, Tsugiyasu; Murakami, Masami

doi:10.1291/hypres.26.485

Cited by 41 publications

(37 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ARBs ameliorates insulin resistance and hyperleptinemia in sucrose-fed, spontaneously hypertensive rats [23]. Similarly, irbesartan was reported to improve insulin sensitivity in obese Zucker rats with severe insulin resistance [24].…”

Section: Discussionmentioning

confidence: 98%

Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Kim

Choi

2010

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Kim

Choi

2010

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

“…Insulin resistance was assessed by the homeostasis model assessment-insulin resistance (HOMA-IR) index (Matthews et al 1985), which was calculated as [fasting blood glucose (mg/dl) fasting insulin (mg/ml)]/405 (Umeda et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…The time required to attenuate basal glucose levels by 50% was 60 min in control pttg The HOMA-IR (Homeostasis Model Assessment) index (Matthews et al 1985, Umeda et al 2003, a physiologic marker for insulin resistance, was calculated for each group of animals at 2 month intervals starting at the age of 2 months. A higher HOMA index score is an estimated reflection of increased insulin resistance.…”

Section: Gonadectomy With or Without Additional Estradiol Therapy Faimentioning

confidence: 99%

Sex-steroid milieu determines diabetes rescue in pttg-null mice

Fraenkel

Caloyeras²,

Ren

et al. 2006

Journal of Endocrinology

View full text Add to dashboard Cite

Male mice that are pttg-null develop sexually dimorphic diabetes with hypoinsulinemia secondary to reduced postnatal -cell proliferation and an inability to expand islet cell mass with aging. We therefore examined the effects of sex-steroid manipulation on diabetes development in pttg / male mice. Surgical gonadectomy was followed by implantation of 90-day slow-release pellets releasing 17 -estradiol (0·36 mg/pellet), placebo or dihydrotestosterone (DHT; 12·5 mg/pellet). Mean fasting blood sugars at the end of the study were 414 54 mg/dl for pttg . Gonadectomy with and without estradiol treatment did not increase the very low circulating insulin levels in pttg-null males (fasting insulin 0·44 0·04 ng/ml in pttg / controls, 0·47 0·07 and 0·4 ng/ml in pttg / gonadectomized males treated with placebo or estradiol, respectively). Gonadectomy increased serum adiponectin levels (4·9 008 µg/ml in pttg / controls versus 13 0·08 and 7·5 0·6 µg/ml in pttg / gonadectomized males treated with placebo or estradiol, respectively; P<0·001 and P<0·05), accompanied by increased insulin sensitivity. The results show that gonadectomy delayed, and gonadectomy with additional estradiol treatment prevented, diabetes development in pttg / males, possibly through increased insulin sensitivity mediated by elevated serum adiponectin levels. Male-selective effects of disrupted -cell proliferation in the absence of pttg are restored by sex-steroid effects on peripheral insulin sensitivity.

show abstract

“…However, ACEI increases bradykinin concentration, a process that might be more closely associated with insulin sensitivity (13) that ACEI (temocapil) and ARB (olmesartan) both improved insulin resistance in fructose-fed rats. Recently, Umeda et al (19) reported that ARB ameliorated insulin resistance and hyperleptinemia in sucrose-fed spontaneously hypertensive rats. Similarly, we found that olmesartan significantly ameliorated insulin sensitivity in fructose-fed rats as determined by Bergman's minimal model.…”

Section: Discussionmentioning

confidence: 99%

Olmesartan Medoxomil, an Angiotensin II Receptor Blocker Ameliorates Insulin Resistance and Decreases Triglyceride Production in Fructose-Fed Rats

et al. 2004

View full text Add to dashboard Cite

Effects of Angiotensin II Receptor Antagonists on Insulin Resistance Syndrome and Leptin in Sucrose-Fed Spontaneously Hypertensive Rats.

Cited by 41 publications

References 42 publications

Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Sex-steroid milieu determines diabetes rescue in pttg-null mice

Olmesartan Medoxomil, an Angiotensin II Receptor Blocker Ameliorates Insulin Resistance and Decreases Triglyceride Production in Fructose-Fed Rats

Contact Info

Product

Resources

About