Effects of angiotensin type 2 receptor on secretion of the locus coeruleus in stress-induced hypertension rats

Gong, W.; Lü, Jun; Feng, Weiyue; Wang, Bin; Wang, Mengya; Huang, HJ

doi:10.1016/j.brainresbull.2014.12.011

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…However, little is known about how AT2 receptors influence the activity of LC neurons in vivo . Recent work has demonstrated that intracerebroventricular injection of the AT2 receptor agonist CGP42112 decreases the hypothalamic NA release triggered by electrical stimulation of the LC , but the underlying mechanisms have not been investigated. A series of in vitro studies have established that hypothalamic and brainstem noradrenergic neurons isolated from newborn rats coexpress AT1 and AT2 angiotensin receptor subtypes in vitro , both of which are activated following treatment with Ang‐II .…”

Section: Discussionmentioning

confidence: 99%

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen

et al. 2016

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“…Amperometric detection of NE signals with carbon fiber electrode was performed according to our previously described method (Gong et al, 2015). Rats were anesthetized with pentobarbital (50 mg/kg, i.p.…”

Section: Methodsmentioning

confidence: 99%

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression

Wang

et al. 2017

Front. Neurosci.

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Chronic stressors can often lead to the development of psychological disorders, such as depression and anxiety. The locus coeruleus (LC) is a stress sensitive brain region located in the pons, with noradrenergic neurons that project to the hypothalamus, especially the paraventricular nucleus (PVN) of the hypothalamus. The purpose of this paper is to better understand how alpha 2A-adrenoceptors (α2A-ARs) and LC-hypothalamus noradrenergic system participate in the pathophysiological mechanism of depression. In vivo norepinephrine (NE) release in the PVN triggered by electrical stimulation in the LC was detected with carbon fiber electrodes in depression model of rats induced by chronic unpredictable mild stress (CUMS). Also, the extracellular level of NE in the PVN was measured by microdialysis in vivo without any stimulation in the LC. The alpha 2-adrenoceptor (α2-AR) antagonist yohimbine and α2A-ARs antagonist BRL-44408 maleate were systemically administered to rats to determine the effects of α2A-ARs on NE release in the PVN. The peak value of elicited NE release signals in the PVN induced by electrical stimulation in the LC in the CUMS rats were lower than that in the control rats. The extracellular levels of NE in the PVN of the CUMS rats were significantly less than that of the control rats. Intraperitoneal injection of yohimbine or BRL-44408 maleate significantly potentiated NE release in the PVN of the CUMS rats. The CUMS significantly increased protein expression levels of α2A-AR in the hypothalamus, and BRL-44408 maleate significantly reversed the increase of α2A-AR protein expression levels in the CUMS rats. Our results suggest that the CUMS could significantly facilitate the effect of α2-adrenoceptor-mediated presynaptic inhibition and decrease the release of NE in the PVN from LC. Blockade of the inhibitory action of excessive α2A-adrenergic receptors in the CUMS rats could increase the level of NE in the PVN, which is effective in the treatment of depressive disorders.

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“…The LC is the preeminent noradrenergic nucleus and source of norepinephrine in the brain. Among various other functions, the LC mediates the autonomic response to stressful stimuli [11]. …”

Section: Overview Of the Central Control Of Blood Pressure And Effectmentioning

confidence: 99%

“…The mechanisms by which AT2R stimulation attenuates sympathetic outflow are only partly understood, but seem to be multimodal and involve a decrease in norepinephrine secretion from the locus coeruleus to the hypothalamus [11], stimulatory effects on neuronal potassium current resulting in hyperpolarization and reduced firing rates [39,40], and an intact central NO pathway [24]. …”

Section: At2r and The Regulation Of Sympathetic Outflowmentioning

confidence: 99%

Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor

Steckelings

Kloet

Sumners

2017

Trends in Endocrinology & Metabolism

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Sustained increases in activity of the sympathetic neural pathways that exit the brain and which increase blood pressure are a major underlying factor in resistant hypertension. Recently available information on the occurrence of angiotensin II type 2 receptors (AT2R) within or adjacent to brain cardiovascular control centers is consistent with findings that stimulation of these receptors lowers blood pressure, particularly during hypertension of neurogenic origin. Up until recently, brain AT2R had not been considered by many to play a role in the central control of blood pressure. Demonstration of these powerful anti-hypertensive effects of brain AT2R opens the door to reconsideration of their role in blood pressure regulation, and their consideration as a novel therapeutic avenue for resistant hypertension.

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Effects of angiotensin type 2 receptor on secretion of the locus coeruleus in stress-induced hypertension rats

Cited by 14 publications

References 23 publications

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen

Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression

Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor

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