Effects of Anterior Pituitary Adenomas’ Hormones on Glucose Metabolism and Its Clinical Implications

Li, Mengnan; Zhang, Jian; Yang, Guimei; Zhang, Jiaxin; Han, Min; Zhang, Yi; Liu, Yunfeng

doi:10.2147/dmso.s397445

Cited by 7 publications

(2 citation statements)

References 165 publications

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“…High prolactin levels have been shown to directly reduce adiponectin levels in cell and animal model studies. This reduction in adiponectin leads to decreased insulin-mediated inhibition of hepatic gluconeogenesis, resulting in lower glucose uptake and reduced fatty acid oxidation by fat and muscle cells (18,56).…”

Section: Discussionmentioning

confidence: 99%

Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center

Hofbauer,

Horka,

Seidenberg

et al. 2024

Front. Endocrinol.

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BackgroundProlactinomas (PRLs) are prevalent pituitary adenomas associated with metabolic changes and increased cardiovascular morbidity. This study examined clinical, endocrine, metabolic, and inflammatory profiles in PRL patients, aiming to identify potential prognostic markers.MethodsThe study comprised data from 59 PRL patients gathered in a registry at the University Hospital of Zurich. Diagnostic criteria included MRI findings and elevated serum prolactin levels. We assessed baseline and follow-up clinical demographics, metabolic markers, serum inflammation-based scores, and endocrine parameters. Treatment outcomes were evaluated based on prolactin normalization, tumor shrinkage, and cabergoline dosage.ResultsThe PRL cohort exhibited a higher prevalence of overweight/obesity, prediabetes/diabetes mellitus, and dyslipidemia compared to the general population. Significant correlations were found between PRL characteristics and BMI, HbA1c, and fT4 levels. Follow-up data indicated decreases in tumor size, tumor volume, prolactin levels, and LDL-cholesterol, alongside increases in fT4 and sex hormones levels. No significant associations were observed between baseline parameters and tumor shrinkage at follow-up. A positive association was noted between PRL size/volume and the time to achieve prolactin normalization, and a negative association with baseline fT4 levels.ConclusionThis study underscores the metabolic significance of PRL, with notable correlations between PRL parameters and metabolic indices. However, inflammatory markers were not significantly correlated with patient stratification or outcome prediction. These findings highlight the necessity for standardized follow-up protocols and further research into the metabolic pathogenesis in PRL patients.

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Section: Discussionmentioning

confidence: 99%

Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center

Hofbauer,

Horka,

Seidenberg

et al. 2024

Front. Endocrinol.

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“…A meta-analysis has uncovered that drug-naïve patients experiencing a first episode of psychosis (FEP) exhibit elevated blood concentrations of adrenocorticotropic hormone (ACTH) and prolactin (PRL), along with lower levels of thyroid-stimulating hormone (TSH) [67]. These anterior pituitary hormones play a crucial role in energy metabolism and weight regulation [68]. Moreover, genome-wide association studies (GWAS) have revealed potential shared genetic variations or pathways between schizophrenia and metabolic abnormalities [69].…”

Section: Discussionmentioning

confidence: 99%

The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China

Ma,

Zhou,

et al. 2024

Brain Sciences

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Patients with schizophrenia often encounter notable weight gain during their illness, heightening the risk of metabolic diseases. While previous studies have noted a correlation between obesity and cognitive impairment in schizophrenia, many were cross-sectional, posing challenges in establishing a causal relationship between weight gain and cognitive function. The aim of this longitudinal study is to examine the relationship between weight gain and cognitive function in patients with first-episode schizophrenia (FES) during the initial 6-month antipsychotic treatments. Employing linear and logistic regression analyses, the study involved 337 participants. Significantly, baseline scores in processing speed (OR = 0.834, p = 0.007), working memory and attention (OR = 0.889, p = 0.043), and executive function (OR = 0.862, p = 0.006) were associated with clinically relevant weight gain (CRW, defined as an increase in body weight > 7%) at the 6-month endpoint. On the other hand, CRW correlated with improvements in the Brief Visuospatial Memory Test (p = 0.037). These findings suggest that patients with lower baseline cognitive performance undergo more substantial weight gain. Conversely, weight gain was correlated with cognitive improvements, particularly in the domain of visual learning and memory. This suggested a potential bidirectional relationship between weight gain and cognitive function in first-episode schizophrenia patients.

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Early Surgical Intervention in Nonfunctioning Pituitary Macroadenomas in Adult Patients without Optic Apparatus Compression—Should We Consider It? A Matched Case-Control Study

Sufaro,

Shmueli,

Avraham

et al. 2024

World Neurosurgery

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Effects of Anterior Pituitary Adenomas’ Hormones on Glucose Metabolism and Its Clinical Implications

Cited by 7 publications

References 165 publications

Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center

Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center

The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China

Early Surgical Intervention in Nonfunctioning Pituitary Macroadenomas in Adult Patients without Optic Apparatus Compression—Should We Consider It? A Matched Case-Control Study

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