Effects of anthocyanin extracted from black soybean seed coat on spermatogenesis in a rat varicocele-induced model

Jang, Han Ik; Kim, Su Jin; Yuk, Seung Mo; Han, Dong Seok; Ha, U-Syn; Hong, Sung Hoo; Lee, Ji Yeol; Hwang, Tae‐Kon; Hwang, Soo Hyun; Kim, Sae Woong

doi:10.1071/rd11174

Cited by 24 publications

(20 citation statements)

References 34 publications

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“…These changes were similar to those observed in varicocoele patients, which leads to infertility associated with the impaired testicular drainage system and persistent testicular hypoxia in the sperm production site (Gat et al ., ). Apoptotic processes occur in the mammalian testis during development as well as in adulthood (Giampietri et al ., ), and these processes are known to play an important role in regulating spermatogenesis (Ku et al ., ; Jang et al ., ; Ward, ). In this study, we studied germ cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of testicular‐internal spermatic vein variation and the recreation of varicocoele in a Sprague‐Dawley rat model

et al. 2014

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SUMMARYMany laboratories tried to recreate the varicocoele model have met with varied success. To recreate a consistent varicocoele model by exploring the anatomic variability of the testicular-spermatic venous system in Sprague-Dawley (SD) rats. Seventy-two sexually mature SD male rats were randomly divided into three groups containing 24 rats per group. Partial ligation of the left renal vein and internal spermatic vein (ISV) communicating branches to common iliac vein and ISV communicating branches ligation (RVISVCB-CIV) or partial ligation of the left renal vein and ISV communicating branches ligation (RVISVCB). The results showed that the mean diameter of the left ISV was significantly increased in the RVISVCBCIV group compared with the control and RVISVCB groups (p < 0.001). Using ISV as the reference, the sensitivity of varicocoele was 71.43%, and the specificity was 80%. In addition, the positive predictive value was 83.33%, and the negative predictive value was 66.67%. Sperm count, motility, Johnsen score and the spermatogenic cell density were lower in the RVISVCBCIV group compared with the control (p < 0.01). The apoptotic index was higher in the RVISVCBCIV group compared with control groups (p < 0.01). The RVISVCBCIV provides a more effective method for establishing a varicocoele-induced model.

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Section: Discussionmentioning

confidence: 99%

Analysis of testicular‐internal spermatic vein variation and the recreation of varicocoele in a Sprague‐Dawley rat model

et al. 2014

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“…Studies show that dolphinidine in this plant improves spermatogenesis and damage to testicular tissue in the varicocele model in rats. This compound improves sperm parameters (number and motility) and reduces apoptosis of spermatogonial cells (Jang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…This compound improves sperm parameters (number and motility) and reduces apoptosis of spermatogonial cells (Jang et al, 2012).…”

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confidence: 99%

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

et al. 2020

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Anabolic androgenic steroids (AAS) such as oxymetholone (OM) used for athletic enhancement, but increased free radicals damage and changes in hormonal levels, lead to serious and irreversible organ damage. Vaccinium arctostaphylos(V. arctostaphylos( has been demonstrated to have antioxidant and antiinflammatory effects. The aim of present study was to investigate V. arctostaphylos effect on OM‐induced oxidative injury in mouse testis and sperm parameters. In this experimental study, 30 BALB/c mice were divided into five groups, including healthy, positive control(5 mg/kg OM) and three treatment groups (100, 200 and 400 mg/kg of V. arctostaphylos extract + 5 mg/kg OM). At the end of the study, serum luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and testosterone levels were measured. Testis stereological and sperm parameters were calculated. Antioxidant status was measured using nitric oxide (NO) and FRAP assay, and malondialdehyde (MDA) levels. Furthermore, the expression of p53, caspase‐3, Bax and Bcl‐2 was measured. V. arctostaphylos decreased the serum level of testosterone, increased the LH and FSH, and improved the stereological and sperm parameters and down‐regulated the p53, caspase‐3 and Bax and up‐regulated Bcl‐2 genes. Furthermore, this dose decreased serum levels of NO and increased testis FRAP and MDA levels in treated groups compared with OM group. V. arctostaphylos extract has protective effects against testicular toxicity caused by OM.

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“…8-OHdG is an established indicator of DNA oxidative stress [25]. In this study, the 8-OHdG level was lower in the rats that underwent bariatric surgery, indicating that bariatric surgery decreases oxidative stress associated with T2DM in the penile corpus cavernosum.…”

Section: Discussionmentioning

confidence: 46%

Bariatric Surgery Improves the Cavernosal Neuronal, Vasorelaxation, and Contraction Mechanisms for Erectile Dysfunction As Result of Amelioration of Glucose Homeostasis in a Diabetic Rat Model

et al. 2014

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BackgroundBariatric surgery is an effective treatment option for both obesity and obesity-related type 2 diabetes mellitus (T2DM). However, little is known regarding the effects of bariatric surgery on erectile dysfunction among patients with T2DM. Therefore, we investigated whether bariatric surgery would lead to structural and biochemical changes in the corpus cavernosum.Material and MethodTwenty-five male Otsuka Long-Evans Tokushima Fatty rats were assigned to either a control group (sham operation, n = 10) or a bariatric surgery group (gastric bypass surgery, n = 15). Four weeks after the operation, each group of rats was evaluated with an oral glucose tolerance test (OGTT). The penile intracavernous pressure was measured for erectile functional analysis. Histologic evaluation of the tissue was performed with Masson's trichrome staining. Endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), Rho kinase, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in the corpus cavernosum were assayed by using western blot and ELISA.ResultsThe mean body weight of the bariatric surgery group was lower than the control group (p = 0.002). The postoperative OGTT result was lower in the bariatric surgery group than in the control group (p = 0.014), and this was lower than the preoperative value (p = 0.037). The intracavernous pressure/mean arterial pressure ratio was higher in the bariatric surgery group compared to the control group (p = 0.021), and a higher cavernosum smooth muscle/collagen ratio was observed in the bariatric surgery group compared to the control group (p = 0.025). Likewise, the expression of eNOS and nNOS was higher in bariatric surgery group than in the control group (p = 0.027 and p = 0.008, respectively). Decreased expression of Rho kinase and levels of 8-OHdG were observed in the bariatric surgery group (p = 0.032).ConclusionIn this animal model, bariatric surgery appears to ameliorate T2DM-related metabolic dysfunction leading to structural and biochemical changes in the corpus cavernosum, and thus, results in improvement of erectile dysfunction associated with T2DM.

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Effects of anthocyanin extracted from black soybean seed coat on spermatogenesis in a rat varicocele-induced model

Cited by 24 publications

References 34 publications

Analysis of testicular‐internal spermatic vein variation and the recreation of varicocoele in a Sprague‐Dawley rat model

Analysis of testicular‐internal spermatic vein variation and the recreation of varicocoele in a Sprague‐Dawley rat model

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

Bariatric Surgery Improves the Cavernosal Neuronal, Vasorelaxation, and Contraction Mechanisms for Erectile Dysfunction As Result of Amelioration of Glucose Homeostasis in a Diabetic Rat Model

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