Effects of Anthocyanins on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang, Liping; Liu, Wenhua; Du, Zhicheng; Chen, YuMing; Li, Dan; Deng, Shizhou; Liu, Zhaomin

doi:10.3945/an.116.014852

Cited by 136 publications

(114 citation statements)

References 72 publications

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“…We additionally found that the berries but not the grapes/wine significantly reduced T-C and increased FMD. In agreement with this last result, a recent meta-analysis on 24 RCTs showed that both acute and chronic supplementation with ANC-rich foods or extracts significantly improved FMD and improved wave velocity after acute consumption [21]. …”

Section: Discussionsupporting

confidence: 60%

“…Previous reviews and meta-analyses of randomized-controlled trials (RCTs) have explored the evidence of the effects of the intake of berry [16,17,18,19,20,21], nut [22,23], pomegranate [24,25], and grape [26,27] foods and (or) derived products on different cardiometabolic risk factors (i.e., serum lipids, blood pressure, glucose). The results of these analyses have indicated inconsistencies in the overall effects and have pointed at potential different responses between different subpopulations.…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

119

107

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Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

119

107

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“…With this objective, a number of recent studies have discussed the interest of including fruits in the human diet, as sources of bioactive phytochemicals, more specifically anthocyanins. Along this line, this strategy is supported by the cumulative data available on the biological effects of these compounds on glycolipid metabolism, reducing fasting and 2 h postprandial glucose, and modulating the level of glycemic biomarkers and low density lipoprotein (LDL) [10,11]. However, the bioavailability of the bioactive polyphenols reported in the literature is low, being estimated to lie in a range between 5% and 10% of the total intake, after intestinal absorption [12].…”

Section: Introductionmentioning

confidence: 97%

Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages

et al. 2020

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Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases.

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“…The dietary intake of ACNs is up to 9-fold higher than that of other dietary flavonoids. Epidemiological studies have found an inverse association between the consumption of ACNs and risk of cardiovascular diseases [1][2][3][4][5][6]. Their role in prevention of cardiovascular disease is strongly linked to the protection against oxidative stress and inflammation [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Anthocyanins and metabolites resolve TNF-α-mediated production of E-selectin and adhesion of monocytes to endothelial cells

Bò

Marino

Riso

et al. 2019

Chemico-Biological Interactions

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This study investigated the capacity of an anthocyanin-rich fraction (ACN-RF) from blueberry, single anthocyanins (cyanidin, delphinidin and malvidin-3-glucoside; Cy, Dp and Mv-3-glc) and related metabolites (protocatechuic, gallic and syringic acid; PrA, GA and SA) to resolve an inflammationdriven adhesion of monocytes (THP-1) on endothelial cell (HUVECs) and secretion of cell adhesion molecules E-selectin and vascular cell adhesion molecule 1 (VCAM-1). The adhesion of THP-1 to HUVECs was induced by tumour necrosis factor α (TNF-α, 100 ng mL-1). Subsequently, ACN-RF, single ACNs and metabolites (from 0.01 to 10 μg mL-1) were incubated for 24 h. The adhesion was measured in a fluorescence spectrophotometer. E-selectin and VCAM-1 were quantified by ELISA. No toxicological effects were observed for the compounds and the doses tested. ACN-RF and Mv-3-glc reducedTHP-1 adhesion at all the concentrations with the maximum effect at 10 μg/ml (-60.2% for ACNs and-33.9% for Mv-3-glc). Cy-3-glc decreased the adhesion by about 41.8% at 10 μg mL-1 , while PrA and GA reduced the adhesion of THP-1 to HUVECs both at 1 and at 10 μg mL-1 (-29.5% and-44.3% for PrA, respectively, and-18.0%and-59.3% for GA, respectively). At the same concentrations a significant reduction of E-selectin, but notVCAM-1 levels, was documented. No effect was observed following Dp-3-glc and SA supplementation. Overall, ACNs and metabolites seem to resolve, in a dose-dependent manner, the inflammationdriven adhesion of THP-1 to HUVECs by decreasing E-selectin concentrations. Interestingly, Mv-3glc was active at physiologically relevant concentrations.

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Effects of Anthocyanins on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 136 publications

References 72 publications

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages

Anthocyanins and metabolites resolve TNF-α-mediated production of E-selectin and adhesion of monocytes to endothelial cells

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