Effects of antibiotic dry-cow therapy and internal teat sealant on milk somatic cell counts and clinical and subclinical mastitis in early lactation

Golder, H.M.; Hodge, Allison; Lean, I.J.

doi:10.3168/jds.2016-11114

Cited by 33 publications

(30 citation statements)

References 24 publications

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“…Most studies that have investigated the use of antibiotic treatment at drying off are limited to early (Golder et al, 2016) or mid subsequent lactation (Sampimon et al, 2009;Bradley et al, 2010;Cameron et al, 2014;Wittek et al, 2018) only. Yet results from this study show that cows treated with antibiotic plus teat seal- Figure 2.…”

Section: Using Teat Sealant Alone To Control Sccmentioning

confidence: 99%

Effect of using internal teat sealant with or without antibiotic therapy at dry-off on subsequent somatic cell count and milk production

McParland

Dillon

Flynn

et al. 2019

Journal of Dairy Science

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The objective of this study was to assess the effect of treating cows with teat sealant only compared with antibiotic plus teat sealant at drying off on weekly somatic cell count, potential intramammary infection, and milk production across the entire subsequent lactation. In 3 research herds in the south of Ireland, cows with SCC that did not exceed 200,000 cells/mL in the previous lactation (LowSCC) were randomly assigned to 1 of 2 treatments at drying off: internal teat sealant alone (ITS) or antibiotic plus teat sealant (AB+ITS). Cows with SCC that exceeded 200,000 cells/mL in the previous lactation were treated with AB+ITS and included in the analyses as a separate group (HighSCC). Weekly individual animal composite SCC records were available for 654 cow lactations and were transformed to somatic cell scores (SCS) for the purpose of analysis. Data were divided into 3 data sets to represent records obtained (1) up to 35 DIM, (2) up to 120 DIM, and (3) across the lactation. Foremilk secretions were taken from all quarters at drying off, at calving, 2 wk after calving, and in mid-lactation and were cultured to detect the presence of bacteria. The LowSCC cows treated with ITS alone had higher daily milk yield (0.67 kg/d) across lactation compared with LowSCC cows treated with AB+ITS. The LowSCC cows treated with ITS alone had higher SCS in early, up to mid, and across lactation compared with LowSCC cows treated with AB+ITS. We detected no difference in weekly SCS of LowSCC cows treated with ITS alone and SCS of HighSCC cows. The least squares means back-transformed SCC across lactation of the LowSCC cows treated with ITS alone, LowSCC cows treated with AB+ITS, and HighSCC cows were 41,523, 34,001, and 38,939 cells/mL respectively. The odds of LowSCC cows treated with ITS alone having bacteria present in their foremilk across lactation was 2.7 (95% confidence interval: 1.91 to 3.85) and 1.6 (1.22 to 2.03) times the odds of LowSCC cows treated with AB+ITS and of HighSCC cows treated with AB+ITS, respectively. In this study, Staphylococcus aureus was the most prevalent pathogen isolated from the population. Recategorizing the threshold for LowSCC cows as ≤150,000 cells/mL or ≤100,000 cells/mL in the previous lactation had no effect on the results. The results indicate that herds with good mastitis control programs may use ITS alone at dry-off in cows with SCC <200,000 cells/mL across lactation with only a small effect on herd SCC.

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Section: Using Teat Sealant Alone To Control Sccmentioning

confidence: 99%

Effect of using internal teat sealant with or without antibiotic therapy at dry-off on subsequent somatic cell count and milk production

McParland

Dillon

Flynn

et al. 2019

Journal of Dairy Science

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“…Mastitis is a complex and widespread disease with multiple microorganisms’ etiology and conditioned by several factors, added to the specificity of treatment to each of the agents, it becomes even more difficult to treat, requiring studies that evaluate the best treatment in the period of drying, to perform the selective treatment in dairy cows (STDC) (10,11) .…”

Section: Introductionmentioning

confidence: 99%

Rational Decision On the Use of Antibiotics During the Dry Period in Dairy Cows

Lopes

Lima

2019

Preprint

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The aim of this study was to evaluate the use of antibiotics in cows during the dry period. The survey was performed on 148 teats during the dry period, with sample collection in the period D-70 (70 days before delivery) and D14 (14 days after delivery). The milk samples were collected for the Strip Cup Test (SCT), California Mastitis Test (CMT), Microbiological Culture, Somatic Cell Count (SCC), Somatic Cell Score (SCS) and Hyperkeratosis (HK). The groups in which there were no microorganisms grow were divided into two groups, in the first group only the internal sealant in the teat was used (Group 1) and there was another group with the intramammary antibiotic use associated with the internal sealant (Group 2). Teats which were considered positive, with microbiological growth, were treated with the intramammary antibiotic associated with the internal sealant (Group 3). In the comparison of the results of the CMT test between D-70 and D14, a statistical difference was observed in Groups 2 and 3. Group 3, which comprises the positive teats in D-70 presented a reduction of 83.87% and 32.26% in the CMT test between D-70 and D14. Regarding HK, group 1 and 2 had a statistical difference in relation to group 3 in D-70 and D14. As for the numbers of bacteria isolated in D-70 and D14, there was no difference comparing Group 1 and Group 2, unlike Group 3, which had a difference. Group 1 and Group 2 were all negative teats in D-70, showing that the intramammary antibiotic did not influence the outcome of D14. In group 3 there was a reduction of isolates from 62 to 15 in D14. The most prevalent microorganism was Streptococcus agalactiae with 43.37% of the total isolates, followed by Staphylococcus aureus (16.87%) and Corynebacterium spp. (13.25%) and Coagulase negative Staphylococcus (SCN) (10.84%). The selective treatment of teats in dry dairy cows has advantages over Blanket Dry Cow Therapy by reducing the indiscriminate use of antibiotics, avoiding bacterial resistance, ensuring better milk quality and greater food safety. Antibiotics should only be used for teats with subclinical mastitis, with the microbiological culture at the end of lactation performed by fourth individual mammary.

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“…Due to the changes in cows' mammary physiology, cows are susceptible to bacterial infection during their dry-off period, especially in the first week of dry-off and before calving. Over 24% of healthy udders were infected by Staphylococcus aureus and Streptococcus during dry-off, which increased the incidence of subclinical and clinical mastitis in the next early lactation period (O'Rourke 2005;Pinedo et al 2012;Golder et al 2016). Prevention and treatment with antibiotic intramammary infusion to all quarters of the cows at dry-off…”

mentioning

confidence: 99%

Elimination of ceftiofur hydrochloride residue in postpartum cows' milk after intramammary infusing at dry-off

Kang

Liu

Zhao

et al. 2018

Journal of Integrative Agriculture

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The purpose of this study was to investigate the residue elimination of ceftiofur hydrochloride in milk of postpartum cows after intramammary infusing at dry-off. An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/ MS) method was developed and validated to detect ceftiofur hydrochloride residue in milk. Through preprocessing, ceftiofur hydrochloride was derivatized into a more stable compound dedfuroyl ceftiofur acetamide (DCA) for further analysis. The linear range of DCA was 0.1 to 50 μg kg-1. Average recoveries of DCA were 82.52-105.86%. The intra-day and interday coefficients of variation (CV) were 2.95-9.82 and 6.41-7.43%, respectively. The limit of detection (LOD) and limit of quantitation (LOQ) scores were 0.05 and 0.1 μg kg-1 , respectively. These parameters showed this method was reliable and valid. Twelve cows were administrated 10 mL ceftiofur hydrochloride by intramammary infusion (corresponding to 500 mg ceftiofur) to each udder after the last milking before the dry-off period. Milk was collected from each udder of cow at 12, 24, 36, 48, 60 and 72 h after calving and was mixed for each time point and each cow, then subjected to UPLC-MS/MS analysis. The results showed, the DCA concentrations in all milk samples were less than LOQ and the maximum residue limit (MRL) 100 μg kg-1 , which suggested the withdrawal time of ceftiofur hydrochloride intramammary infusion used for preventing and curing mastitis in dry cows was 0 day. The study provided guidance for the clinical applications of ceftiofur hydrochloride intramammary infusion (dry cow).

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Effects of antibiotic dry-cow therapy and internal teat sealant on milk somatic cell counts and clinical and subclinical mastitis in early lactation

Cited by 33 publications

References 24 publications

Effect of using internal teat sealant with or without antibiotic therapy at dry-off on subsequent somatic cell count and milk production

Effect of using internal teat sealant with or without antibiotic therapy at dry-off on subsequent somatic cell count and milk production

Rational Decision On the Use of Antibiotics During the Dry Period in Dairy Cows

Elimination of ceftiofur hydrochloride residue in postpartum cows' milk after intramammary infusing at dry-off

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