Effects of antibiotics on the viability of and toxin production by <i>Clostridium botulinum</i>

Yutani, Masahiro; Matsumura, Tomohiro; Fujinaga, Yukako

doi:10.1111/1348-0421.12928

Cited by 2 publications

(3 citation statements)

References 31 publications

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“…Studies have shown that food isolates of C. difficile possess MDR to tetracyclines, macrolides, penems and fluoroquinolones [71]. C. botulinum is not currently treated with antibiotic therapy due to the potential for BoNT release post bacterial cell lysis [15]. The treatment for BoNT is an equine anti-BoNT antiserum; however, it is not suitable for infant patients and has a risk of anaphylaxis [15].…”

Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%

“…C. botulinum is not currently treated with antibiotic therapy due to the potential for BoNT release post bacterial cell lysis [15]. The treatment for BoNT is an equine anti-BoNT antiserum; however, it is not suitable for infant patients and has a risk of anaphylaxis [15]. Infant patients receive Botulism Immune Globulin Intravenous, BabyBIG, in the United States.…”

Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%

“…Alarmingly, sepsis resultant from C. perfringens infection has a mortality rate of 74% in certain patient cohorts [14]. C. botulinum results in infant and adult intestinal botulism after intestinal colonisation and production of the botulinum neurotoxin (BoNT) [15]. Clostridioides infection is also associated with frequent disease recurrence (<8 weeks post first occurrence or initial incidence of infection) with ca.…”

Section: Introductionmentioning

confidence: 99%

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Foodborne Clostridioides Species: Pathogenicity, Virulence and Biocontrol Options

Garvey

2023

Microorganisms

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Clostridioides species possess many virulence factors and alarming levels of muti-drug resistance which make them a significant risk to public health safety and a causative agent of livestock disease. Clostridioides result in serious systemic and gastrointestinal diseases such as myonecrosis, colitis, food poisoning and gastroenteritis. As foodborne pathogens, Clostridioides species are associated with significant incidences of morbidity and mortality where the application of broad-spectrum antibiotics predisposes patients to virulent Clostridioides colonisation. As part of the One Health approach, there is an urgent need to eliminate the use of antibiotics in food production to safeguard animals, humans and the environment. Alternative options are warranted to control foodborne pathogens at all stages of food production. Antimicrobial peptides and bacteriophages have demonstrated efficacy against Clostridioides species and may offer antimicrobial biocontrol options. The bacteriocin nisin, for example, has been implemented as a biopreservative for the control of Listeria, Staphylococcus and Clostridia species in food. Bacteriophage preparations have also gained recognition for the antibacterial action against highly virulent bacterial species including foodborne pathogens. Studies are warranted to mitigate the formulation and administration limitations associated with the application of such antimicrobials as biocontrol strategies. This review outlines foodborne Clostridioides species, their virulence factors, and potential biocontrol options for application in food production.

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Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%

Section: Antibiotic Treament Of Clostridioides Speciesmentioning

confidence: 99%