Effects of anticholinergic medication on memory in schizophrenia

Strauss, Milton E.; Reynolds, Karen S.; Jayaram, Geetha; Tune, Larry E.

doi:10.1016/0920-9964(90)90045-9

Cited by 117 publications

(63 citation statements)

References 9 publications

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“…In addition, the study included one patient with EOP and co-morbid mental or behavioral disorders due to the use of cannabinoids at follow-up and one EOS patient, who at follow-up was treated with anticholinergic medication, which may impair cognition [45]. Based on the clinical assessment of JRJ (the interviewer) and selfreported alcohol and drug use on selected SCAN 2.1 items [56] at the beginning of every test session, none were judged intoxicated at the time of neuropsychological testing.…”

Section: Assessment Of Intelligencementioning

confidence: 99%

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Jepsen

Fagerlund

Pagsberg

et al. 2009

Eur Child Adolesc Psychiatry

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Only few prospective longitudinal studies have assessed the course of intelligence deficits in early onset schizophrenia (EOS), and these have used different age appropriate versions of Wechsler Intelligence Scales and age appropriate norms. The post-psychotic development of intelligence in EOS has predominantly been characterized as relatively stable in these studies. However, comparisons of IQs from different test versions based on the different norms may not permit unequivocal interpretations. The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8). The same version of a Wechsler Intelligence Scale was administered at both baseline and follow-up assessments, and the same norms were used to derive IQs at baseline and followup. Significantly smaller change in mean full scale intelligence quotient (FSIQ) was found in diagnostically stable EOS patients compared with healthy controls during the follow-up period. However, no statistically significant difference in mean FSIQ change was observed between patients with EOS and patients with other non-affective psychoses, although this result must be interpreted with caution due to the small sample sizes. The results suggest abnormally slow acquisition of new intellectual information and skills in EOS patients during the first 5 years after full clinical presentation.

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Section: Assessment Of Intelligencementioning

confidence: 99%

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Jepsen

Fagerlund

Pagsberg

et al. 2009

Eur Child Adolesc Psychiatry

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“…In one small study, higher serum anticholinergic levels correlated with worsened recall but improved reaction time (Strauss et al, 1990). It is possible that improvements in reaction time represent an anti-parkinsonian effect as all patients in the study were taking antipsychotic medications.…”

Section: B Both Procholinergic and Anticholinergic Compounds May Amementioning

confidence: 99%

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman

Talmage

Role

2007

International Review of Neurobiology

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Central cholinergic signaling has long been associated with aspects of memory, motivation, and mood, each affected functions in neuropsychiatric disorders such as schizophrenia. In this chapter, we review evidence related to the core hypothesis that dysregulation of central cholinergic signaling contributes to the pathophysiology of schizophrenia. Although central cholinergic circuits are resistant to simplification-particularly when one tries to parse the contributions of various classes of cholinergic receptors to disease related phenomena-the potential role of ACh signaling in Schizophrenia pathophysiology deserves careful consideration for prospective therapeutics. The established role of cholinergic circuits in attentional tuning is considered along with recent work on how the patterning of cholinergic activity may modulate corticostriatal circuits affected in schizophrenia.

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“…When schizophrenic subjects are asked to recall a list of words after a short delay (i.e., shortterm verbal memory), with or without cues, a deficit is almost always observed (Calev et al, 1983;Heinrichs & Zakzanis, 1998;Stirling et al, 1997;Strauss et al, 1990). This is true of immediate and delayed-recall tasks for verbal material.…”

Section: Verbal Memory-verbal Memory Referred To As Word Memory Wasmentioning

confidence: 96%

Cognition and functional outcome among deaf and hearing people with schizophrenia

Horton

Silverstein²

2007

Schizophrenia Research

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Effects of anticholinergic medication on memory in schizophrenia

Cited by 117 publications

References 9 publications

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Cognition and functional outcome among deaf and hearing people with schizophrenia

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