Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats

Koshikawa, Fujino; Koshikawa, Noriaki; Stephenson, John

doi:10.1016/0014-2999(85)90138-4

Cited by 28 publications

(9 citation statements)

References 24 publications

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“…We previously reported significantly lower cortical [ 123 I]R91150 bindings ratios in recent MDMA users when compared with control subjects (Reneman et al 2000a). In rats, fenfluramine, a potent 5-HT releaser, has been found to cause reductions in 5-HT 2 receptors (Koshikawa et al 1985). These findings were attributed to high levels of synaptic 5-HT.…”

Section: Discussionmentioning

confidence: 99%

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

Reneman

Endert

Bruin

et al. 2002

Neuropsychopharmacology

135

112

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Section: Discussionmentioning

confidence: 99%

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

Reneman

Endert

Bruin

et al. 2002

Neuropsychopharmacology

135

112

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“…Previous studies suggest that while 5-HT-induced wet-dog shakes are inhibited in a dose-related manner by 5-HT2 receptor antagonists such as ketanserin and pirenpirone (Yap & Taylor, 1983;Koshikawa et al, 1985) and are produced by the systemic administration of the 5-HT2 receptor agonist * Li 1 -(2,5 -dimethyl -4 -iodophenyl) -2 -aminopropane (Heaton et al, 1988), the other components of the 5-HT-syndrome are largely mediated by 5-HT1-like receptors (Lucki et al, 1984;Goodwin & Green, 1985;Tricklebank et al, 1985;Kennett & Curzon, 1988). For this reason the presence of another 5-HT2 receptor-mediated behaviour, namely the back muscle contractions described in the present study, provides a very useful tool to investigate further the neuropharmacology of spinal 5-HT.…”

Section: Behaviours Produced By Intrathecal Cg 3509 Administrationmentioning

confidence: 99%

Involvement of 5‐HT₂ receptors in the behaviours produced by intrathecal administration of selected 5‐HT agonists and the TRH analogue (CG 3509) to rats

Fone

Johnson

Bennett

et al. 1989

British J Pharmacology

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1 The behavioural effects of the intrathecal injection of a thyrotrophin-releasing hormone (TRH) analogue L-orotyl-L-histidyl-prolineamide (CG 3509, 0.5 /g), the non-selective 5-HT, and 5-HT2 receptor agonist 5-methoxy-N,N'-dimethyltryptamine (5-MeODMT, 2-100pg) and the selective 5-HT2 receptor agonist 2,5-dimethoxy-a,4-dimethyl-benzene ethamine hydrochloride (DOM, 2-25 ug) were compared with the response of systemically administered 5-MeODMT (2 mg kg-1, i.p.) in rats, to establish whether the agonist-induced behaviours were mediated by bulbospinal 5-HT, or 5-HT2 receptors. 2 Intrathecal injection of 5-MeODMT or DOM produced dose-related back muscle contractions (a previously undocumented behaviour) and wet-dog shakes which were both markedly attenuated by ritanserin pretreatment (1 mg kg 1, i.p.) indicating the involvement of 5-HT2 receptors. In contrast, reciprocal forepaw treading, flat body posture and Straub-tail were evoked by 5-MeODMT but not by DOM indicating that these behaviours were not produced by 5-HT2 receptor activation alone. However, as ritanserin pretreatment reduced the reciprocal forepaw treading induced by intrathecal 5-MeODMT, this behaviour may be facilitated by 5-HT2 receptor activation.3 Intrathecal 5,7-dihydroxytryptamine (5,7-DHT, 2 x 150pg) treatment decreased thoraco-lumbar spinal cord 5-HT (-95%) and potentiated the back muscle contractions produced by intrathecal DOM injection without altering the wet-dog shake behaviour. None of the components of the 5-HT syndrome produced by 5-MeODMT (2mgkg-1, i.p.), with the exception of a small increase in wet-dog shakes, was significantly altered by intrathecal 5,7-DHT (which reduced thoraco-lumbar spinal cord 5-HT by 84%). Taken together these data suggest that the only 5-HT agonist-induced behaviour mediated by the activation of 5-HT2 receptors located postsynaptic to bulbospinal 5-hydroxytryptaminergic (5-HTergic) neurones was back muscle contractions. 4 The wet-dog shake and forepaw licking behaviors produced by intrathecal CG 3509 (0.5 Mg) were attenuated when ritanserin was administered intrathecally 30 min before, but not when it was given at the same time as CG 3509 and neither behaviour was altered by intrathecal 5,7-DHT. This suggests that bulbospinal 5-HTergic neurones are not involved in the production of these TRH analogue-induced behaviours and that the 5-HT2 receptors which mediate these behaviours are not located in the spinal cord.

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“…or 8-OH-DPAT (5 mg kg -1 s.c.). Three cages (each 563820 cm) of three rats were observed in each 3-h experimental session, with each cage being observed for 5 min of every 15 min (Koshikawa et al 1985). FPT, evoked by 8-OH-DPAT or 5-HTP, was assessed for each 5-min period as follows: 0 = absent, 1 = present once, 2 = present several times, 3 = present frequently, 4 = present continuously (Dickinson and Curzon 1983) immediately after giving 5-, 8-OH-DPAT.…”

Section: -Htp-and 8-oh-dpat-induced Behaviours (Experiments 1-4)mentioning

confidence: 99%

Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning

et al. 2003

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Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats

Cited by 28 publications

References 24 publications

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

Involvement of 5‐HT₂ receptors in the behaviours produced by intrathecal administration of selected 5‐HT agonists and the TRH analogue (CG 3509) to rats

Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning

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Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats

Cited by 28 publications

References 24 publications

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

The Acute and Chronic Effects of MDMA (“Ecstasy”) on Cortical 5-HT2A Receptors in Rat and Human Brain

Involvement of 5‐HT2 receptors in the behaviours produced by intrathecal administration of selected 5‐HT agonists and the TRH analogue (CG 3509) to rats

Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning

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Involvement of 5‐HT₂ receptors in the behaviours produced by intrathecal administration of selected 5‐HT agonists and the TRH analogue (CG 3509) to rats