Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice

Kameyama, Tsutomu; Nagasaka, Mitsuaki; Yamada, Kiyofumi

doi:10.1016/0028-3908(85)90133-9

Cited by 27 publications

(15 citation statements)

References 32 publications

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“…The conditioned response on this test does not seem to depend on the anxiety state, because it is sensitive to antidepressant (24) but not to benzodiazepine treatment (30). Therefore, the change in the emotional state of mutant mice did not impair the conditioned response to stress.…”

Section: Discussionmentioning

confidence: 99%

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Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Maldonado

Smadja

Mazucchelli

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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Various transcription factors act as nuclear effectors of the cAMP-dependent signaling pathway. These are the products of three genes in the mouse, CREB, CRE modulator (CREM), and ATF-1. CREM proteins are thought to play important roles within the hypothalamic–pituitary axis and in the control of rhythmic functions in the pineal gland. We have generated CREM-mutant mice and investigated their response in a variety of behavioral tests. CREM-null mice show a drastic increase in locomotion. In contrast to normal mice, the CREM-deficient mice show equal locomotor activity during the circadian cycle. The anatomy of the hypothalamic suprachiasmatic nuclei, the center of the endogenous pacemaker, is normal in mutant mice. Remarkably, CREM mutant mice also elicit a different emotional state, revealed by a lower anxiety in two different behavioral models, but they preserve the conditioned reactiveness to stress. These results demonstrate the high degree of functional specificity of each cAMP-responsive transcription factor in behavioral control.

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Section: Discussionmentioning

confidence: 99%

“…The assay was performed as described (24). On the first day, the mouse was left in the test cage for 6 min and received electric footshocks (0, 1 Hz, 200 ms, 100 V) through an isolated stimulator (GL 260T, Société Ravia, France).…”

Section: Methodsmentioning

confidence: 99%

Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Maldonado

Smadja

Mazucchelli

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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“…The work of Kameyama et al (40) deserves special comments. Mice that received electric shocks, showed a marked suppression of motor activity when placed in the same cage 24 hours after the administration of shock.…”

Section: Discussionmentioning

confidence: 97%

“…The clear dose-dependent effect of amitriptyline on activity (see Fig 2), was expected because of the effect of this drug on spontaneous motor activity (40,41,42,43). A number of animals of the 30 mg/kg amitriptyline groups, two males and five females, did not move from where-they were positioned at the beginning of the test, i.e.…”

Section: Discussionmentioning

confidence: 98%

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Parra

Everss

Monleón

et al. 2002

Neuroscience Res Communica

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SUMMARYThe effects of acute administration of amitriptyline on memory consolidation in male and female CD1 mice were investigated. Three doses of this tricyclic antidepressant (7.5, 15 and 30 .mg/kg) were administered immediately after inhibitory avoidance training. Forty-five minutes after injection, subjects explored the elevated plus-maze for five minutes. Subjects were tested for avoidance twentyfour hours later. Amitriptyline impaired inhibitory avoidance consolidation at doses 7.5, 15 and 30 mg/kg in males, and at doses 7.5 and 30 mg/kg in females. In the elevated plus-maze, amitriptyline had no effect on anxiety (percentage of open arm entries) and induced a dose-dependent impairment of activity (number of closed arm entries). The observed sex differences were limited to subtle stronger effects of amitriptiline in males than in females on inhibitory avoidance. These results indicate that acute amitriptyline administration produces retrograde amnesia on inhibitory avoidance, which does not seem be mediated by anxiolytic effects.

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“…On the other hand, the conditioned fear stress model in mice examines psychological stress-induced motor suppression (12,13). It has been recognized that the conditioned fear stress model might be a stress model reflecting the emotional abnormality including depressive and/ or anxiety state (14,15). Furthermore, it has been reported that conditioned fear stress-induced motor suppression is attenuated by antidepressants as well as anxiolytics (15 -17).…”

Section: +)-4-[(ar)-a-((2smentioning

confidence: 99%

Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

et al. 2004

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Abstract. In the present study, we investigated the antidepressant-and anxiolytic-like effects, a non-peptidic selective d -opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the duration of immobility in the forced swimming test. Furthermore, in the elevated plus-maze test, SNC80 dose-dependently and significantly increased the time spent in the open arms of the plus-maze. These effects were completely antagonized by a selective d -opioid-receptor antagonist, naltrindole. In the conditioned fear stress test, which examines psychological stress-induced motor suppression, desipramine did not produce any significant effect on the conditioned suppression of locomotor activity. However, SNC80 completely attenuated the conditioned suppression of locomotor activity in the conditioned fear stress test. In conclusion, our results suggest that d -opioid receptors may play an important role in the regulation of emotional responses. Furthermore, it is possible that d -opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects.

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Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice

Cited by 27 publications

References 32 publications

Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

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